Pablo Alcón
@palconh
Followers
691
Following
2K
Media
23
Statuses
472
Scientist @MolBiolAU. From Extremadura, Spain. 🧬🔬
Aarhus, Denmark
Joined March 2023
Our latest work on FANCD2-FANCI (D2-I), a complex that helps resolve DNA crosslinks and replication stress, is out! https://t.co/bYoGGmbwkR We show D2-I acts as a sliding clamp on DNA, stalling at single-stranded gaps to identify and protect damage sites. @lapassmore @RuedaLab
19
53
154
13 years ago, the revolutionary genetic tool #CRISPR/Cas9 was published in Science, work that Emmanuelle Charpentier and Jennifer Doudna won a #NobelPrize for in 2020. On #WorldCRISPRDay, read the landmark paper that describes the discovery: https://t.co/RSVeBGgRiD
15
169
600
📢Please spread the word📢 Several postdoc positions (wet and computational) open in the lab to work on different research lines (see thread) We seek highly motivated candidates to join our team @CNIOStopCancer
https://t.co/FB0aq7gHfb E-mail CV and brief motivation statement
1
15
10
Our REPAIRome study finally out today in @ScienceMagazine !!! https://t.co/LOJHQa4Yqe
science.org
The analysis of DNA sequence outcomes provides molecular insights into double-strand break (DSB) repair mechanisms. Using parallel in-pool profiling of Cas9-induced insertions and deletions (indels)...
14
24
100
📣We're seeking a postdoc to join us @MRC-LMB to investigate neuroimmune interactomes in tumour & viral immunity. If you find fascinating & want to learn about #neuroscience & #immunology, tracing neurons, molecular biology & #flowcytometry, apply! 🧠🫁🔬 https://t.co/gvv5IjjS1Z
0
9
14
Today is the 45th anniversary of Our favorite television series Cosmos: A Personal Voyage by Carl Sagan. Comment below If you were inspired to study, teach or pursue a professional pathway in science, because of Sagan's COSMOS. ( You can Watch all the episodes here 👇 again)
Cosmos: A Personal Voyage is a thirteen-part, 1980–81 television series written by Carl Sagan, Ann Druyan, and Steven Soter, with Sagan as presenter. It was executive-produced by Adrian Malone, produced by David Kennard, Geoffrey Haines-Stiles, and Gregory Andorfer, and directed
18
80
315
Extremely happy to see the first paper of the lab out in @NatureSMB. We determined the cryo-EM structures of GluA4 (alone) and in complex with TARP2, trapping the receptor in different functional states.
New online! GluA4 AMPA receptor gating mechanisms and modulation by auxiliary proteins https://t.co/Dee998UI6H
4
8
51
"Extremadura, soledad llena de encinas sobre campos con veredas, ¿por qué se fueron los hombres de tu tierra?" Feliz Día de Extremadura. #Extremadura #DiadeExtremadura
0
18
66
🟩 Orgullosa ⬜️ Solidaria ⬛️ Inquebrantable Y recuerda: Aquí, nunca dejamos de renacer Feliz #DíaDeExtremadura
2
125
289
22nd August 2020 Dark clouds over The Flying Pig public house foretell the loss of community to greed. Justine and Matt Hatfield took over The Flying Pig in 1997 and during the twenty-four years of their tenure created and nurtured not just a homely local pub but also the
5
12
113
¿Quieres participar en el desarrollo de nuevos anticoagulantes sanguíneos cuya actividad sea reversible? Pues estás de suerte, porque @J_RipollRozada oferta un contrato predoctoral en @IBBTEC @unican @CSIC. Enviad las solicitudes a ripollj@unican.es Se agradece el RT.
0
14
15
Revolución en la medicina: una molécula producida por bacterias del intestino causa la aterosclerosis, culpable de millones de muertes. El descubrimiento, del @SanchoLab, se acaba de publicar en la revista @Nature 👇
elpais.com
El descubrimiento, gracias a un experimento con cientos de trabajadores del Banco Santander en Madrid, abre la puerta a nuevos tratamientos más allá de reducir el colesterol
3
49
89
If neuroimmunology and/or pain signalling are your things 💥, and you are looking for a PhD position 👨🎓👩🎓, check the post below! 👇 There is still time to apply for a PhD position in my lab and carry out your doctoral thesis on this exciting topic🔬🧪 More details below 👇
Want to do a PhD and are passionate about neuroimmunology? Curious about the crosstalk between mast cells and pain-sensing neurons? A position is now open in my lab—apply now! Details here👇 https://t.co/SKvNte6bAK Feel free to contact me for more info—and please spread the word
0
7
13
A tribute to Pedro Cuatrecasas, the Spaniard who (whilst working in the US) co-invented affinity chromatography.
Es difícil que una persona al azar no se haya beneficiado del descomunal trabajo del prácticamente desconocido científico Pedro Cuatrecasas. Participó en el desarrollo de unos 40 medicamentos, como el aciclovir, el sumatriptán y la atorvastatina
0
1
4
Es difícil que una persona al azar no se haya beneficiado del descomunal trabajo del prácticamente desconocido científico Pedro Cuatrecasas. Participó en el desarrollo de unos 40 medicamentos, como el aciclovir, el sumatriptán y la atorvastatina
elpais.com
El científico, fallecido a los 88 años en Estados Unidos, transformó la vida de millones de personas tras participar en el desarrollo de 40 nuevos medicamentos
4
39
125
Si no conseguistes un contrato FPU 2025, pero sigues interesado en realizar una tesis doctoral, contacta con nosotros para solicitar un contrato del Plan Propio de Investigación de la U. Sevilla. Unete a nosotros!! https://t.co/DszsiRHV27
0
4
4
📢 We’re hiring! Looking for a lab technician (FP level) with experience in cloning, protein expression & purification. 🧬 Join our structural & molecular biology lab @CIB_CSIC 🗓️ 2-year contract, starts Oct 2025 📩 Apply by July 31 👇
1
5
11
I'll soon be recruiting a postdoc fellow to join us @ MRC LMB to continue developing our programme to understand neuroimmune modulation 🧠🔬🧬🩸🫁 If you're interested in joining us check also @MSCActions, @wellcometrust & https://t.co/TkP61a8iPd & DM'me https://t.co/RxDcklWOsX
0
11
24
Want to do a PhD and are passionate about neuroimmunology? Curious about the crosstalk between mast cells and pain-sensing neurons? A position is now open in my lab—apply now! Details here👇 https://t.co/SKvNte6bAK Feel free to contact me for more info—and please spread the word
2
21
31
Researchers learned a function of enzyme MORC2, that helps organise DNA and turn off genes when not needed. Mutations in MORC2 cause Charcot-Marie-Tooth disease, a rare condition that weakens muscles. These findings could lead to new treatments. https://t.co/oDzT0FB7rd 🧵1/2
1
3
11
Happy and proud of this study where we propose that cross-reactivity between dietary and airborne antigens with molecular mimicry might play a role in explaining the concomitant appearance of in IBS and allergic rhinitis @BoeckxstaensLab
@TARGID_KULEUVEN
🆕🔥⬆️#AllergicRhinitis in #IBS patients & has a detrimental effect on #QoL‼️ 🎯Potential cross-reactivity between #Dietary & #Airborne antigens in patients with concomitant IBS & AR👏 👉 https://t.co/TMx11QqCzY
@BoeckxstaensLab @Javimmunopain @TARGID_KULEUVEN @ANMSociety @esnm_eu
2
7
20