A million views on a post introducing our important new research. It's gratifying seeing the reach this has gotten from just my personal account. Our @herasight inbox is blowing up with interest from couples looking to screen. Very exciting! Thanks to everyone who engaged.

Our study shows that powerful genetic prediction of cognitive ability is not only possible but likely to be highly beneficial when applied in embryo selection, resulting in meaningful increases in intelligence as well as reduced psychological problems and disease risks.

Polygenic prediction accuracy is known to decrease with genetic distance from source data (here European). CogPGT followed this pattern, with correlations decreasing by up to 40% for African-American and East Asian samples, compared to only slight decreases for US Hispanics and

Some previous results suggested that genetic effects on IQ vary by family background. We found no evidence for this when testing for interactions with family conflict, income, and parental education, suggesting similar effects by family background.

Higher CogPGT score was associated with lower risk for cardiometabolic diseases, including type 2 diabetes and coronary artery disease. Associations were consistent within-family, implying selecting for higher CogPGT score would slightly reduce cardiometabolic disease risk.

We found that the average CogPGT score among those in an occupation was strongly correlated with the (CAMSIS) occupational status of that occupation, with medical practitioners and higher education teaching professionals having the highest average CogPGT score.

We also looked at within-family associations between CogPGT, psychological traits and life outcomes in the UKB. CogPGT was associated with increased education, income, occupational status, friend satisfaction, health, and emotional stability.

We analyzed off-target effects of selection for IQ by correlating CogPGT with other outcomes, including behavioral phenotypes in 9-10 year olds. We find almost* uniformly beneficial correlations, including reduced ADHD symptoms and autistic traits with higher CogPGT score. *only

In a held-out validation sample from the UK Biobank (UKB), CogPGT achieves a population correlation of 0.406 with measured fluid intelligence, implying a population correlation of 0.521 with latent general cognitive ability (g). Similar results were obtained in an independent

Interested in using CogPGT in your IVF journey? Sign up here: https://t.co/d35ZLqicfd. Check out the CogPGT validation whitepaper here for all the scientific details: https://t.co/oG2YEUOzJE.

Today we reveal CogPGT, the world’s most powerful genetic predictor of IQ. We achieve a correlation with IQ of 0.51 (0.45 within-family). Herasight customers can boost the expected IQ of their children by up to 9 points by selecting the embryo with the highest CogPGT score. 🧵

Herasight have set a new standard in genetic prediction of Type 1 diabetes. T1D straddles the boundary between PGT-M (for single gene disorders) and PGT-P (for polygenic). There's an outsized contribution from risk alleles in the HLA region, so in families with a parent that

1/ We’re launching the world’s best Type 1 Diabetes predictor. It captures risk in key immune system genes and across millions of other genetic signals. Couples can now greatly reduce the risk of passing on this disease to their children. 🧵

In a way the more oligogenic architecture of an early-onset disease like T1D makes it more amenable to genetic prediction and embryo screening, assuming its HLA component is properly modeled. And that was done expertly here. Take a look!

[1] https://t.co/Fo4oC5nUFP [2] https://t.co/XBQnGmPIIm [3]

I don’t think the EAS PRS performances shown in Figure 5 yet justify that statement, which seems to suggest that the best available EAS PRS models now meet or exceed the best available EUR ones. Since these PRSmix+ EAS PRSs were trained and tuned on only 363k + 80k Taiwanese TPMI

Our in-house philosopher and bioethicist Dr. Anomaly just launched our comphrehensive ethics paper. IQ validation paper will follow very soon.

Meeting of ages. Osaka, 1960

1/ Today we launch an ambitious paper on the ethics of embryo screening. While the technology is new, our hopes and fears about our future children are as old as the Greek myths, including stories about Hera, goddess of fertility and the namesake of our company @herasight

The mean is not a sufficient statistic for the distribution. Scientific innovation comes from the far right tail. If you don’t admit the best foreign students, you get vastly fewer students in the far right tail.