Marco Buttigieg
@marcobuttigieg_
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MD/PhD student in the Rauh Lab at Queen’s University | Vanier Scholar | Clonal hematopoiesis, inflammation, aging, and cancer
Kingston, ON
Joined April 2023
I'm super excited to share that our work on clonal hematopoiesis in the tumour microenvironment is now published in @CellRepMed!!. By tracking CH mutations from the blood into the tumour (CH-Tum), we uncovered some new insights about CH in solid cancer.
cell.com
Buttigieg et al. demonstrate that the infiltration of somatically mutated leukocytes—clonal hematopoiesis (CH)—into the tumor microenvironment can lead to poor outcomes across solid tumors. By...
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RT @EricTopol: There are much more structural variants within our genomes than previously conceived, >26,000 per person..
nature.com
Nature - Using sequencing and haplotype-resolved assembly of 65 diverse human genomes, complex regions including the major histocompatibility complex and centromeres are analysed.
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RT @QueensuSCRI: We're super excited to announce the 10 recipients of our @QueensuSCRI INAUGURAL 2025 Sinclair Graduate Scholars in Cancer….
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RT @TrowbridgeLab: Delighted to share an updated review and our perspectives on clonal hematopoiesis and cancer in @NatureCancer in collab….
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RT @yash_pershad: We are excited to share our work on "closing the loop" 🔄 - a framework enabling single-cell foundation models (scFMs) to….
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I'm honoured to share that I've been selected as part of the final @CIHR_IRSC #VanierCanada CGS cohort! Very grateful for the support from my supervisors @QMyPath and Rob Vanner, as well as family, friends, and mentors from along the way! .@QueensMDPhD @QueensuSCRI @QueensUHealth
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RT @QMyPath: Congrats & thanks to Katherine King & Katie Matatall @TheKingLab for inviting us to this collaboration @CellStemCell. Also to….
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RT @juliabelk: Collaborative work online now @CellStemCell provides insight into how mutant immune cells can help mitigate Alzheimer’s dise….
cell.com
Matatall et al. uncover a mutation-specific association between clonal hematopoiesis (CH) and Alzheimer’s disease (AD) in mice and humans. TET2-mutant CH conferred lower odds of AD in humans and...
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RT @EricTopol: Clonal hematopoiesis (CH, blood stem cells with mutations) is considered a risk factor for cardiovascular disease and other….
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RT @DrKTakahashi: 🚨 New paper in @NatureGenet !.How does cancer chemotherapy reshape the HSC landscape and drive the evolution of therapy-r….
nature.com
Nature Genetics - Analysis of whole-genome sequencing data from hematopoietic stem and progenitor cells taken from patients with myeloma shows how treatment shapes clonal architecture and sheds...
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RT @DrDominicNg: Scientists @CellPressNews reviewed 408 YouTube clips of sleeping cats and found 2/3 curled up on their left side. Here’s….
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RT @angelica_varesi: Excited to announce our latest preprint is finally out! Huge collaborative work shared with @MurtazaNagree and supervi….
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RT @oncology_bg: Such a well deserved standing ovation for Chris Booth and the Challenge trial. These data are quite powerful. Much stronge….
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RT @oncology_bg: The most practice changing trial from #ASCO25 is now live on @NEJM .If this was a drug, this would be approved today. Glob….
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RT @SuyogCancer: What if this was a drug ?🙂 . 🆕 NEJM | June 2025.🎯 CHALLENGE Trial: Structured exercise after adjuvant chemo in colon can….
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RT @AlejoFraticelli: Absolutely thrilled to share with you the final version of EPIclone, out now (open access) in @Nature. This has been….
nature.com
Nature - The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell...
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RT @andygxzeng: Excited to see BoneMarrowMap out in press! . Please check out the R package (now capable of classifying 100,000 hematopoiet….
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Phenomenal paper from @oriol_pich @Elsa2Bernard out in NEJM exploring tumour-infiltrating clonal hematopoiesis! . Many interesting findings complementary to our work in Cell Reports Medicine connecting TI-CH/CH-Tum with worsened clinical outcomes and dysregulated myeloid immunity
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RT @QMyPath: Trio of studies, including this, ours & @rosslevinemd group. Tumor-infiltrating clonal hematopoiesis (TI-CH or CH-Tum) leads t….
biorxiv.org
Anaplastic thyroid cancer (ATC) is a clinically aggressive malignancy with a dismal prognosis. Combined BRAF/MEK inhibition offers significant therapeutic benefit in patients with BRAF V600E-mutant...
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