RT @dbikard: Eligo Bioscience is hiring for the following roles: .Senior Biochemist Scientist.Microbial Synthetic Biologist.Bioinformatics….

RT @EricTopol: The ability to manipulate the gut microbiome was restricted to pre- and probiotics,FMT. Now there's successful #CRISPR base….

RT @GENbio: Researchers at Paris-based @EligoBio have engineered a phage-derived vector to deliver a base editor and modify E. coli while t….

RT @dbikard: 1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base edit….

RT @genomicsdoc: Cool new work from @EligoBio.

Thank you @CrisprMedicine for the article!.

With this work we show that the targeted mutagenesis of gut bacteria in situ - something that was inconceivable before - can actually be done! . There is now an exciting road ahead for @EligoBio to develop first in class drugs based on this strategy. #ImmunoInflammation #Oncology.

💯 Experiments in a mouse model of E.coli gut colonization showed indeed that up to 99.7% of target bacteria can be edited, without selection and without maintenance of a transgene. ⌛️Edits remain stable for at least 42 days!!!! (more data to come…)

3/ Finally, we engineered a novel genetic system ensuring that the plasmid we deliver cannot replicate in the recipient bacteria (to prevent dissemination). As a result the base editor is expressed only very transiently, yet this is enough to edit the whole target population!!!!

2/ We then packaged in these engineered phage capsids a synthetic plasmid encoding a base editor, programmed to inactivate an antibiotic resistance gene present in the target bacteria’s genome. 💯 The resulting Eligobiotics can edit 99.99% of a target E. coli in vitro.

1st/ Our team engineered the receptors of bacteriophage lambda’s capsid to significantly increase the efficiency with which it injects a synthetic DNA payload to E. coli in the gut environment.

❓❓Could we engineer a modality to deliver gene editors to enough bacteria to have a meaningful effect?.❓❓❓Once inside the target population, would the editing efficiency be high enough?.👍 The answer to these questions is a resounding YES!.

Scientists are unraveling causal effects between bacterial genes and serious diseases at an accelerating pace. ❓But is it even conceivable to precisely edit the genome of bacteria directly in the gut?.

The last decade has seen amazing progress in gene editing and delivery strategies for human cells, leading to promising clinical developments. But genes in human cells are not the only ones in our bodies that matter.

🚀 Very excited to share this work from our amazing scientists at @EligoBio. 🧬 We show that targeted mutations can be introduced with high efficiency directly in the gut microbiome - even without the need for selection!.Thread below.

Exciting times for Eligo with favorable and decisive ruling from the USPTO in interference case on CRISPR-Cas antimicrobials.

Hello microbiology and molecular biology students in the EU! Are you looking for an internship to improve your lab skills while making meaningful contributions to exciting new drug projects? Eligo wants to hear from you, we are recruiting!  #microbiome.

It's an exciting day at Eligo! We have presented data demonstrating that our lead drug candidate, EB003, could alleviate symptoms in 100% of treated animals in a disease-relevant model.

Welcome to the team @HesselEdith.#InternationalWomensDay #GoGoEligo!.

RT @GSK: We are delighted to join forces with @EligoBio, a biotech company that is pioneering #microbiome engineering. With this partnershi….