Eligo Bioscience
@EligoBio
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Developing new precision medicines to treat the microbiome | WEF Technology Pioneer | #SyntheticBiology #CRISPR #Phages #GeneTherapy #Microbiome
Paris, Boston, New York
Joined July 2015
Eligo Bioscience is hiring for the following roles: Senior Biochemist Scientist Microbial Synthetic Biologist Bioinformatics Scientist Regulatory & Quality Manager Join us in shaping the future of precision microbiome medicines!!!! Apply here: https://t.co/CtBTouTkL1
@EligoBio
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The ability to manipulate the gut microbiome was restricted to pre- and probiotics,FMT. Now there's successful #CRISPR base editing https://t.co/EdjwWQwyeV
@justsaysinmice
@Nature @EligoBio @dbikard @duportet
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Researchers at Paris-based @EligoBio have engineered a phage-derived vector to deliver a base editor and modify E. coli while they are colonizing the mouse gut. Learn more: https://t.co/0nFRWPqzwA
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1/ 𧡠Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut π¦ π‘ #Microbiome #SyntheticBiology
https://t.co/efTztuluN9
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Cool new work from @EligoBio.
Scientists have designed a gene-editing tool that can modify bacterial populations in the gut microbiome of living mice
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Thank you @CrisprMedicine for the article!
ππ«πππ€π’π§π : ππ₯π’π π¨ ππ’π¨π¬ππ’ππ§ππ πππ©π¨π«ππ¬ π
π’π«π¬π-ππ―ππ« π’π§ ππ’π―π¨ ππ’ππ«π¨ππ’π¨π¦π πππ¬π πππ’ππ’π§π In an article published moments ago in Nature, the company demonstrates for the first time ever that it is possible to target a
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With this work we show that the targeted mutagenesis of gut bacteria in situ - something that was inconceivable before - can actually be done! There is now an exciting road ahead for @EligoBio to develop first in class drugs based on this strategy. #ImmunoInflammation #Oncology
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π― Experiments in a mouse model of E.coli gut colonization showed indeed that up to 99.7% of target bacteria can be edited, without selection and without maintenance of a transgene. βοΈEdits remain stable for at least 42 days!!!! (more data to comeβ¦)
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3/ Finally, we engineered a novel genetic system ensuring that the plasmid we deliver cannot replicate in the recipient bacteria (to prevent dissemination). As a result the base editor is expressed only very transiently, yet this is enough to edit the whole target population!!!!
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2/ We then packaged in these engineered phage capsids a synthetic plasmid encoding a base editor, programmed to inactivate an antibiotic resistance gene present in the target bacteriaβs genome. π― The resulting Eligobiotics can edit 99.99% of a target E. coli in vitro.
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1st/ Our team engineered the receptors of bacteriophage lambdaβs capsid to significantly increase the efficiency with which it injects a synthetic DNA payload to E. coli in the gut environment.
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ββCould we engineer a modality to deliver gene editors to enough bacteria to have a meaningful effect? βββOnce inside the target population, would the editing efficiency be high enough? π The answer to these questions is a resounding YES!
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Scientists are unraveling causal effects between bacterial genes and serious diseases at an accelerating pace. βBut is it even conceivable to precisely edit the genome of bacteria directly in the gut?
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The last decade has seen amazing progress in gene editing and delivery strategies for human cells, leading to promising clinical developments. But genes in human cells are not the only ones in our bodies that matter.
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π Very excited to share this work from our amazing scientists at @EligoBio. 𧬠We show that targeted mutations can be introduced with high efficiency directly in the gut microbiome - even without the need for selection! Thread below...
biorxiv.org
Microbiome research is revealing a growing number of bacterial genes that impact our health. While CRISPR-derived tools have shown great success in editing disease-driving genes in human cells, we...
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Exciting times for Eligo with favorable and decisive ruling from the USPTO in interference case on CRISPR-Cas antimicrobials. https://t.co/BS4FTxkYMz
eligo.bio
Paris, France, Dec 2, 2021: the US Patent and Trademark Office (USPTO) has issued a decision and a judgement acknowledging priority to the invention of precision bacterial killing using CRISPR to The...
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Hello microbiology and molecular biology students in the EU! Are you looking for an internship to improve your lab skills while making meaningful contributions to exciting new drug projects? Eligo wants to hear from you, we are recruiting!Β https://t.co/dB7Pk0XQzy
#microbiome
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It's an exciting day at Eligo! We have presented data demonstrating that our lead drug candidate, EB003, could alleviate symptoms in 100% of treated animals in a disease-relevant model. https://t.co/OWfsvqRaIi
eligo.bio
Paris, France - Eligo Bioscience SA (Eligo) today announced positive in-vivo data generated using their highly differentiated CRISPR-based antimicrobial platform.
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We are delighted to join forces with @EligoBio, a biotech company that is pioneering #microbiome engineering. With this partnership, Eligoβs #CRISPR technology will be accelerated thanks to our scientific excellence and capabilities π
#News: We are proud to announce a partnership worth up to $224M with @GSK to develop a CRISPR-based microbiome therapy for the millions of patients suffering of acne every year. https://t.co/YcB0DxSHQi
#Microbiome #Inflammation #Acne #Crispr
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