Eric J. Nestler, MD, PhD
@EricJNestler
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Director @SinaiBrain. Research Dean & Nash Professor at @IcahnMountSinai studying the molecular basis of addiction & depression. Diversity drives excellence.
Joined July 2014
I am proud to share this new review on The Biology of Addiction that appeared today in @scisignal. It was fun to write the review all by myself and reflect on the tremendous progress achieved over the past three decades.
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It is with unspeakable sadness and shock that I reflect upon the unexpected passing yesterday of Ron Duman, a beloved husband and father, a leader in the field of psychiatric neuroscience, and a dear and close friend and colleague of mine for >3 decades.
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Mount Sinai's new BioMedical Laureates Program will add 20 Black or Latinx faculty to our basic and clinical science enterprise over the next five years. This will transform our campus and the impact and reach of our work. We could not be more excited about this new initiative.
.@IcahnMountSinai unveiled BioMedical Laureates at Mount Sinai, a program intended to increase #diversity among its basic and clinical research faculty and reinforce the school’s strong ethic of mentorship. Learn more:
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We are delighted to see the publication of the 6th Ed of Charney & Nestler's Neurobiology of Mental Illness by Oxford Press.
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Paul Greengard was a paradigm-shifting scientist who changed fundamentally the way we understand cell signaling. He was uniquely generous and was like a second father to so many of us. An end of an era. He will be missed.
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I am especially honored by this recognition and want to thank the many PhD students and postdoctoral fellows who have been part of my lab over the years and who performed the work for which I'm being recognized.
Thank you @SfNtweets and the Schaller-Nikolich Foundation for honoring the outstanding achievements that Dr. Nestler has made to the field of #neuroscience! . A HUGE CONGRATULATIONS @EricJNestler!✨🎉. Learn more👉
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Sorry to brag, but I'm so pleased to say that Mount Sinai's Departments of Neuroscience, Psychiatry, and Neurology are all in the top 10 by NIH funding in 2018. A great milestone for us.
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1/2 @IcahnMountSinai is ramping down basic research to slow the spread of COVID-19. Making this decision goes against every instinct in my body--I never thought I'd see such a disruption to our nation's research enterprise, but it's an important step for everyone's safety.
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We are incredibly proud to be among the first institutions to receive NIH's new Faculty Institutional Recruitment for Sustainable Transformation (FIRST) awards, the goal of which is to increase the diversity of our research faculty.
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I just completed my term as SfN president–the privilege of a lifetime. A tremendous thanks to our fabulous professional SfN staff who serve our members so well. And thanks to our >30,000 attendees. #SFN2017.
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Ron and I met in 1986 as postdocs. We joined the Yale faculty, founded the Laboratory of Molecular Psychiatry--the first in the country, and worked as partners in research for the next 13 years. We published 60 papers together and had enormous excitement and fun along the way.
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We are proud to announce the publication of a new study by @angelica_atb in @NeuroCellPress which characterizes a novel role for H3K27me1 as a "chromatin scar" in nucleus accumbens that contributes to long-lasting sequelae of chronic stress. @SinaiBrain .
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I am deeply honored by this recognition but must thank the many postdoctoral fellows and PhD and MD-PhD students in my lab over the years whose creativity and hard work made this possible.
.@SinaiBrain & @IcahnMountSinai congratulate @EricJNestler for his election to @theNASciences of the USA. This great honor recognizes Dr Nestler’s cutting-edge work on the molecular basis of drug addiction & depression & on advancing the field of psychiatry into the molecular era
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I want to draw your attention to a Neuroscience Forum workshop that I'll be moderating next week on September 23 focused on sex differences in neurological and psychiatric disorders based on transcriptomic data, with implications for therapeutics and policy. Please register!.
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I have long shown the slide below to make the point that it's hard to ascertain complex emotions in a rodent. This new study challenges my snarky slide but I stand by its major point!
Pushing the envelope for mouse behavioral obs: facial expressions reflect emotional state of malaise, fear, or sweetness. Groundbreaking proof of robustness by @NadineGogolla. Who are the faces for? Can a mouse fake a smile?
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1/3 Our nation's biomedical research enterprise faces crushing financial pressure from lost productivity caused by shutting down laboratories. I hope that Congress and the President will include robust support for NIH and its grantees in recovery bills now under consideration.
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The end of "manels." Mount Sinai is proud to commit to organizing and hosting panels and symposia that include women or members of groups underrepresented in science and medicine. And our leaders commit to only participating in diverse panels elsewhere. @SinaiBrain @MountSinaiNYC.
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Thank you all for acknowledging my obsessive relationship with my email. Answering emails so quickly is a highly potent anxiolytic. When I'm sitting in meetings and see those emails tick up (alarmingly and shockingly quickly some times) my stress levels rise! What a world. .
Which is why email is not a reliable way to contact me. It is a 3 person job and I require professional assistance to get to the bottom😅. But then there are people like @EricJNestler who have GOT to be receiving way more that reply in 30 s to every email.🤷🏻♀️.
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PhD training should never be toxic and it is shocking that so many programs still are. PhD students should work hard and many experiments don't work--particularly at the outset, which is often frustrating and dispiriting.
@ElliotMiles8 They absolutely do exist. Was very lucky to work in a lab shared byRon Duman and @EricJNestler in the basement of the CMHC building @YaleMed - there was an amazing camaraderie and joy for science in the lab and it made the struggles of graduate school much easier.
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We will sorely miss the SfN annual meeting this fall. In fact, submitting SfN abstracts has become such a "rite of spring" that my lab went ahead and prepared "shadow SfN abstracts" nonetheless, which can be found here:
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Please see this new publication by Arthur Godino, Marine Salery, and others now online in @Nature. We show opposite roles for D1 vs D2 dopamine receptor- expressing neurons in ventral hippocampus in controlling approach-avoidance behavior. @SinaiBrain.
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Please see this new review on Neurobiology of Resilience by @ScottRussoPhD and me which just appeared online in @NeuroCellPress.
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I am incredibly proud of @IsslerOrna and our collaborators for this new work using integrated human-mouse investigations to understand the molecular mechanisms of sex differences in depression. This exciting discovery has inspired my very first "tweetprint". Here we go…🤞🏼.
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Paul, thank you for all you did for me--professionally and personally. We love you.
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Please see our latest paper on transcriptional mechanisms of cocaine action in nucleus accumbens medium spiny neurons, focused on RXRalpha and its downstream effects on gene expression, in Neuron by Arthur Godino and others. @SinaiBrain .
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As scientists we must always be open to evaluate new empirical data. But the conclusions of this paper are counter-intuitive and contrary to everything we’ve seen over the years.
We're aware of the concerns raised regarding the publication of this paper We thank those who've contacted us about this issue & we're looking into it as a matter of priority. @NatureComms strongly believes in & supports equality and diversity in research.
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I am so honored to receive @ACNPorg's Barbara Fish Award. Dr. Fish was one of the founding members of the College, now close to 60 years ago. The ACNP played an instrumental role in my career development. @SinaiBrain.
ACNP is pleased to announce the 2021 Honorific Award Recipients for the following: Daniel H. Efron Research Award-@KafuiDzirasa, Joel Elkes Research Award-@Auerbach_Lab_CU, Eva King Killam Research Award-@ahmari_lab & Barbara Fish Memorial Award-@EricJNestler #ACNP2021
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Please see this article published today in @ScienceMagazine, which represents a spectacular collaboration between my lab and two close colleagues at @RockefellerUniv, Jeff Friedman and Alipashi Vaziri, and was performed by Bowen Tan, Caleb Browne, and Tobias Nöbauer. @SinaiBrain.
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This is a tremendous honor. I look forward to working with my many outstanding colleagues - faculty, trainees, and staff - to continue Mount Sinai's spectacular upward trajectory. An enormous thank you to Dennis Charney for his leadership over the past 20 years. @IcahnMountSinai.
A HUGE CONGRATULATIONS to Dr. @EricJNestler on being named Interim Dean @IcahnMountSinai! As we express great enthusiasm for Dr. Nestler becoming Dean & the exciting time ahead, please join us in thanking Dean Charney for his extraordinary service & commitment to @MountSinaiNYC.
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A huge thank you to Shelby White and Meredith Ross of the Leon Levy Foundation for naming @ScottRussoPhD as the inaugural Leon Levy Director of the Brain and Body Research Center at @IcahnMountSinai. Congratulations Scott! @SinaiBrain
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Thank you @Concordia for this tremendous honor. I am very appreciative of this recognition, and want to congratulate my fellow honorary awardees as well as all of your graduating students this fall for their accomplishments. @SinaiBrain.
#Concordia confers honorary doctorate to @EricJNestler for his contributions to #research, public #advocacy and training in the fields of #drug #addiction and #depression .Learn more➡️.#CUcelebrate #CUpride #CUHonDoc #CUalumni
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Join us tomorrow for "A Celebration of Ben Barres: The Life of a Transgender Neuroscientist," to be held in Mount Sinai's Davis Auditorium (1470 Madison Ave) on Monday October 7 at 5 pm. Sponsored by @SinaiBrain as part of our #DiverseBrains (Diversity in Neuroscience) series.
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A bittersweet lab party tonight to say thank you and farewell to 4 star lab members: @FreddysonJ who is en route to a faculty position at University of Florida, @angelica_atb en route to Harvard/MGH, @IsslerOrna en route to NYU, and @PhilippMews en route to Boston University.
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Getting back to the animal surgery room with several colleagues.
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The study integrates numerous experimental approaches to demonstrate neural and molecular substrates through which repeated exposure to cocaine or morphine corrupts an individual's responses to natural rewards.
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Happy International Day of Women and Girls in Science 2019. And thanks to the amazing women who have made my lab such a success over three decades.
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Please see this exciting publication by @PhilippMews and others which describes a novel "chromatin scar" induced by cocaine, lasting depletion of H2A.Z from nucleosomes, in nucleus accumbens medium spiny neurons that drives gene priming and drug relapse.
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Mount Sinai's @SinaiBrain is a proud sponsor of @BlackInNeuro.
🗣🗣🗣 It’s FINALLY here! . Check out the official #BlackInNeuroWeek schedule below. More details coming soon 🧠✊🏾
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We are thrilled to share the incredible news that two of @SinaiBrain's star faculty, Yasmin Hurd and Helen Mayberg, were elected to the National Academy of Sciences.
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A special moment at ACNP in Phoenix – running into so many former lab members, all thriving at their home institutions: Liz Heller, Orna Issler, Colleen McClung, Will Renthal, Cate Peña, Benoit Labonté, and Peter Hamilton. #ACNP2024
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I had such a fabulous time visiting @VanderbiltBrain and catching up with its director @LisaMonteggia. Also caught up with @TheErinCalipari. So proud that both are former postdocs in my lab. And hope to welcome future postdoc @veronikakondev. Vanderbilt neuroscience is thriving.
TODAY come see @EricJNestler at the Discovery Lecture Series! @VanderbiltBrain will be hosting a reception immediately after on the VBI terrace.
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I am deeply saddened by Bruce McEwen's passing. He was a uniquely generous and generative scientist and will be missed tremendously.
Devastated to report that my mentor & friend Bruce McEwen has passed away. He was the best of us: a fantastic scientist, super collaborator with encyclopedia-like knowledge of hormones & the brain.Special issue in FIN (2018) as an ode to Bruce & his work:
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I'm a very proud PI that two outstanding scientists in my lab, Cate Peña (@Cate_cholamine) and Deena Walker (@walkerdm79) both won ACNP poster awards at #ACNP2018. @SinaiBrain.
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It is bittersweet for us to bid farewell to Vanna Zachariou as she takes the helm as Chair of Pharmacology, Physiology, and Biophysics at BU. Vanna is a cherished colleague, collaborator, and friend and we look forward to much more work together in the coming years. @SinaiBrain
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Our program today was disrupted by a hateful Zoom bomb. It's a reminder of the importance and urgency of our work to overcome systemic racism and bias.
✨TODAY at 12pm! Register to hear the @Sci_Diversity’s Drs. @EKTBenn @ClarkNeuro @DrJamiliaSly & @tracymlayne along w/ host @EricJNestler as they attempt to answer this important question: “WHY IS SYSTEMIC RACISM BAD FOR SCIENCE?” .JOIN THE CONVERSATION➡️
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2/2 The challenge is for everyone to remain maximally productive during this period so that we can ramp back up on the other side. This WILL pass. We WILL get through it.
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I want to share an email that I sent yesterday to members of the FBI at Mount Sinai. That's the Friedman Brain Institute @SinaiBrain!.
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We are delighted to announce a special research symposium on Tuesday October 3, 2023 to celebrate 15 years of The Friedman Brain Institute at Mount Sinai and recognize our extraordinary achievements in basic, translational, and clinical neuroscience. @SinaiBrain @IcahnMountSinai
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We are very proud to launch this new program which was developed by our neuroscience postdoctoral community and will be managed by them. The program has our strongest, most enthusiastic support. @SinaiBrain @DiverseBrains.
⭐️SCHOLARSHIP OPPORTUNITY⭐.#FriedmanBrainInstitute's & #NashNeuroscience's NEW "Emerging Scholars Program" is dedicated to supporting advanced #GraduateStudents from underrepresented backgrounds interested in postdoctoral work in #neuroscience. APPLY NOW👉
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I just had the great honor of hosting Hilary Marusak, Ishmail Abdus-Saboor, and Talia Lerner as this year’s One Mind Rising Star Award winners at the 30th Music Festival for Brain Health.
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Mount Sinai is very proud of our own Ian Maze for winning a Presidential Early Career Award for Scientists and Engineers (PECASE). @SinaiBrain.
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First Christmas/Holiday party today for @SinaiBrain in three years. It was wonderful to get everyone together. With my great lab members.
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Each year @SinaiBrain sponsors The Art of the Brain Exhibition to showcase the intricate beauty of the nervous system and the ever-expanding tools used by neuroscientists to understand it in health and disease. Explore this virtual museum exhibit:.
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Ron Duman leaves behind a loving family, a legacy of scientific discovery and innovation, and so many of us in the field who will miss him terribly.
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We dedicated this evening's ACNP panel to the memory of our dear friend, Ron Duman, whose seminal work characterized the effects of stress and antidepressants on the brain.
LOOKING FORWARD to @ericjnestler & @SeneyMarianne chairing this evenings @acnp_org panel discussion on “Insight Into Sex Differences in Psychiatric Syndromes From Transcriptomic and Genomic Analyses”. NOT TO MISS! @IcahnMountSinai @PittTweet #ACNP2020
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Please join @ANeurogirl and me in hosting @TheRealDrDukes for two talks at Mount Sinai next week August 31: 11 am to discuss her research on nicotine and cannabinoids, and 4 pm to discuss @BlackInNeuro, its founding and current and future work. @SinaiBrain
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Mount Sinai received an award this evening for its efforts around diversity and inclusion from One Hundred Black Men (@ohbmny), a truly inspiring organization. A tremendous honor for Mount Sinai and an amazing evening of celebration and reflection. @SinaiBrain.
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Mount Sinai's Brain Fair is one of my favorite events of the year. This year we hosted several hundred school children from NYC to learn about and explore brain science. @SinaiBrain @dana_fdn.
Come take a tour of our brain at our #BrainFair and learn about brain cells, communication between neurons, language and stroke and more! #BrainAwarenessWeek @SinaiBrain @SinaiNeuro
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We are proud to share a paper by Sam Yeh and colleagues that just when online in @BiologicalPsyc1. We achieved a long-sought-after goal of mapping ∆FOSB binding genome-wide in nucleus accumbens (NAc) after cocaine administration by use of CUT&RUN-seq. @SinaiBrain.
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Mount Sinai announces recipients of nation's first gender equity grants. Congratulations to the winners who include @denisejcai and Sarah Stanley from @SinaiBrain and @taliaswartz from our MD-PhD program.
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The role of mentors and training directors is to provide the support and nurturance to help students through these obstacles and succeed with a robust body of work for their theses. In the end, despite the uncertainty inherent in discovery science, it SHOULD be fun.
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This is just one of many measures of our excellence, success, and leadership in neuroscience. Kudos to our faculty, postdocs, and students who make this possible.
PROUD to announce that @IcahnMountSinai's Department of Neuroscience (#NashNeuroscience) is ranked #2 in @NIH funding by #BlueRidge Institute for Medical Research (#BRIMR)! An INCREDIBLE milestone achieved thru hard work by the entire #FriedmanBrainInstitute community!
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Please tell your students and postdocs about an upcoming course, Molecular Basis of Resilience to Depression, offered by the Neuroscience School of Advanced Studies in Venice, September 21-28, 2019. @NeuroscienceSAS
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Mount Sinai is extremely proud of Yasmin Hurd (@HurdLab) and her impressive track record of scientific discoveries and mentorship of women in neuroscience. Thank you @SfNtweets for this important recognition.
Congratulations to Kristen M. Harris from @UTAustin and Yasmin L. Hurd (@HurdLab) from @SinaiBrain on winning the Mika Salpeter Lifetime Achievement! #SfNAwards20
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We are thrilled to showcase a new paper in @ScienceAdvances by @JDCalebBrowne and others focused on transcriptomic regulation induced in the brain’s reward circuitry by chronic heroin self-administration in mice.
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Very exciting news about the NeuroArts Blueprint and its goals to understand the influence of the arts on the brain and nervous system and mine this growing knowledge to maximize the use of arts to help individuals with a wide range of neurological and psychiatric disorders.
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I am delighted to see @TheErinCalipari receiving this year's Waletsky Award. Congratulations, Erin. I am so happy for you!.
Congrats to our very own @TheErinCalipari on the Jacob P. Waletzky Award from @SfNtweets recognizing her work on addiction! Find out more about the award here:
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It has been a lot of fun to have @ViditaVaidya be with us @SinaiBrain while on sabbatical as a Fulbright Fellow. Vidita gave a great talk last Friday on novel actions of serotonin and psychedelic drugs.
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At the @OneMindOrg Music Festival for Brain Health in Napa Valley. It’s great to see dear friends (Steve Hyman, Rob Malenka) and colleagues IRL (in real life) for a great cause.
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Huda has been an incredible and generous mentor and colleague to me and so many other members of our society. Congratulations to her on winning the Gruber Prize!.
What an inspiring talk by @Huda_Akil1 at #SfN2023! An incredible career and well deserved Gruber Prize 🏆. Congratulations Huda! Hope for engaging around mental health for all.
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Philipp Mews and I are thrilled to showcase our new paper in @scisignal on proteomic analyses of subcellular fractions of the mouse nucleus accumbens in response to cocaine administration, withdrawal, and relapse.
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I am so incredibly proud and pleased that @ian_maze2--who was a graduate student in my lab years ago--has been selected as an HHMI Investigator. Way to go Ian. @SinaiBrain.
The Howard Hughes Medical Institute (HHMI) has selected Ian Maze, PhD (@ian_maze2) as an HHMI Investigator. Watch the video to learn more about Dr. Maze's research and his advice to fellow researchers. @HHMINEWS #HHMIInvestigators #Investigators2021
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A lovely highlight of @ScottRussoPhD and his Brain & Body Research Center by @BBRFoundation. The work establishes the robust bidirectional connections between the brain and peripheral organs and their role in many diseases including stress-related disorders. @SinaiBrain
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Helen Mayberg and the new Center for Advanced Circuit Therapeutics promise revolutionary advances in brain therapeutics. @SinaiBrain
We are THRILLED to welcome Dr. Helen Mayberg as DIR. of Newly Established Center for Advanced Circuit Therapeutics @IcahnMountSinai! Dr. Mayberg is renowned for her study of brain circuits in #depression & for her pioneering #DeepBrainStimulation research.
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I am so proud and appreciative of being elected as an honorary member of Delta Omega Honorary Society in Public Health. Looking forward to today's MPH commencement ceremonies @IcahnMountSinai.
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Mount Sinai's 2024 Brain Fair! One of my favorite days of the year! @SinaiBrain @dana_fdn #BrainAwarenessWeek2024
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@IcahnMountSinai's neuroscience graduate program offers one of the most innovative curricula & broadest range of world-renowned research mentors across molecular, cellular, synaptic, circuit, systems, and behavioral neuroscience in the nation. #SfN23 @SinaiBrain @GradSchoolSinai
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The paper's findings, which require greater scrutiny, are potentially destructive to our very important efforts to increase the number of senior women faculty and women leaders at our nation’s academic institutions.
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So proud of @ANeurogirl for being one of the best poster winners at #Neuroepi23. Way to go Ashley! @themazelab @SinaiBrain @Fusion_Conf
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At the 2023 Tau Consortium Investigators Meeting in Boston, celebrating tonight the "Boston Tau Party." And BTW 2023 marks the 250th anniversary of the real deal in 1773. @tau_consortium
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Mount Sinai just launched a new app to track patients with COVID-19 infection in NYC with the goal of using AI to derive novel insight into risk and resilience factors and to promote good outcomes. @SinaiBrain @MountSinaiNYC
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I am thrilled to be welcoming prospective PhD students for graduate school interviews at @IcahnMountSinai this week! With world-class resources, a supportive community, & endless opportunities for growth, we can't wait to showcase our commitment to education & mentorship 🧑🏻🏫🔬
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So proud to have two members of my lab, Ashley Cunningham and Freddyson Martinez-Rivera, participate in SFN's Diversity Poster Session tonight 10/19 at 6:30-8:30 pm at McCormick Place Hall A. Sponsored in part by SFN's Neuroscience Scholars Program. @SinaiBrain @SfNtweets.
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Earlier today, four members of my lab, @FreddysonJ, @MinierAngelica , @angelica_atb, and @ellerojas_, visited Herricks High School on Long Island to speak at their research class, joining Herricks student Aidan Lin who works in my lab. I'm a 1972 grad of Herricks. Go Highlanders!
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We are so proud to share a review of @SinaiBrain's Art of the Brain Exhibition ( in @lancetneurology: Curated by Veronica Szarejko this Exhibition offers a spectacular window into the brain at the interface of art and science.
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As shocking and horrifying as was this disruption, we will not be deterred--to the contrary this will galvanize us. We will reschedule the event. We will persevere.
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Over 600 school children expected at today's @SinaiBrain's Brain Fair. Great to be back live.
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Nature just designated @MountSinaiNYC (including @IcahnMountSinai) as the leading healthcare institution in terms of AI publications globally, reflecting our enormous investment in AI and machine learning in redefining biomedical research and healthcare.
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Please see @IcahnMountSinai's latest supplement in Science, which focuses on the frontiers of brain research.
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It was bittersweet to preside over my 17th and last FBI Retreat as FBI Director, celebrating the spectacular growth and quality of @IcahnMountSinai's neuroscience community since our 1st retreat in 2009. And so pleased to hand the reins to @PaulKennyPhD as Interim Director.
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I had the great honor of delivering the inaugural George Heninger Lecture at Yale yesterday. It was a wonderful reunion. Heninger is the 4th from the left. We also honored George Aghajanian (2nd from left). Several generations of Yale Psychiatry.
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Heading to Washington DC for Neuroscience 2017. Join us for spectacular science and networking. Society for #Neuroscience (SfN)
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Congratulations to Mount Sinai's Paul Kenny on this great honor. @SinaiBrain @ACNPorg.
PROUD to announce @IcahnMountSinai’s Paul Kenny, PhD has been honored w/ @ACNPorg’s 2018 Daniel H Efron Research Award in recognition of his outstanding basic research contributions to neuropsychopharmacology. CONGRATULATIONS Dr. Kenny! #ACNP2018 @MountSinaiPsych @GradSchoolSinai
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Accepting @ViditaVaidya's challenge, here's my lab's version!
This is what we got upto on our labs whatsapp chat. Let's see your labs version. Hutment lab ala "Benjamin Button" style.
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Join us for a provocative and important discussion of why our nation’s MD-PhD programs have struggled to recruit women at a time when women admissions to MD only or to PhD only programs has excelled nationally. Why is training physician-scientists so different? @SinaiBrain.
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