Lakhansing Pardeshi
@lakhanp01
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(PhD Candidate ⊂ ((Pangenomics ⋃ Bioinformatics) ⊂ {Pathogens})) ⊂ {@WUR}
Netherlands
Joined October 2017
Published in @MicrobioSoc
https://t.co/Cp0GR0hb74 highlighting: - Contribution of #prophage dynamics in the #pangenome evolution - Pangenome data structure to trace orthologous prophages - Generalist & specialist prophages in the Pectobacterium genus
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Excited to share our research where we trace prophages in the Pectobacterium genus pangenome to understand their contribution to genomic heterogeneity.
Pangenomics to understand prophage dynamics in the Pectobacterium genus and the radiating lineages of P. brasiliense https://t.co/pUbIZ9PNka
#biorxiv_bioinfo
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Ten interesting things we learned about phages while editing this article for @AsimovPress: 1. You can buy phage therapies over-the-counter at some pharmacies in Georgia. (The country. Not the state.) 2. An oft-cited estimate is that by 2050, at least ten million people could
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Highly informative talks on ANI, species diversity and obviously the pangenomics…
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Excited to share a paper on a novel chromatin complex that connects Fungal Development and Secondary Metabolism. Made possible with collaborative efforts from many labs @TheKellerLab, @StraussFungiLab, #StefanGraessl, @alhussainm01, led by @obayram54.
academic.oup.com
Abstract. Chromatin complexes control a vast number of epigenetic developmental processes. Filamentous fungi present an important clade of microbes with po
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👋 I've made a new #dataviz related website! 😀 It's called☀️ https://t.co/vK63kNuQJl: a list of many stunning Viz projects I love💜 🧵
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Our story on how orthologous gene #coevolution 🧬 can be used to provide insight into cellular and genomic structure and function is now published in @ScienceAdvances 😊😊 A 🧵 summary 🔗: https://t.co/jMGpRGPNdw
#evolution #biotech #science #research #molecularbiology #biology
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How cool is this! Soil fungus uses a bacterial metabolite (produced endocymbiotically) to protect against nematodes! Bacterial endosymbionts protect beneficial soil fungus from nematode attack
pnas.org
Fungi of the genus Mortierella occur ubiquitously in soils where they play pivotal roles in carbon cycling, xenobiont degradation, and promoting pl...
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Excited to share our study defining the #pangenome of Aspergillus fumigatus and what it told us about virulence and drug-resistance! Out now in @NatureMicrobiol.
OUT NOW: Aspergillus fumigatus pan-genome analysis identifies genetic variants associated with human infection. By Oliver Kurzai, Gianni Panagiotou & colleagues. @frau_dr_barber @okurzai @leibnizhki @uni_wue #fungi Read it here: https://t.co/eNf41UygOo
https://t.co/YVhqeL5pA5
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In our new paper we describe patterns of mutation accumulation in a fungal pathogen. One year of cell divisions and evolution in 280 isolates including mutants impaired in heterochromatin formation, and isolates with/without DNA methylation. See:
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Proud to share our latest work on #Candida glabrata identifying a transcription factor important for #macrophage_response and #drug_resistance. By a team of talented post docs and students. https://t.co/oFkoGNC1Yz
biorxiv.org
Candida glabrata can thrive inside macrophages and tolerate high levels of azole antifungals. These innate abilities render infections by this human pathogen a clinical challenge. How C. glabrata...
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Excited to share our paper showing how Aspergillus spores proactively prepare for their future (through staying transcriptionally active and responsive) before entering dormancy. By a talented PhD student (Fang Wang) with helps from other lab members.
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Taking time to savour this moment: my first senior author paper published today in Genome Biology. I'm incredibly proud of this work & I couldn't have done it without @JovMaksimovic. Thanks @AliciaOshlack for allowing me the space & time to lead this work.
genomebiology.biomedcentral.com
DNA methylation is one of the most commonly studied epigenetic marks, due to its role in disease and development. Illumina methylation arrays have been extensively used to measure methylation across...
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“We were quite gobsmacked by how much repetitive DNA was in there due to these transposable elements”
genestogenomes.org
Over 90 percent of the genome of this pathogen threatening Australian ecosystems is made of transposable elements. Myrtle rust (Austropuccinia psidii) is a pathogenic fungus that has spread rapidly...
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Samplot: from @jon_belyeu, Chowdhury, @ryanlayer and co, for visualizing read alignment at suspected structural variants, to aid manual curation of SVs. Human input is a good way of resolving false positives from automated SV callers. https://t.co/HIb6AqCq5m
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from 5 GB to 74MB is the difference between the gzip and xz (lzma) formats for storing the 1.4m SARS-CoV2 genomes. This file would have taken 39GB uncompressed.
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Just out in @PNASnews secondary metabolite gene clusters of >1,000 fungi 🍄🧬 reveal distinct chemical reservoirs important for drug-discovery and the evolution of #fungi. #Genomics In collaboration with @NLKproteomics: https://t.co/0XkhmfTdF3 Ft. @hailceezur @MTDrott
pnas.org
Fungi are prolific producers of natural products, compounds which have had a large societal impact as pharmaceuticals, mycotoxins, and agrochemical...
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Chromatin profiling reveals genome stability heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus https://t.co/sZeRKROtr0
#bioRxiv
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