Chai Discovery
@chaidiscovery
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We’re excited to introduce Chai-2, a major breakthrough in molecular design. Chai-2 enables zero-shot antibody discovery in a 24-well plate, exceeding previous SOTA by >100x. Thread👇
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Hear directly from our founder Joshua Meier (@joshim5) and Mikael Dolsten on the exciting plans ahead. Welcome aboard, Mikael Dolsten! We're thrilled to have you join us.
🧬 Dr. Mikael Dolsten is joining the @ChaiDiscovery board!. In 15 years as @Pfizer's Chief Scientific Officer he:.⚛️ Progressed 150 molecules to clinical trials.💊 Delivered 36 approved medicines, from vaccines to cancer therapies
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Find out more about the evolution of Chai-1 to Chai-2, the 200x leap in antibody design success rates, and what this means for drug discovery. Great AI podcast with @JacobEffron of @Redpoint, hosting our co-founder @joshim5 of @chaidiscovery.
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Thank you @Nasdaq for the kind words and for lighting up Times Square! 💙. Excited to keep pushing the boundaries of molecular design with AI.
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RT @theinformation: .@grgyap, Partner at @MenloVentures, shares how generative AI is profoundly changing drug discovery:. "It offers you th….
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RT @MenloVentures: 🚀 Welcome to the portfolio, @chaidiscovery!.Their Chai-2 model achieved a 100x improvement in antibody design. This is h….
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RT @joshim5: Proud to announce @ChaiDiscovery has raised a $70M Series A from @MenloVentures & Anthology Fund (@AnthropicAI), @ThriveCapita….
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RT @OracleCloud: 🔬 Accelerating scientific breakthroughs with OCI. @chaidiscovery leveraged OCI to support the adv….
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🎉 Congratulations to @ZhuoranQ for winning the Chen Institute and @ScienceMagazine AI Prize, recognizing his groundbreaking AI research in biochemistry. We’re honored to have him on the @chaidiscovery team!.
Congratulations to the winners of the 2024 Chen Institute and @ScienceMagazine AI Prize! Winners share $50,000 in cash awards and their research essays will be published in Science. Learn more about grand prize winner @ZhuoranQ and finalists @Roobaert_Alizee and @neuronair here:
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Listen to today's @NoPriorsPod to hear why the @chaidiscovery team is bullish on biotech. Thank you to @saranormous for hosting @_jackdent and @joshim5.
🆕!! AI and atomic-level structure prediction are accelerating drug discovery — turning a slow, empirical search process into something closer to molecular engineering. @joshim5 @_jackdent co-founders @chaidiscovery chat their new bio foundation model, Chai-2. It enables
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RT @tbpn: We asked @joshim5 (Co-Founder @chaidiscovery) about the future of AI in biotechnology. "We have scientists working for years try….
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We’re grateful to many partners for making this possible: @OracleCloud for the massive compute that was required; @NVIDIAHealth for new GPU kernels and accelerating our sequence search; and @Sino_Biological and @AdaptyvBio for conducting many wet-lab experiments in the paper.
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We believe that these results mark a transition from empirical discovery to deterministic molecular engineering. ✨Reach out at if you’d like access to Chai-2.
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At the core of Chai-2’s success is its multimodal generative architecture, integrating all-atom structure prediction and generative modeling. This enables Chai-2 to create novel and epitope-specific binders. 🔬Whitepaper with more details:
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We prompt Chai-2 with 50 targets, test the designs in the lab, and observe a >15% hit rate. In just 2 weeks, we generate molecules, and synthesize + characterize them in the lab, without any iterative optimization or high-throughput lab screening.
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"OpenBind will deploy automated chemistry . to eventually generate more than 500,000 protein - ligand complex structures and affinity measurements over 5 years. This would represent a 20-fold increase over all public data produced in the last half-century.".
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We're excited to partner with the UK Government on OpenBind, an effort to create the largest open dataset of drug-protein interactions in history. More data → smarter AI models → better medicines.
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