Oscar Solis
@osolca
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🧠✨ Genetic Tools Atlas 3.0 is here! The GTA now has an additional 750 datasets, including 80+ mouse whole-brain light sheet microscopy images as well as the first macaque datasets. 🔗 https://t.co/nYJdW24A7w
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Happy to share our paper creating an atlas of the dendritic morphology of D1- and D2-MSNs and elucidating its organizational principle. Thanks to Chris Park, Ming Yan, Masood Akram, Hongwei Dong, Daniel Tward, and others. Funding from US BRAIN Initiative.
nature.com
Nature Neuroscience - The authors mapped the dendritic morphology of thousands of striatal D1-type and D2-type medium spiny neurons in healthy and Huntington’s disease mouse brains, revealing...
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Thrilled to share our latest work showing spatially segregated Ca2+ signals of NMDAR and mGluR5 have opposing effects to maintain synapse homeostasis, with implications towards rapid antidepressant action (1/3) https://t.co/eVx9VmKPWX
pnas.org
Major depressive disorder affects millions worldwide, yet current treatments require prolonged administration. In contrast, ketamine produces rapid...
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Cocaine-activated ion channels engineered to break the loop of addiction in rats
nature.com
Nature - Engineered ion channels reverse the effects of cocaine on activity in the brain’s lateral habenula to suppress drug seeking in rats.
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This was a fun piece to write for @TrendsinPharma “The ABCs of Psychedelics: A Preclinical Roadmap for Drug Discovery” with @john_mccorvy and @mantschjr
https://t.co/1KaExV2B2X
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I’m delighted to share that the first paper from my postdoctoral work has been published in @PharmacolRes! In this study, we describe how μ-opioid receptors (MOR) and CRF1 receptors (CRF1R) form heterotetramers with distinct G protein couplings https://t.co/eHFh0J6cv4
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Nature research paper: Cocaine chemogenetics blunts drug-seeking by synthetic physiology https://t.co/QqAwJmeylP
nature.com
Nature - Cocaine chemogenetics in rats is a selective approach for countering drug reinforcement by clamping dopamine release in the presence of cocaine.
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We used protein engineering to develop cocaine-gated ion channels. Our approach simplifies chemogenetic applications for cocaine addiction by having cocaine itself activate inhibitory and/or excitatory channels. Collaboration between @mikelides @BrainCaRMA
https://t.co/X4zUdhGUG2
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🎊So excited to share our new publication! We identified a novel circuit underlying threat processing and adaptive learning. Deeply grateful to @BBRFoundation and all the co-authors who made this possible! @IBG_CUBoulder @CUPsychandNeuro @NeurobioUMass
https://t.co/bSqPLIp5Sf
nature.com
Molecular Psychiatry - Interpeduncular GABAergic neuron function controls threat processing and innate defensive adaptive learning
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Our latest study identifies a specific cell type and receptor essential for psilocybin’s long-lasting neural and behavioral effects 🍄🔬🧠🐁 Led by Ling-Xiao Shao and @ItsClaraLiao Funded by @NIH @NIMHgov 📄Read in @Nature - https://t.co/teA2IhCpXi 1/12
nature.com
Nature - A pyramidal cell type and the 5-HT2A receptor in the medial frontal cortex have essential roles in psilocybin’s long-term drug action.
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ACNP Global Scholarship Applications are open! The ACNP 64th Annual Meeting is January 12-15, 2026, in Nassau, Bahamas. The deadline to apply is August 15, 2025, at 5:00pm Central. #ACNP2026 Click here for more info: https://t.co/U9QQxF1swT
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Hoy fue la presentación del nuevo investigador titular del laboratorio Tlaxcala en el Departamento de Fisiología de nuestra institución. Su llegada marca el inicio de una nueva etapa de crecimiento y excelencia científica @HiramTendilla @ConexionCinves
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I'm excited to share another piece from my PhD - and start of my postdoc! Based on our previous study refining heroin self-administration, we propose a choice procedure to identify individual differences in preference for heroin and social interaction. https://t.co/YBbPmIeji2
bpspubs.onlinelibrary.wiley.com
Background and Purpose In some individuals, opioid use leads to decreased interest in socially relevant rewards. Recent studies showed that after extended-access heroin self-administration, rats...
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GREAT NEWS! Our paper on dopamine signaling of valueless prediction errors is out in @ScienceAdvances! I found that striatal dopamine tracks cue-cue prediction errors in sensory preconditioning, which goes against model-free theories of dopamine function. https://t.co/Q91KwzURAC
science.org
Dopamine reflects prediction errors not only about reward but also about valueless stimuli, challenging many current theories.
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📢 Don't miss our recent review on the "Neurobiology of resilience to early life stress", published in @npp_journal! Great collaboration along with Alessandro Bortolami, Cathe Peña, and @EricJNestler. 👇👇
nature.com
Neuropsychopharmacology - Neurobiology of resilience to early life stress
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International Symposium on Addiction Research New Abstract Submission Deadline - July 25th, 2025 Registration is Free. 360 seats available In-Person, no limit Online. Venue: Institute of Neurobiology, Querétaro, México. 25/Aug/2025 - 27/Aug/2025 https://t.co/dM2xaG5gbx
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A brief guide to statistical analysis of grouped data in preclinical research
nature.com
Nature Metabolism - Clustering and nesting (C&N) arise in many preclinical studies, such as when animals are group-housed or share litters, or in cell culture. Ignoring C&N...
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Synergistic behavioral and neuroplastic effects of psilocybin-NMDAR modulator administration #psychedelics
pubmed.ncbi.nlm.nih.gov
The full therapeutic potential of serotonergic psychedelics (SP) in treating neuropsychiatric disorders, such as depression and schizophrenia, is limited by possible adverse effects, including...
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Thrilled to see this come to life and to have been part of the journey since the very beginning. Huge congratulations to Pablo and Gilles on building such a nice story!
nature.com
Nature Neuroscience - This study demonstrates that high alcohol concentrations during binge drinking activate a small GABAergic neuronal ensemble in the medial orbitofrontal cortex, which...
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Glia | Astrocytes Mediate Psychostimulant-Induced Alterations of Spike-Timing Dependent Synaptic Plasticity
onlinelibrary.wiley.com
Cocaine and amphetamine stimulates astrocytes and downregulates the GLT-1. The dysfunction in GLT-1 modify EPSP kinetics and modulate STDP, switching LTP to LTD in psychostimulant-treated mice....
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