Alexander Hynes
@APHage_
Followers
979
Following
1K
Media
49
Statuses
556
Father of Five. (he/him). Bacteriophages are amazing. Associate Professor, McMaster University.
Hamilton, Ontario
Joined July 2019
As I polish up my resubmission, I also reflect on the 'mistakes' of my initial CIHR project grant. If a limerick can ever be a mistake...
0
0
15
Two surprises hiding in our latest! (1) How broadly effective Piperacillin is at synergizing with temperate phages. Maybe a reason PTZ is so effective? (2) Our inability to correlate any likely predictors of tPAS to actual synergy.
journals.asm.org
The recent discovery that otherwise therapeutically unusable temperate phages can potentiate the activity of antibiotics, resulting in a potent synergy, has only been tested in E. coli, and with a...
0
0
12
"Now that you've reviewed for us for free, would you also complete this short survey on the review process that will only take 12-15 minutes?"
1
0
3
Dr. @rabiafatima_ has "tPASsed". Too many feels. Thank you @implosian - sorry you couldn't make it for the presentation of the warhammer. I do get asked if I fear the graduates will use them against me... no! Not in public, anyway - they're all far too smart to get caught.
3
1
28
Another double-podium finish for the Hynes Lab! The costume is a bit of an in joke/homage to @Yingfu8888, while the pumpkins... well, I'd say they speak for themselves, although having "Bye Bye Bye" playing out of the speaker added a nice touch.
0
0
7
The night before NoR. Last week at @CSM_SCM2024 I met many fantastic researchers in this competition, in the same panel. And for 85% of us, tomorrow is going to suck. What's the better way forward?
0
0
6
I'd love for some of you who have done massive screens (@baym, @AHarms485, for example) to give this a look. It's a really simple concept, and works *way* better than I thought it would. I never expected we could see plaques at this resolution.
4
1
17
A picture is worth 1536 plaque assays. While we used a robot, we also tried a dirt-cheap 3D-printed alternative which works wonders at 384-density. I really believe this pre-print has the potentially to be the largest impact I will make on my field. https://t.co/49LaoV1fMD
5
52
201
If you've induced phages, you may have wondered if you can do the opposite: block entry into lysogeny. You can, using protein synthesis inhibitors! This yields a potent synergy, functionally turning a temperate phage into a virulent one. @APHage_ #mBio
https://t.co/BPYFNEFzKk
0
4
26
If you've induced phages, you may have wondered if you can do the 'opposite' - block entry into lysogeny. You can, using protein synthesis inhibitors! Better still, this yields a potent synergy, functionally turning a temperate phage into a virulent one. https://t.co/nkLBhPL1XD
0
31
99
That's one impressive host range, and not even in the top 5 coolest things about this story.
For example, the prototypical IncP plasmid-dependent phage PRD1 has a very generalist host range, and can infect most g-proteobacteria carrying an IncP plasmid. PRDcerulean is 95% identical to PRD1 but has a very narrow host range, mostly restricted to Pseudomonas (4/ )
1
8
29
Et de deux! @DNADoubleFelix presenting the spoils of his PhD - Warhammer, Phage-Planters, and DNA. Oh, and a Thesis, I suppose. A masterful defence, a wonderful external @jwmodell... and there goes the last of the lab's starting cohort. *sniff*.
3
2
35
Ladies, Gentlemen - I present to you the first PhD out of the Hynes Lab - congratulations Dr. Al-Anany!
18
15
542
I am thrilled to share our work on a novel prophage-encoded phage defence from @theMaxwellLab: Anti-phage defence through inhibition of virion assembly https://t.co/qgzR97s4KH
nature.com
Nature Communications - Bacteria have evolved various defence mechanisms to protect themselves against viral infection. Here, Patel et al. identify a type of antiviral defence that blocks virion...
6
48
132
Oh dear. it looks exactly like what I would scribble if I were asked to draw a JAK-STAT pathway in an exam today. Uncanny.
0
0
7
🏆 Karen Maxwell @UofT wins an Arthur B. McDonald Fellowship in recognition of world-leading contributions to bacteriophage research and its applications. ▶️ https://t.co/2208tB9OMw
4
12
69
The Hynes Lab Halloween! Even with a song and routine, we couldn't overthrough the reigning champion Li Lab in the costume contest, although we did claim victory in the Pumpkins!
0
0
26
I don’t get this whole “correlation is not causation” thing. Every time I see a correlation, it seems to be causative.
25
5
95
An amazing poster by @JoseTamina from the Hynes lab (@APHage_) on probiotics, prophages and how they might interact! For the full story go see poster #42 and ask about her amazing work on Lacticaseibacillus! @CSM2023_Halifax #CSM_SCM2023 #CSM2023
0
3
13
When my 4-y old packs his lunch, it's by taking the easiest path to meeting our criteria for 'lunch'. With no consideration for the food he actually wants to eat that next day. There's a lesson there...
0
0
2