Peter W. Laird (@peterwlaird.bsky.social)
@peterwlaird
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DNA methylation & cancer epigenetics. Tweets are my own. I tend to stick to science.
Grand Rapids, MI, USA
Joined November 2012
Our paper on deep single-cell DNA methylation analysis is out in Nature Communications https://t.co/jpwk36NbR3. Super elegant work by Nathan Spix describing replication dynamics, X-inactivation, and cell lineage identification.
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Origins of DNA Methylation Alterations in Cancer: Peter W. Laird addressed this topic in a keynote lecture at the AACR Special Conference on DNA Methylation, Clonal Hematopoiesis, and Cancer. #AACRmethylation25 @peterwlaird
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Thrilled to share the results @Cancer_Cell of years of hard work to develop classifiers for all major TCGA cancer subtypes, enabling assessment of differential drug response among cancer subtypes in clinical trials.
cell.com
Ellrott et al. provide a means to assign patient samples from clinical trials and other cancer genome studies to published TCGA molecular subtypes. Applying machine learning to data from five...
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Online Now: DNA hypomethylation promotes UHRF1-and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin states https://t.co/xX336PoECe
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Origins of DNA Methylation Alterations in Cancer: Peter W. Laird will address this topic in a keynote lecture at the AACR Special Conference on DNA Methylation, Clonal Hematopoiesis, and Cancer (February 1-4, San Diego). https://t.co/2ea5ZLxKf1
#AACRmethylation25 @peterwlaird
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Congratulations to VAI's @DrRGJonesLab and @peterwlaird for being named to this year's @Clarivate Highly Cited Researchers list — a distinction that marks them as leaders in their fields. Read more: https://t.co/lDETcZQCOl
#HighlyCited2024 @ClarivateAG
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Congrats to our newest Genetics PhD, Dr. Felicia Ebot-Ojong! Here Felicia is with her advisor Dr. Zack Lewis @UgaChromatinLab Felicia will start a position at the Van Andel Institue @VAInstitute with Dr. Peter Laird @peterwlaird We are proud of you Dr. Ebot-Ojong!
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🎉Thrilled to share that my 1st first-author paper is now published on @ACSPublications Analytical Chemistry! 📚 After 5 years of hard work, dedication, and perseverance, this project has finally come to fruition. Feeling both incredibly happy and deeply touched. Thank you to
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Excited with to share our new deep single-cell whole genome bisulfite sequencing technique with @shenhui1986, along with some truly innovative DNA methylation analyses by lead author and talented MD/PhD student, Nathan Spix
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Check out our discussion with @ReizelTzachi on the causality of replicative epimutations in aging, cancer, & epigenetic clocks. 👆
The interplay between DNA methylation and cellular replication is complex. The recent review by @zhouwanding and myself in @TrendsGenetics delves into this intricacy. Feel free to take a look (now with a link that works):
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Excited to be part of this single-cell chromatin accessibility study in cancer in @ScienceMagazine. Congratulations to my collaborators @WJGreenleaf, @HowardYChang, and all our co-authors for this great work.
science.org
To identify cancer-associated gene regulatory changes, we generated single-cell chromatin accessibility landscapes across eight tumor types as part of The Cancer Genome Atlas. Tumor chromatin...
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🎉🥳✨ Excited to share my first preprint on @biorxivpreprint !! "Ultrasensitive amplification-free quantification of a methyl CpG-rich cancer biomarker by single-molecule kinetic fingerprinting", a new digital single-molecule method enabling amplification-free detection of DNA
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Yesterday we lost our wonderful friend Ilya @ISB_Shmulevich. Ilya was an amazingly creative scientist and incredibly generous colleague. He displayed extraordinary courage in his battle against AML, while remaining upbeat and living life to its fullest. We will miss him dearly.
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DNA methylation dynamics and dysregulation delineated by high-throughput profiling in the mouse Top cited paper from @CellGenomics - 20 citations https://t.co/jBZrvMiLia
@zhouwanding @ChildrensPhila @peterwlaird @shenhui1986 @VAInstitute
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Registration is also open for the VAI Epigenomics Workshop that will follow this year’s symposium. This 3-day, hands-on, problem-based experience will immerse PhD students in the latest epigenomics research and techniques. https://t.co/OgvPnnbaOc
vai.org
Join us for VAI Epigenomics Workshop at Van Andel Institute Stay informed about exciting upcoming events and activities.
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Congratulations to Dr. Peter Laird (@peterwlaird), Dr. Russell Jones (@DrRGJonesLab), & Dr. Peter Jones on being named to @Clarivate's 2023 Highly Cited Researchers list — a distinction marking them as leaders in their fields. Read more at https://t.co/zAb2bZI7Ys
#HighlyCited2023
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Evaluation of MethylationEPIC v2.0 now published in Epigenetics Communication! Another great collaboration led by the labs of @zhouwanding and @peterwlaird. Comment below if you have any questions about the BeadChip & its performance. https://t.co/Juj9uLC2nV
epicom.biomedcentral.com
Infinium Methylation BeadChips are widely used to profile DNA cytosine modifications in large cohort studies for reasons of cost-effectiveness, accurate quantification, and user-friendly data...
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