The Clevers Lab
@TheCleversLab
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Hubrecht Institute, Utrecht, The Netherlands
Joined September 2019
Do you want to learn how to make mouse thymus organoids?. Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue. Read it here: #Thymus #Organoids #STARProtocol #TEC.
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Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025. #ThymUS2025 #Organoids #Thymus
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Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development:
the-scientist.com
An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration.
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📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here:
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Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization.
pnas.org
Nuclear receptors (NRs) are widely expressed transcription factors that bind small, lipophilic compounds and regulate diverse biological processes....
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Watch back the 2024 EMBL Kafatos Lecture where @HansClevers presented about the application of organoids in disease modeling at the @_knaw Amsterdam. #embl #knaw #organoids
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RT @HansClevers: Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell….
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Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.
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The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid
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Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten .
star-protocols.cell.com
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all...
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RT @JensPuschhof: Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Rando….
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RT @HansClevers: British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet. ) https:….
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RT @_Hubrecht: How do stem cells form enteroendocrine cells of the gut? @TheCleversLab, @prinsesmaximac and @MaastrichtU used human gut org….
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The clevers lab is at the EMBL organoid symposium. Come see our posters today and tomorrow. Todays posters are: 75, 147, 169 . Tomorrows poster are: 52, 64, 162, 252, 254
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RT @VHIO: 📣 New VHIO – @CaixaResearch Scientific Seminars @FundlaCaixa❗️. 👨🔬 @Cayetanopm, @TheCleversLab @_Hubrecht.🔹 Using organoids to d….
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Rare cell type in the spotlight: Transcriptomic profile comparison reveals ionocyte core signature across multiple mammalian organs. Read it here in @SciReports by Carla Pou Casellas and @Cayetanopm: . #ionocytes #transcriptomics.
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Read more about what all happened "behind the paper" by @HendriksDelilah and @BArtegiani .
communities.springernature.com
The establishment of novel human 3D organoid models of non-alcoholic fatty liver disease facilitates drug testing, discovery of therapeutic targets, and research into the biology of the disease.
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When liver organoids turn fat; disease modelling, drug screening, CRISPR screening in #FatTracer and more. New paper from the lab now out in @NatureBiotech: #liver #organoids.
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Macrophages are an abundant immune infiltrate in lung cancer. We reviewed the use of 3D models for studying macrophage-epithelium interactions in this context. Now online @eLife by @katarinabal, @HansClevers and @nella_dost. #organoids #NSCLC #macrophage .
elifesciences.org
As macrophages are involved in various aspects of non-small cell lung cancer development and progression it is crucial to develop appropriate 3D co-culture platforms for modeling immune cell-tumor...
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