Maria Konovalenko
@mkonovalenko
Followers
7K
Following
993
Media
145
Statuses
2K
Ops and Strategy at SonoThera, PhD in Biology of aging
San Francisco
Joined May 2009
Forget that “soup” analogy.
The protein concentration in the cytoplasm is so high that the average protein has a water hydration shell of only ≈ 10 water molecules separating it from the adjacent protein hydration shell.
0
0
2
100%. And give the family members the right to work right away and not after many painful years of changing visa status to something that grants the right to be employed.
We should be giving FREE “Golden Science Visas” to every smart AI researcher, biologists, mathematicians, materials scientists, physicists, and all other top scientists. And their families. Even if they don’t apply. We need the best and brightest in USA.
0
0
7
🧵5 Top Free Alternatives to BioRender for Scientific Illustrations! These five websites offer free scientific illustrations for biologists. Great for presentations, research papers and other research communication needs. Save and share the post!
20
608
2K
Former NCI chief and serial biotech entrepreneur raise $70 million to start companies that fail fast https://t.co/dopu2yPCh8 via @statnews Read about what Ned and Ned are doing at Jupiter 🚀
statnews.com
.@nes047 and @NathanielEDavid formed Jupiter Bioventures to quickly test out, and if necessary discard, ideas in biotech.
2
0
10
Jupiter Bioventures raises $70M fund for 'super-early' science - https://t.co/VLhkHIlyfn Very proud of my wonderful husband! Go Neds!
endpoints.news
They've got $70 million, two guys named Ned, and plans to go after early-stage science where other venture capital firms
2
1
11
Interesting how the session on Increasing Healthspan at BIO revolves around gene therapy manufacturing and other issues. Our approach can solve most if not all of them. Makes me feel very good about what we’re doing at SonoThera. #BIO2024 #longevity #healthspan #genetherapy
1
0
10
1/10: We are pleased to announce that our manuscript on the nature of epigenetic aging from a single-cell perspective is now published in Nature Aging:
nature.com
Nature Aging - At single-cell resolution, Tarkhov et al. delineate stochastic and co-regulated components of epigenetic aging, revealing a simultaneous loss of regulation at the epigenetic and...
7
26
101
This is pretty amazing: a single hominoid-specific genetic change leads to loss of the tail. What an incredible phenotype!
How did we lose our tail? A simple question.. but it wasn't really asked before! We discovered a plausible scenario for the genetic mechanism that led to tail loss. Amazing that such a big change may have been caused by such a small genetic event. https://t.co/0ZR8aH23PJ
@BoXia7
6
167
838
Is the best yet to come for cell therapy? I pulled together 45 companies in the space and charted the preclinical and clinical assets of each, segmented by cell source and modality Exhibit 1: Cell Therapy Landscape Some thoughts: The above is just a snapshot - an attempt to
16
63
329
We read papers on amyloid beta and alpha synuclein acting like prions in grad school. Now this is the first confirmation in humans. Scientists document first-ever transmitted Alzheimer’s cases, tied to no-longer-used medical procedure https://t.co/m1vi0ifN2r via @statnews
statnews.com
Scientists document the first-ever transmitted Alzheimer’s cases, tied to a no-longer-used medical procedure.
0
1
17
1/n: There are some academic papers that are so brilliantly and so accessibly written and so universal in scope that they transcend disciplines and stand as timeless testaments to both great thinking and great writing. Here's a short personal selection:
98
1K
8K
We would love to do this! Any SWEs interested in biology x AI research, please reach out
Arc should create a OpenAI residency type program where they take in software engineers and let them rotate between labs. SWEs get to work on problems in biology + lab productivity almost certainly increases. Eventually creates an incredible hacker culture in the institute!
19
23
514
i think cute
Golden mole that swims through sand rediscovered after 86 years
0
1
3
My only question: "Were there tiny seat belts that needed to be fastened when the mice went to and from Earth's orbit?" https://t.co/cTkbW5ae75
fiercebiotech.com
Chia Soo, M.D., will never forget the day the mice came back to Earth. | Astronauts in space lose bone at a rate of about 1% per month on average—twelve times the rate of people on Earth. Researchers...
0
0
3
Congratulations to Vera Gorbunova, Andrei Seluanov, Vadim Gladyshev and the team! Very very cool to see the "naked mole-fied" mouse living longer and healthier. And that's just one gene that was "borrowed" from the naked mole rat. I bet there are others.
Terrific study @nature showing that a naked mole-rat gene increases lifespan in mice. Mice overexpressing naked mole-rat Has2 have increased hyaluronan levels, lower cancer incidence, attenuated inflammation and a modest (4-12%) lifespan increase. https://t.co/TydOX2RmXB
0
1
20
This might sound strange in 2023, but ummm ... Y chromosome has literally just been sequenced in its entirety. What's 🤯 is that ~40% of men lose their Y chromosome from some of their blood cells by age 70. https://t.co/Tn0VNX06z1 via @statnews
statnews.com
"This is going to open up the capacity to figure out what the functional and medical consequences of the Y chromosome is.”
0
3
12
1/ 🤰What can we learn about pregnancy form 45 million lab tests? We present a dynamic atlas of pregnancy and postpartum based on measurements from over half a million pregnancies at a one-week resolution. @biorxivpreprint @AlonBar10
15
284
1K
Today we report in @ScienceMagazine a one-time base editing treatment for Spinal Muscular Atrophy (SMA), the leading genetic cause of infant mortality worldwide, affecting ~1 in 10,000 births. https://t.co/oLp8VN0Iiw PDF: https://t.co/JoKm9BxW89 1/17
30
459
2K
Imo this is beautiful. "Programmable protein delivery with a bacterial contractile injection system" by Feng Zhang's lab. https://t.co/Cm8XDPQpJv
0
0
8
Our DREAM paper is out: We found the first master regulator of DNA repair capacities! Read and re-tweet now: The DREAM complex functions as conserved master regulator of somatic DNA repair capacities, @CECAD_ @UKKoeln @UniCologne
https://t.co/rVMe4rAxaf
nature.com
Nature Structural & Molecular Biology - In this work, the authors show that the DREAM complex suppresses the expression of numerous DNA-repair proteins in somatic cells. Suppression of the...
69
341
1K