Nicholas Mancuso
@nmancuso_
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Associate Professor @KECKSchool_USC @uscpphs @qcb_usc. Center for Genetic Epi. Genetics/Stats/ML. Husband and father. GA➡️CA. He/him. Views are mine.
Los Angeles, CA
Joined April 2015
RT @jmschreiber91: In the genomics community, we have focused pretty heavily on achieving state-of-the-art predictive performance. While u….
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RT @SashaGusevPosts: @slatestarcodex Thanks for the pushback, as well as for giving me the option to read Grok-ified version as a treat, th….
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RT @krichard1212: Fun fact, half of the behavioral genetics association members quit after their methods have been used to argue for racial….
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They're just n dimensional matrices, right?. *ducks*.
Tensors are instrumental in physics, machine learning and even biology. Einstein once begged a friend to help him understand them, fearing he was going mad. Joseph Howlett explains how they work:
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RT @HGGAdvances: 📣New from Lin et al!.📄Genetic Rare Disease Prevention and Control: Family-Based Screening and Reproductive Interventions i….
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What steps has SSGAC taken to verify what has been claimed?.
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RT @aguirre404: The second half of my PhD work is now on bioRxiv!. We show how data on expression quantitative trait loci (eQTL) relates to….
biorxiv.org
In human populations, most of the genetic variance in gene expression can be attributed to trans -acting expression quantitative trait loci (eQTLs) spread across the genome. However, in practice it...
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@hsu_steve Instead of the tedious gene editing, chromosome editing/transplant with potentially large effects has been done. From my simulation, on average selection from 24 donors for chromosome transplant (ignoring adverse pleiotropic effects for the moment) could raise IQ from 100 to 160
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RT @MariosGeorgakis: A neat example of how tissue pQTLs & eQTLs can complement the interpretation of GWAS data for complex traits. The stu….
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RT @krichard1212: @nmancuso_ Robert Plomin argues that variation in family environment has 0 influence on IQ. And somehow he still gets inv….
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RT @TanentzapfLab: The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is t….
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A lot of punk bands at that time had nailed the sound but The Adverts were the first to try to take lyrics somewhat seriously imo. I wouldn't call their lyrics super profound or deep but still lightyears ahead of most contemporary punk bands.
Released 48 years ago today,.Gary Gilmore's Eyes by the punk rock band The Adverts, featuring the fantastic B-side "Bored Teenagers.". The Adverts – Bored Teenagers (Old Grey Whistle Test, 1978). #punk #punks #punkrock #boredteenagers #theadverts #history #punkrockhistory #otd
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RT @PunkRockStory: Released 48 years ago today,.Gary Gilmore's Eyes by the punk rock band The Adverts, featuring the fantastic B-side "Bore….
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RT @AJHGNews: 📣Online NOW!.📄Estimation of demography and mutation rates from one million haploid genomes.🧑🤝🧑 @jgschraiber @DocEdge85 & co….
cell.com
Samples of millions of genomes provide substantial information about recent demography and mutation, but standard population-genetic methods make assumptions not met in these data. We introduce DR...
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RT @Andrei_Tarkhov: “garbage in, garbage out”: . last week, Nature Methods published an article ( comparing the dee….
nature.com
Nature Methods - The analysis presented in this Brief Communication shows that, despite their complexity, current deep learning models do not outperform linear baselines in predicting gene...
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RT @caina89: Very happy to share our new paper now on @medrxivpreprint: “Genetic risk effects act in sets”, a great effort led my PhD stude….
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The focus should be on helping/supporting students. Reorienting around IQ PGS is a punt and says, "wellll let's just select smarter babies instead", which is a complete fiction.
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Whats funny about comments like this, is that if they've exhausted their abilities for successful school- or student-based interventions, and their next idea is to focus on a genetic-based IQ PGS, then you've completely lost the point.
I suppose one could start by looking at value-added models to see what percent of variation of educational outcomes is due to schools. (Versus things like individual differences.). One could also look to see if there have ever been any large scale educational interventions and.
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