Loyal
@loyalfordogs
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We’re developing the first drugs intended to help dogs live longer, healthier lives 🐕
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We announced a major milestone with the FDA today.
Watch below to learn what this means for large-breed dogs everywhere.
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Big news for big dogs — Loyal just hit a historic milestone with our drug to help large-breed dogs live longer and stay healthier as they age.
Read all about it in our blog:
@nytimes
@WIRED
@BusinessInsider
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We’re excited to announce that we’ve successfully completed our Series B funding and have raised another $45 million in investment bringing our total funding to $125M+.
Special thanks to
@BainCapVC
@khoslaventures
@firstround
@boxgroup
@collabfund
@quietcapital
among others.
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Big day here at Loyal. Behind the scenes with
@celinehalioua
and our lovely dog models, including Louise and Gertie from
@Muttville
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Great article in
@NatGeo
on dog longevity, highlighting our work at Loyal,
@mkaeberlein
and the
@DogAgingProject
, and our friends at
@Muttville
👏🏼
"Could Fido be our best hope to reverse aging in humans?" via
@FranSmithwrites
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29
When animal lover
@jonstewart
heard about Loyal and our work on extending dog lifespan and healthspan, he invited CEO
@celinehalioua
to discuss dog longevity, aging disease, and implications for humans too. Tune into the latest episode of
@theproblem
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We’re celebrating good news: Loyal received something called protocol concurrence from the FDA.
What does this mean exactly? (1/3)
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It’s official…we’re headed to
#SXSW
!
You won’t want to miss our CEO
@celinehalioua
discuss the latest in longevity science with
@LauraDeming
and
@andreamvaldez
from
@TheAtlantic
.
Spoiler alert: we’ve got some exciting news to share with you on stage 😉
See you soon, Austin!
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Did you know giving your dog a Valentine’s Day smooch can elevate their feel-good hormones like serotonin, dopamine and oxytocin — just in case you needed another excuse. 💓
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What is LOY-002 and who is it for?
→ LOY-002 is our longevity drug for dogs of all breeds and sizes — specifically, senior dogs weighing 14 pounds or more
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Could your dog be the future face of our first FDA-approved lifespan extension drug? To apply:
→ Your dog must be over 10 years old and at least 14 lb, or over 7 years old and at least 40 lb
→ You must be able to get to Orlando / Tampa
→ You must be available 5/15-5/17
(1/2)
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Expanded conditional approval (XCA) is a new regulatory pathway that allows certain animal drugs to be conditionally approved based on providing:
1. Full safety data,
2. Full manufacturing data, and
3. Reasonable expectation of effectiveness.
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Is there a tool to measure aging? How do you know how quickly your dog is aging? It can’t be as simple as 7 dog years for every human year, and we can tell you — it’s not! (1/4)
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Why do big dogs live much shorter lives than small dogs? Learn how genetic differences impact age in our latest blog post by Loyal's Director of Veterinary Medicine,
@SkeptVet
→
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Join Loyal Founder / CEO,
@celinehalioua
, and other industry experts discuss the future of longevity and aging at the 2022 Longevity Summit, December 6-7.
Register for the event today using code “Loyal” for 20% off at checkout:
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Yesterday, Loyal Senior Scientist James McMahon presented our results at Keystone Symposia: Molecular Basis of Healthy Aging, discussing our study on aging biomarkers in dogs, and how these findings relate to human aging.
Read the study highlights here →
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Over a lifetime, how many times does your dog see the vet? And how many other dogs does your vet see? 🏥
Now take all the health data from those visits and millions more — that’s the scale of a dataset we're working with in collaboration with
@Banfield
Pet Hospital.
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Attention 'fur-ends'! 🐶🐾
Do you know what this Thursday is?
It’s International Dog Day!
To celebrate, we’ll release some chapters of our Aging Primer, a canine-centric introduction to aging.
Here is Chapter 1: What Is Aging?
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“[Loyal] has set a possible precedent for other drugs to be approved for lifespan extension, potentially opening a door for other animal—or human—drug companies to follow.” -
@alexjanin
via
@WSJ
ICYMI, read more about our recent progress with the FDA:
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Last week was a big one for Loyal! 🎉
1 - We were on the front page of
@sfchronicle
👏🏼 Thanks to
@CSaid
for covering the story of Loyal.
Read the full article here:
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Loyal’s Director of Vet Med, Dr. Brennen McKenzie, discusses the work we’re doing at Loyal on what will “probably be the largest clinical trial in veterinary medical history” —
🐕Dogs could have their healthy lifespan extended as part of a Silicon Valley trial.
Find out more here:
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We’d love to come back to
#SXSW
2024! Cast your vote for our panel: “Could Dogs be Key to Unlocking Human Longevity?” Our Founder & CEO
@celinehalioua
will be joined by
@mkaeberlein
from
@DogAgingProject
and
@andreamvaldez
from
@TheAtlantic
to dive into all things dog longevity.
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Big congrats to our founder + CEO,
@celinehalioua
, for making the
@SFBusinessTimes
40 Under 40 list 👏😍
#SaveTheDogsSaveTheWorld
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Calling all dog lovers going to
@sxsw
!
Join Loyal CEO
@celinehalioua
on March 9, 11:30AM at JW Marriott to discuss dog aging and longevity — and what dogs can teach us about human longevity.
You can find the session details here —
#SXSWPresenter
#SXSW
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Big
@akcdoglovers
news: Lancashire Heelers were accepted to be the 201st breed of the AKC in the Herding group — effective in 2024. At 9-17 lbs, and 10-12 in tall, they're the new smallest Herder. 🥹
This is Gambit, a Lancashire Heeler featured on our website. Congrats, buddy.
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“Part of Celine and Loyal’s brilliance is that they found a completely different path...that lets her focus solely on the drugs’ antiaging properties right from the start."
Check out
@tsimonite
's latest article in
@WIRED
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We’re so grateful to Dr. Coby Rudakewiz & the Animal Hospital of Dauphin County for being our partners in the STAY study.
Their team has partnered with us on multiple studies, including two of our studies in 2021 & 2023. Now we’re excited to collaborate on our largest study yet.
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That's exactly what we're saying,
@JonStewart
🐕. Great interview with
@CelineHalioua
via
@TheProblem
on the ideas behind Loyal and dog longevity. Listen to the full episode here:
“What you’re saying is all dogs go to heaven, but you would just like to make them go a little later?” –
@JonStewart
talks with
@LoyalForDogs
Founder and CEO
@CelineHalioua
about her efforts to extend the lifespan of dogs. Full episode on
@ApplePodcasts
:
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Here’s what a life extension drug would mean to large-breed dog owners and their pups. ❤️
Big thanks to all the pet owners who shared their excitement for our recent announcement.
What would a life extension drug for your dog mean to you? 🧵
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3 - We had our latest brand photoshoot in Austin with our amazing new dog models and their pet parents 📸
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Our pilot study for LOY-002 is now fully enrolled — another big milestone achieved. Read our blog post to learn more about how this study gets us closer to bringing dog longevity drugs to market:
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Busy day here at
@fetchdvm360
Long Beach! If you’re here, make sure to stop by Booth 1118 to say hi to our veterinary team.
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Cast your vote for our
#SXSW
panel: "A Dog’s Life: Longevity Science Gets Serious,” where Loyal Founder & CEO
@celinehalioua
will be joined by Bloomberg’s
@ashleevance
&
@LauraDeming
of The Longevity Fund to discuss the latest in dog longevity 🐕
→
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Dr. Brennen McKenzie is giving another highly-anticipated talk
@ACVIM
on the Effects of Nutritional Interventions in Aging. Hear the latest evidence on diet and age-associated disease prevention, the heroes and villains of metabolism, and more on June 15 at 11:15 AM in PCC 103BC
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These funds fuel our mission to bring an FDA-approved canine longevity product to market. Thank you to our investors — both old and new — for believing in and supporting our mission to help dogs live longer and healthier lives.
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When Mazel was adopted, his pet parent Abigail didn’t know his age. Through our X-Thousand Dogs study, we used methylation, a useful tool for assessing health + longevity, to give Abigail a more accurate picture of how his environment affects his aging. →
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Vets and vet techs have burning questions to ask, and our Director of Clinical Development has burning answers to offer.
Read our most frequently asked questions from vets on our aging theses and products. →
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Happy for our partners,
@Crinetics
! We’re excited to see such positive Phase 3 results in humans with acromegaly — fills us with enthusiasm as we continue our work to develop a similar Crinetics compound that could help dogs live longer, healthier lives.
Positive results from our PATHFNDR-1 study suggest our investigational, once-daily, oral
#paltusotine
, if approved, could represent a new treatment alternative for people with
#acromegaly
$CRNX
#crinetics
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Happy International Dog Day! Today we want to share ways to keep your dog healthier and living longer. Here is Chapter 5 from the Canine Aging Primer: What Can We Do About Aging in Dogs?
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BYOD (bring your dog 🐶) and join Loyal CEO
@celinehalioua
and
@SinaHartung
of
@EurekaHealthApp
for drinks at our HQ, where we’ll be surrounded by incredible women in health and biotech. Join us today from 3-5pm.
@SFTechWeek
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We’re one day away from International Dog Day, so we’re sharing another chapter from our Aging Primer with you. Here is Chapter 2: How Does Aging Affect Dogs?
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To ensure our drugs are safe and effective, we’re engaged in a complex, multi-year approval process with the FDA. With protocol concurrence, as designed, our study will validate whether our drug extends canine lifespan and healthspan... (2/3)
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...If the drugs work as intended, the FDA will consider our study sufficient to support full FDA approval.
This is a giant step for us on the path to getting our first drug approved and helping dogs live longer, healthier lives.
Learn more here: (3/3)
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Join our aging biologist
@philfrankino
today at 2-3pm EDT as he presents the results of our Healthspan Study, a cross-sectional aging biomarker study in companion dogs, at
#GSA2022
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Don't forget to follow us and join the Loyal pack for more content, dog memes and, most importantly, updates on how we're trying to extend healthy life for our Loyal companions!
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Who's coming to
#SXSW2023
? Mark your calendars for A Dog's Life: Longevity Science Gets Serious to catch Loyal’s first FDA milestone announcement 📣🚨 →
sharing big Loyal FDA news - the first FDA milestone we're talking about publicly - next week :)
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Learn more about veterinary geroscience and the impact of aging on animals and humans from Loyal's Director of Veterinary Medicine, Dr. Brennen McKenzie, in the latest episode of Veterinary Vortex:
Don't miss the latest episode of Veterinary Vertex! 🎙️
Learn about veterinary
#geroscience
and how
#aging
affects humans and animals with Dr. Brennen McKenzie:
@SkeptVet
@loyalfordogs
#podcast
#OneHealth
#vetmed
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The primer, written by our very own Dir of Vet Med,
@SkeptVet
, introduces some key concepts of canine aging and what we can do to help our furry friends live longer.
Head over to to read the full chapter!
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Next up, meet Atlas!
He’s an energetic, friendly Pit Bull mix who participated in two Loyal studies — our Healthspan study and the LOY-002 pilot study. It was a pleasure to welcome him back again.
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🧵🐕 To celebrate having fully enrolled our pilot study, we’d like to introduce you to a few of our amazing canine study partners:
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You can read more about our most recent study in aging biomarkers and how it translates between dogs and humans here → (4/4)
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Here’s a great read in
@techreview
highlighting our own
@celinehalioua
and the work we’re doing at Loyal, amongst those profiled in “These scientists are working to extend the life span of pet dogs—and their owners” via
@JessHamzelou
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Learn more about what this means for our products → →
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Join the Loyal team at Fetch Kansas City on August 26-28, 2022. Meet us at Booth 710 and discover how participating in clinical trials can help us help dogs everywhere—and benefit your practice too.
We can't wait to see you there!
Learn More at .
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What’s even more exciting is that aging biomarkers can be leveraged to assess the effectiveness of an intervention used to treat aging. Solving this question can potentially support Loyal’s clinical trials and longevity research everywhere. (3/4)
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We’re returning to VMX from Jan 13 to 17! Learn more about the drugs we’re developing to help dogs live longer and maintain their quality life as they age.
Come meet our veterinary team at Booth 642, and don’t forget to pick up a little gift from us to thank you for stopping by.
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Our inimitable Dr. Ellen Ratcliff is gearing up to present on our recent studies on a Cross-sectional Investigation of Potential Biomarkers of Aging in Dogs. If you’re attending
@ACVIM
on Jun 16, come by Room PCC 108B at 4:30 PM EST to learn about these hallmarks of aging in dogs
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Fetch Long Beach is almost here!
Meet our veterinary team at Booth 1118 and learn more about the drugs we’re developing to extend healthy lifespan in dogs.
We’ve got some gifts to share with you for stopping by as well — hope to see you there!
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“My goal is to introduce veterinarians to a new way of thinking about aging, as something that's not inevitable but as just another modifiable risk factor for many of the diseases we see in older dogs.”
- Dr. Brennen McKenzie, Loyal's Director of Vet Med
Tune in tonight for a
#sponsored
#webinar
and review the fundamental principles of canine aging – how and why dogs age, when a dog should be considered senior, and what approaches we should take to extend the lifespan and healthspan in dogs.
@loyalfordogs
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If you're at WVC, don't forget to stop by today to see Dr. Ellen Ratcliff present Loyal's approach on addressing lifespan and healthspan in dogs.
3pm @ the Learning Lounge in Exhibit Hall, Level 1
Our very own Dr. Ellen Ratcliff is presenting on our approach to address lifespan and healthspan in dogs at WVC. Ellen brings 17 years of mixed animal practice experience to Loyal, and she’ll share Loyal’s mission from the vet perspective.
WVC Learning Lounge @ 3pm on Tues, 2/21
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This question around measuring aging is a tricky one that people in both the human and dog space are trying to tackle. At Loyal, we’ve found similarities between the two — blood markers to measure aging in dogs are similar to those in humans. (2/4)
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Watch the interview on YouTube:
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→ We’ve just launched the STAY clinical study for LOY-002 in partnership with 50+ veterinary clinics across the country
Learn about the STAY study:
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The conditional approval pathway is intended for animal drugs that address an unmet medical need and require particularly complex studies to complete collection of the effectiveness data needed for full approval.
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This is Darcy, who participated in our Healthspan study. 👋🏼
Did you know corgis like Darcy are the 11th most popular breed in the US right now?
#DogsOfLoyal
#VeterinaryMedicine
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Read more about our recent FDA milestone for large-breed dogs →
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Here’s your chance to meet Loyal’s Director of Vet Med, Dr. Brennen McKenzie at
#WVC2023
where he’ll talk about evidence-based geriatric medicine in dogs among other topics on Wednesday, 2/22. Hope to see you there!
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"Saying goodbye to our pets might not have to come so soon if we can keep them healthier for longer."
Read about Loyal's efforts to help dogs everywhere in
@IFLScience
via
@The_RHF
→
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@Banfield
Together, this information can help us understand our pets’ well-being and shape a brighter future for them.
Discover how we’re helping dogs stay healthier as they age —
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Did you catch
@celinehalioua
on
@WakeUpCallKFI
this morning? Our CEO joined
@jjlkfi
to discuss all things Loyal and what our team is working on to help dogs age better and ultimately live longer lives.
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View the full chapter:
That’s all for this week. Thanks for celebrating with us! 🐶🐾
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Loyal is coming to
#VMX2023
on Jan 14-18! Meet our team of veterinarians at booth 4640 and discover how you can partner with us to develop drugs intended to extend canine lifespan and quality of life.
Learn more at . We can't wait to meet you in Orlando🎉
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First up, meet Ava.
Ava is 32.7% Catahoula Leopard Dog, which puts her in the 53% of dogs in the US that are mixed breed. We love her curious expression and liver-colored nose.
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Thanks
@fetchdvm360
for having us at the Fetch Kansas City Conference and to everyone who stopped by the Loyal booth. We look forward to seeing you again soon!
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Read Mazel’s story and more about the results from our X-Thousand Dogs study from
@Axios
via
@AlisonMSnyder
→
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Vets at WVC—don't miss Dr. Brennen McKenzie's talk today on evidence-based geriatric medicine in dogs.
@ 10:35am in Mandalay Bay, Level 2
Here’s your chance to meet Loyal’s Director of Vet Med, Dr. Brennen McKenzie at
#WVC2023
where he’ll talk about evidence-based geriatric medicine in dogs among other topics on Wednesday, 2/22. Hope to see you there!
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Beso is a handsome Greyhound with a sweet disposition who participated in our Healthspan pop-up clinic collaboration with All Vets Great and Small and Muttville. ♥️
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Plus, don’t miss our peer lunch event at 12:15pm on Sunday 8/28, where Loyal’s Director of Veterinary Medicine, Dr. Brennen McKenzie, VMD will present on Aging in the Dog: Foundations of Canine Geriatric Medicine.
@SkeptVet
@fetchdvm360
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Head to our latest blog post for more info:
Welcome to the team, Blake!
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“We’re hoping to show that we can both increase the length of life, and more importantly, the length of time these dogs live healthy and happy and functional lives.” — Dr. Brennen McKenzie (
@SkeptVet
) on our upcoming clinical trial of 1,000 aging dogs
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Thanks
@TurnerNovak
for having us on
@ThePeelPod
!
🎧🍌 New
@ThePeelPod
with
@celinehalioua
Celine is the Founder and CEO of
@loyalfordogs
, developing drugs to help dogs live longer, healthier lives.
We talk all things longevity, getting FDA approval, building a biotech startup and how it’s different than software, creating a…
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