Sequence diversity lost in early pregnancy | Nature @nature congrats to all collaborators on this landmark paper

New in Nature Metabolism: CNS GIPR and GLP-1R are both essential for weight loss response to a GIPR-Ab/GLP-1 peptide–antibody conjugate in mice—and this signaling happens through brain regions that reach outside the blood–brain barrier. This provides a new perspective on central

The most fun image & video creation tool in the world is here. Try it for free in the Grok App.

Delighted to see LLF580 (efimosfermin alfa) acquired by @GSK, an FGF21 biologic for MASH. Thanks to @BostonPharm for believing in this idea. Third NIBR-born spin-out to be acquired for approx $1 bn or more.

At the @MilkenInstitute Global Conference panel, we discussed how AI, genetics & protein engineering are transforming drug discovery. From our research targeting Lp(a) to uncovering potentially protective mutations in obesity, we’re entering a new era of precision and

Correction: MC4R deletion increases the BMI (not reduce).

Beautiful GWAS study of body mass index (BMI) from deCODE identifying a new risk gene FRS3 associated with BMI with supporting evidence from multiple ancestries. I particularly like the whole genome sequencing (WGS) analysis in the UK Biobank where the authors found a

https://t.co/hEGWTOLT0L

Fig. 2: World maps showing the allele frequency distribution of the four FRS3 missense variants identified in the study. | Nature Communications ⁦@NatureComms⁩ obesity and genetics. Ancestry specific variants Value of diverse ancestry

Interesting rare variant study from deCODE reporting a new risk gene for bipolar disorder: HECTD2, whose gene product appears to interact with lithium target GSK3β. This is the second interactor of GSK3β to be linked to bipolar disorder (first one is AKAP11). Thorgeirsson et

Analyses of rare genetic variants, especially in coding regions, provide unique insights into causal disease mechanisms — much more straightforward than common variant analyses🧬 In deCODE (Iceland) and UK Biobank, loss-of-function variants in HECTD2 and AKAP11 were associated

FRS3 as a BMI-associated gene, encoding an adaptor protein known to act downstream of BDNF and TrkB, which regulate appetite, food intake, and energy expenditure through unknown signaling pathways @NatureComms https://t.co/6qEu2lyBbN #obesity #genetics

Happy to share this work - great collaboration with @patsule, Andrea and many others! We report four missense variant in FRS3, each enriched in different ancestries, that associate with BMI. https://t.co/mzL2mwvGdz

@PalssonGunnar @decodegenetics @Skarkalinn @hakon_jon @stefansson_oa @hannespetur @patsule Research briefing summarizing the work

@PalssonGunnar @decodegenetics @Skarkalinn @hakon_jon @stefansson_oa @hannespetur @patsule https://t.co/UX1goX35xD - Sharing link for main paper.

Complete human recombination maps | ⁦@Nature⁩ ⁦@bvhalldorsson⁩ . A journey started 15 years ago.

So happy to see this published in NatComms! https://t.co/DGEdvJHfLg Rare variant assocs with birth wt identify 9 genes. Insights into links btwn earlygrowth and later metabolic health. Great collabs btwn teams Exe&Camb. Amazing resources of UKB & deCODE made it possible.

Cardiomyopathy —Genomic basis of dilated cardiomyopathy unravelled https://t.co/sgYy6UntTT https://t.co/g39RkCdz7J —Atrial cardiomyopathy of Athlete's heart https://t.co/wAWpfLMcN2

A novel role for PCSK9 inhibitors? At #AHA2024, we showed that early initiation of evolocumab was associated with fewer arterial aneurysms @TIMIStudyGroup @AndreZimerman

In FOURIER and FOURIER-OLE, earlier initiation of #evolocumab was associated with fewer AAA and non-AAA aneurysmal events, suggesting that PCSK9 inhibitors may prevent the formation and progression of arterial aneurysms. @PrakritiGaba #AHA24

Still, the genetic evidence to support NRK2 is not overwhelming