The Clevers Lab
@TheCleversLab
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Hubrecht Institute, Utrecht, The Netherlands
Joined September 2019
4/4 This work was a true team effort between @_amolf, @ihb_research, and the @_Hubrecht — led by @DanielKruegerDK and Kasper Spoelstra. Huge thanks to all collaborators for making it possible.
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3/4 This reveals a safeguard mechanism: epithelial cells constantly test each other’s mechanical strength. Too little (or too much) force destabilizes the barrier, linking extrusion to diseases like tufting enteropathy. Gut renewal is an active, force-regulated process.
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2/4 New in Science: Using live imaging, CRISPR myosin reporters, organoid villus substrates & optogenetics, we found that myosin-driven tissue tension—not compression—controls extrusion. Cells with reduced contractility are preferentially removed.
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1/4 Gut renewal is not passive “crowd control.” Instead of being pushed out by crowding or dying from apoptosis, cells compete in a mechanical tug-of-war. Weaker cells are eliminated—reframing intestinal homeostasis as a force-regulated process.
science.org
Cell extrusion is essential for homeostatic self-renewal of the intestinal epithelium. Extrusion is thought to be triggered by crowding-induced compression of cells at the intestinal villus tip. In...
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Do you want to learn how to make mouse thymus organoids? Our lab recently published a STAR Protocol on generating thymic epithelial organoids from adult mouse thymus tissue. Read it here: https://t.co/6cx5mM1C2E
#Thymus #Organoids #STARProtocol #TEC
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Our PhD student Sam presented our work on thymus organoids at this year’s Global Thymus Network meeting, ThymUS 2025. #ThymUS2025 #Organoids #Thymus
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Check out new @TheScientistLLC article highlighting our postdoc @AmandaARolf ’s work on a novel pancreatic organoid model that includes all three key cell types, offering new insights into pancreatic development:
the-scientist.com
An innovative organoid model mirrors the pancreas' complexity, generating all three key cell types to explore development and possible regeneration.
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📢New human fetal pancreatic organoid model generates all three key cell types of the pancreas. New paper in @CellCellPress by @AmandaARolf , @HansClevers and collaborators. See the article here: https://t.co/xcuc8drybh
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Recent work from our lab explored the role of multiple nuclear receptors in the human small #intestine. Using #organoids and small molecules, we activated and then studied one nuclear receptor at the time through transcriptome characterization. https://t.co/DtD0iWurgL
pnas.org
Nuclear receptors (NRs) are widely expressed transcription factors that bind small, lipophilic compounds and regulate diverse biological processes....
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Watch back the 2024 EMBL Kafatos Lecture where @HansClevers presented about the application of organoids in disease modeling at the @_knaw Amsterdam. #embl #knaw #organoids
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Exciting study! Organoid models reveal a novel role for human tuft cells in gut regeneration upon damage. Video: Tuft cell division is triggered by IL-4, visualized in human gut AVIL-Clover reporter organoids (Credit: Daniel Krueger) https://t.co/gXhem2rw0B
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Our postdoc @TheodoreGrenier visiting the @ENSLyon to talk about his research on #IBD and #organoids.
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One bacterial protein as a complement to #Matrigel/#BME: The #integrin -binding domain of the Yersinia bacterial protein Invasin, coated as a single protein, maintains a defined long-term culture of various epithelial cells as “2D #organoid sheets”. https://t.co/yeT3ieLmhf
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The Clevers lab is represented at the #ERSCongress in Vienna, with @nella_dost presenting her primary human alveolar lung organoid model @EuroRespSoc #organoid
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Do you want to genetically engineer your organoids rapidly and accurately? Check out our recently published STAR Protocol about implementing Base and Prime Editors in organoids! A protocol developed by @CelottiMartina and @geurts_maarten
https://t.co/dI1J8W9Vgr
star-protocols.cell.com
STAR Protocols is an open access, peer-reviewed journal from Cell Press. We offer structured, transparent, accessible, and repeatable step-by-step experimental and computational protocols from all...
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Another great collaboration with @Axel_R_Huber, @Cayetanopm, @JoskeUbels, @HansClevers, @BoxtelLab and many others. Random forest trained with #organoid #colibactin mutations => identification of pks-linked mutations in every 8th #colorectal tumor genome! https://t.co/HUbf9A3NCf.
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British science giants, laid to rest in the north aisle of the nave of Westminster Abbey (also includes my feet...)
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How do stem cells form enteroendocrine cells of the gut? @TheCleversLab, @prinsesmaximac and @MaastrichtU used human gut organoids to answer that question and identified ZNF800 as a key regulator. The results were published in Science today! Read more: https://t.co/Al4e6Uf85H
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The clevers lab is at the EMBL organoid symposium. Come see our posters today and tomorrow. Todays posters are: 75, 147, 169 Tomorrows poster are: 52, 64, 162, 252, 254
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📣 New VHIO – @CaixaResearch Scientific Seminars @FundlaCaixa❗️ 👨🔬 @Cayetanopm, @TheCleversLab @_Hubrecht 🔹 Using organoids to dissect the role of mutagenic bacteria in colorectal cancer 🗓 Friday, 28th April, 12:00pm 👨🔬 Host: @PaoloNuciforo ➕ https://t.co/R3vzd33N9P
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