Really proud to share the part of my postdoctoral work from @kaelin_lab that came out in @CD_AACR online first. See below for the key findings of our study.

RT @YUVSTRONG12: Thank you boys for your support , good luck at @HomeOfCricket.

RT @paulosiqamaral: @TumorBoardTues @brian_rini @IntegrityCE @DrRanaMcKay @montypal @katy_beckermann @JVentoMD @mzugman @DrChoueiri @tompow….

RT @albiemorkel: Thank you Temba and the rest!

RT @DanaFarber: In 2023, the @FDA approved belzutifan for certain kidney cancers –– thanks to years of work led by Nobel Prize recipient Wi….

RT @RKSayyid: #ASCO25 Excellent summary slide of trials of HIF-2α inhibitor therapy in refractory RCC. 📷@TiansterZhang.@urotoday https://t.….

RT @DhananjayHuilg1: I have a baby lab! We have some exciting questions on developmental neuroscience. Please apply if interested in joinin….

RT @nataliagandur: 🌟Insightful, data-rich, and clinically grounded presentation by @crisuarez08 at #IKCSEU25 @KidneyCancer @OncoAlert. 🟠 Be….

RT @kaelin_lab: We had a great time celebrating the group's many accomplishments!

RT @kaelin_lab: We report that Cyclin D1 is an important direct target of HIF2 that drives the proliferation of ccRCC. Our findings further….

RT @DanaFarber_GU: New study just out from @kaelin_lab in @CD_AACR elucidating more about the dependence of #kidneycancer tumor cells on H….

Importantly, I am very grateful for the support of @HopeFunds1 and @df_hcc Kidney Cancer SPORE to provide critical funding for my research.

6) Our findings further support the notion of combining HIF2 and CDK4/6 inhibitors to attain deeper and more frequent tumor regressions in kidney cancer.

5) The antitumor effects of HIF2 inhibitors appears to involve both cell-intrinsic effects through Cyclin D1 and cell-extrinsic effects through VEGF.

4) Surprisingly in HIF2 dependent ccRCCs, Cyclin D1 has kinase dependent (RB-family inhibition) and kinase independent activities.

3) ChIP-Seq @CFCE_DanaFarber and Pro-Seq @AdelmanLab confirmed that CCND1 is a direct transcriptional target of HIF2.

2) Our studies illustrate the power of CRISPR activation to probe drug mechanism of action, especially when the drug target (HIF2) is directly linked to transcription @broadinstitute and John Doench.

1) Sustaining the expression of the HIF2 target gene CCND1, encoding Cyclin D1, promoted HIF2-independence/belzutifan resistance.

RT @biomiko: I am excited to announce the launch of the Slabicki Lab at the Krantz Family Center for Cancer Research within the Mass Genera….

RT @kaelin_lab: We report a new role for HIF in the regulation of endogenous retroviruses! It was a big collaborative effort to explore the….