Antonella Dost
@nella_dost
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Postdoc @TheCleversLab @_Hubrecht | RESPIRE4 fellow @EuroRespSoc | primary human alveolar #organoids and COPD modeling
Utrecht, The Netherlands
Joined September 2020
Pre-print alert! A primary human alveolar #organoid model that allows for 1) long-term expansion of progenitors; 2) AT2 maturation; 3) AT1 differentiation in defined media. Regenerating AT2s and AT1s show opposite responses to IFN-gamma! @TheCleversLab
biorxiv.org
Chronic obstructive pulmonary disease is characterized by inflammation and emphysema, leading to progressive alveolar destruction. Currently, no therapies effectively regenerate the alveolar epithe...
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The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid
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Having a great time at the #ERSCongress in Vienna. Lots of great networking with my fellow @EarlyCareerERS members @carola_voss @TheCleversLab
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What a great opportunity to participate in #LSC2024 and meet other RESPIRE4-MSCA fellows!🤗 I cannot feel more grateful for being part of the amazing and inspiring community of @EuroRespSoc! Looking forward to witnessing our contributions to the respiratory field 🫁🙌🏻
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A #RESPIRE4 Fellow meetup at the @EuroRespSoc #LSC2024 was convened in #Estoril 🇵🇹 today by ERS Fellowships & Awards Director @sejalsaglani (6th, from left) featuring @m_konigshoff (1st) & @RoryMorty (9th), who led a workshop on grant proposal writing. @EarlyCareerERS @MSCActions
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My final paper at @BCHStemCell @harvardmed @Carlakimlab merges cancer, inflammation and cell plasticity - we identified an injury/plastic state as essential for lung repair that is co-opted by early-stage LUAD! Exciting to see similar findings from @humam_kadara et al. in Nature
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Exciting news! As Guest Editor for @jovejournal, I'm organizing a methods video collection on “Studying Lung Cancer Using 3D In Vitro Models“. Interested in contributing? Submit your abstract now!" #lungcancer #3Dinvitromodels #organoids
https://t.co/Nu6mvylErx
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Rare cell type in the spotlight: Transcriptomic profile comparison reveals ionocyte core signature across multiple mammalian organs. Read it here in @SciReports by Carla Pou Casellas and @Cayetanopm: https://t.co/apvnavoT4I
#ionocytes #transcriptomics
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We are delighted to announce that our review on macrophages in lung cancer has been published in @eLife. It was a pleasure to work on this with @katarinabal and @HansClevers. @TheCleversLab @_Hubrecht #organoids
elifesciences.org
As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor...
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Fantastic EMBO Organoid conference #EESOrgan, thank you to the organizers for such a smooth event with (almost) no technical issues and plenty of networking opportunities
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Out today in the new issue @CellStemCell: Our Resource exploring early-stage lung cancer Thank you for the preview Jihan Osborne, PhD, and John Minna, MD. @aaronlavelmoye @Kottond
#lungcancer #lungbiology #stemcell #singlecell #cancer Free access link: https://t.co/siU4aACzgb
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Great collaborative effort from the Carla Kim lab, @Kottond lab, Yanagawa and Dubinett labs, combining organoid models, mouse models, and human patient data to study early stage lung cancer. Thanks to my co-first author @aaronlavelmoye and @CellStemCell
https://t.co/gqOmnX72LT
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Out now @CellStemCell! Using 3 systems, patient samples, and @10xGenomics scRNASeq we found that early-stage lung cancer cells have reduced lineage identity. Thanks to Kim lab, co-first author Nella, @Kottond and Jane Yanagawa @DamonRunyon @amays_bwfund
https://t.co/9rcDVHdLsD
cell.com
Early-stage lung cancer is poorly understood. Dost, Moye et al. introduce new organoid systems to model lung cancer. KRAS-expressing alveolar progenitor cells had reduced expression of lineage genes...
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