joe
@jtyler91
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Big dumb scientist. Biochemist/cell biologist
Joined March 2012
More outsourcing of critical thinking to chat bots that do not give any creative or actually inspiring feedback. True innovation will come to an end as people get more and more dependent on LLM to tell them what they want to hear.
BIG ANNOUNCEMENT📣: I haven’t been this excited to be part of something new in 15 years… Thrilled to reveal the passion project I’ve been working on for the past year and a half!🙀🥳 It started from my frustration with the depressing effect that the current publishing system has
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I'm thrilled to share that I will start as an Assistant Professor @Hunter_College @CUNY this Fall! We will investigate how chemical and mechanical signals modulate the cytoskeleton to drive cancer and immune cell migration. I'll be recruiting! DM or email at dhimanpal8@gmail.com
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New work out in @NatureComms! Thank you to my collaborators and editors! https://t.co/3FTyJJB3lr
nature.com
Nature Communications - Here the authors use synthetic tools to control elements of the cytoskeleton during amoeboid migration. They uncover two feedback loops sufficient to generate cell polarity;...
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📢 Pre-print alert 📢 We are excited to share the lab's first research article! We used our artificial cortex system to investigate how membrane composition regulates self-organized cortical dyanamics. Check it out here:
biorxiv.org
Cortical excitability, a phenomenon in which the cell cortex is dynamically patterned with waves of F-actin assembly, has been described in a variety of animal model systems, including embryos of...
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Joe Tyler @jtyler91, Anthony Davidson, Vassilis Koronakis & team find that inhibition of PAK activity leads to the production of PI(3,4,5)P3 at the plasma membrane & a dysregulation of the actin cytoskeleton. https://t.co/ThUGeYVSgF Article: https://t.co/hGeoNLrFLU
#OpenAccess
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Evaluating different deconvolution algorithms today. Behold the power of Richardson-Lucy!
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Actin waves + inverted LUTs 🤩 (bonus points if you can guess the cell type)
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Now online! Genetically encoded reporters of actin filament organization in living cells and tissues https://t.co/XQwlWMRLaV
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NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration. https://t.co/vBE93N8F2P
#biorxiv_cellbio
biorxiv.org
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating...
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A long-awaited mechanistic analysis of small GTPase biology and membrane pattern formation by the labs of Peter Bieling and Bill Bement @BementLab
https://t.co/E3FidcWRXj
embopress.org
imageimageFormation of Rho GTPase activity patterns on the plasma membrane is key to numerous morphogenic processes in eukaryotic cells. This study employs a reconstitution approach to reveal the...
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In my opinion, one purpose of poetry is to express something that can’t be described within our ‘normal’ manners of expression. This is something that Isn’t necessarily ’enjoyable’. Understanding is forged in contradiction… Reproduction of style is meaningless
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🚨Long term postdoc position available on the reconstitution of lipid kinases!🚨 Do you have a passion for protein reconstitution and lipid signalling? You will reconstitute lipid kinases to determine their kinetic regulation. https://t.co/C0iC2gJLDX
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Excited to share my first contribution to virology, 1 year into my postdoc @towerslab! Together with my colleague @kate_morling, we review latest advancements of how HIV capsid and accessory proteins Vpx/Vpr have evolved to regulate host innate immunity. https://t.co/TWwyFuk182
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Congratulation Mubarak (Kai Erdman's lab) on passing your PhD viva today!!!! 🎉 @ScienceShef @sheffielduni
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Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions
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Screen for novel kinase regulators by @Montse_Llanses @ERainero_lab &co shows that the α2β1 integrin/p38 signaling axis is needed for internalization of #integrin-bound #ECM, modulating cell migration & invasion in diverse #cancer cells #PLOSBiology
https://t.co/Sd8CfONGxe
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Great day at #actin2024 featuring lots of v cool talks, including our very own @rachellawson954, @ZheBao_Sheff and @jtyler91 ✨
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Please enjoy this movie of local #microtubule disassembly inside the yellow circle using #optokatanin (magenta) with ER labelled in cyan & please give me a follow on Bluesky! https://t.co/QcVDDbxYQa
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نور حب ماما وبابا غادرت متألمة، مثخنة بجراحها نحو السماء .. Noor, a young child from Gaza, was killed by an Israeli bombing. When they found her lifeless body, they saw the tender words she had written on her small hand: “Noor loves Mama and Baba”
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Nearly 70% of Gaza war dead are women and children, UN says
bbc.com
A UN agency verified victims from a six-month period and said it found international law violations.
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