Requirements for establishment and epigenetic stability of mammalian heterochromatin https://t.co/kqyoS189Fv

Online now: Protocol for reconstituting enzymatic activities for ultra-large histone methyltransferases NSD1 and SETD2 using a baculovirus expression system https://t.co/e78FfrkaOE #protocol #starprotocols #cellpress

Paraspeckle protein NONO regulates active chromatin by allosterically stimulating NSD1

Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬　@shiori_iida @MasaAShimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗 https://t.co/2iISQjxjgh (1/3)

The epitranscriptome formed by the growing number of modifications occurring within mRNA transcripts.

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

I’m grateful to receive my NIH NIGMS-MIRA R35 award for the next 5 years for $275k direct cost a year. I genuinely appreciate my PO and NIGMS staff who worked tirelessly to make this happen, especially under a very challenging time for the biomedical research community. More to

Through tirelessly efforts, our graduate student @cheni_hsu published a manuscript in @STARProtocols to reconstitute enzymatic activities for ultra-large (>300kDa) histone methyltransferases NSD1 and SETD2. To our best knowledge, this is the first time their full-length forms

I'm suing the Trump administration over its unconstitutional and dangerous dismantling of @HHSGov.   Firing scientists, silencing doctors, and shuttering programs that help firefighters breathe and children thrive don't make America healthy.   It puts lives at risk.

So happy our paper on TFE3 fusion oncoprotein condensates in translocation RCC is online at Cell Reports! Great collaboration from @EnedaToska, @VitoRebecca1, Marston Linehan and @jihk99 labs. Proud of the work of our trainees Choon, Jane, Bujamin et al

Singapore created the world's most efficient healthcare system from scratch in one generation. They spend $4,000 per person on healthcare. We spend $15,000. Their secret? The exact opposite of what American "experts" recommend: 🧵

Hope this will arouse some consciousness across the street 😓

March for science @ DC

Our most recent Nature Cell Biology paper describes an innovative Perturbation-response Score (PS) method to decode heterogeneous responses of cells to perturbations at single-cell level. Particularly helpful for analyzing Perturb-seq data.

Congratulations to MCB student Zach Baker, first author on this article published in Nature Biotechnology! Read more about the research here.

First research paper as a PI. Paper is about HDAC3 and neurodevelopmental diseases.

The indiscriminate and ill-conceived slashing of indirects by the @NIH yesterday must be amended if want to restore America’s leadership role biomedical research. 15% simply isn’t enough for institutions to provide the basic infrastructure needed to run a successful lab. I say

I'm thrilled to share my lab's first manuscript identifying that paraspeckle protein NONO regulates active chromatin through allosteric activation of NSD1 on BioRxiv: https://t.co/ft5SOLZJ11 As a baby PI who started in a literally empty building, we weren't able to do biochem

Structural insights into the cooperative nucleosome recognition and chromatin opening by FOXA1 and GATA4 https://t.co/psZ7bQZFgL

Online Now: A CPF-like phosphatase module links transcription termination to chromatin silencing https://t.co/fzqxFaEsW5