Joyce
@joycejoy22
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PhD student at National University of Singapore
Joined August 2013
We compared 10 p-tau blood assays in our latest paper in @Brain1878! P-tau217 is consistently better than p-tau181, mass-spect (MS) assays are better than best immunoassays, with MS p-tau217 reaching very high accuracy (AUC<0.93)! https://t.co/tfc4lJxZKw
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Our most important clinical paper so far. In the @prevent_ad, 60% of our cognitively unimpaired participants with amyoid and tau PET binding developed MCI in ~2 years, a number that increased to 80% in those with hippocampal atrophy. The findings are replicated in 3 cohorts.
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New paper in @NatRevNeurol We present state-of-the-art review of recent developments in plasma phospho-tau: - Analytical methods 🩸 - Molecular interpretation 💉 - Clinical use 🩺 https://t.co/tTQzEPlSFa
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I am very pleased to (finally!!) share this paper co-authored with @andrealessa @pedrorosaneto in @eBioMedicine More evidence that #pTau231 changes very in #AD continuum – associated with subtle regional #Aβ deposition. #pTau217 shows ⬆️ fold-changes in symptomatic disease.
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We're ramping up recruitment for our multi domain lifestyle intervention study to prevent cognitive impairment and physical frailty!
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‘Untangling the relationship between microglia and tau in Alzheimer’s disease’ @TrendsNeuro ‘Spotlight’ by Samantha M. Rossano & William C. Kreisl https://t.co/AUVawOTdhw discussing Pascoal et al. @NatureMedicine, @TharickAPascoal @PedroRosaNeto
https://t.co/6AbLpRS9oG
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Plasma #GFAP detects #amyloid burden, independent of #Tau, differently to CSF GFAP and does it very early! A really fun and important collaboration! @andrealessa @Marta_Mila_ @VrillonAgathe @pedrorosaneto @M_SuarezCalvet @Imaging_AD @goteborgsuni @fpmaragall
It’s out!! Our study shows, with 3 cohorts, that plasma 🩸 GFAP indicates brain 🧠 amyloidosis, and it’s elevated already in preclinical AD. A great team work with @Marta_Mila_ @VrillonAgathe @NicholasAshton @pedrorosaneto @M_SuarezCalvet
https://t.co/ku23UmDvsc via @JAMANeuro
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👇Our latest work on synaptic biomarkers in #preclinical #Alzheimer, showing they increase in the earliest stages and differently associate with risk factors and neurodegeneration Thanks to @M_SuarezCalvet and all coauthors from @uniofgothenburg and @fpmaragall !!
"CSF synaptic biomarkers increase in early preclinical stages of the Alzheimer’s continuum even when a low burden of Aβ pathology is present"
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The BioFINDER team is proud to present the first large head-to-head study comparing different plasma Aβ assays. The study found that certain IP-MS methods clearly outperforms most other assays and should preferably be used in future studies and trials. https://t.co/F0J2AhIrYT
jamanetwork.com
This cross-sectional study compares the performance of plasma amyloid-β 42/40 (Aβ42/40) measured using 8 different Aβ assays and methods in detecting abnormal brain Aβ status in patients with early...
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The World Alzheimer Report launches tomorrow. Please join the webinar to hear about latest in diagnosing dementia. Very pleased to have contributed to the report with @andrealessa @TommyKakari as we focus on fluid biomarkers #WorldAlzDay 🩸🔬🥼
Our World Alzheimer Report, 'Journey through the diagnosis of dementia,' launches tomorrow 21 September, #WorldAlzDay. Join us as we look at the barriers & breakthroughs in #dementia diagnosis, as well as the future of diagnosis: https://t.co/tMDuSm1vdV
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It is hard to summarise the different technologies, advances and results in the explosion of #blood #biomarkers for #Alzheimers – but this does a pretty good job of doing so! Congratulations to @joycejoy22 et al, it was fun to work with you on this! https://t.co/oKF4fhB3tR
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Congratulations on emphasising the close links between brain health and heart health
In this study @AgingMacc @HilalSaima we showed the association of blood-based cardiac biomarkers (NT-proBNP, hs-cTnT, and GDF-15) with cognitive decline, incident cerebrovascular disease, vascular events and mortality over the follow-up of 3 years in a memory clinic population.
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From finger to singer : establishing a global evidence base for multiple lifestyle interventions
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AlzBiomarker v3.0 is live!! https://t.co/1aJjraWbL2 ✅case vs control update ✅multi-disorder ✅3700 cohorts & 238 meta-analyses ....all on #CSF & #plasma #biomarkers Fantastic to work with all @alzforum and, of course, Kaj Blennow & Henrik Zetterberg on this important project
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Pleased to share our multicenter study in >1400 persons across the #Alzheimer's disease spectrum, showing that #tau #PET is a promising #prognostic marker in #preclinical and #prodromal AD - outperforming #amyloid PET and #MRI, https://t.co/4Wok1MpwbF
@JAMANeuro @OskarHansson9
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Pereira et al. show that plasma Aβ42/40 is an independent predictor of future amyloid accumulation, whereas plasma P-tau217 is an independent predictor of tau accumulation, brain atrophy and cognitive decline. https://t.co/HISmPJSImX
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Well done @LutingPoh and @garriearumugam for showing that Intermittent Fasting attenuates the inflammatory response and cell death pathways in the brain following chronic hypoperfusion in a mouse model of vascular cognitive impairment (VCI). https://t.co/oxHXMdXWAa!
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Using advanced brain imaging techniques, Walsh et al. provide evidence of neuroinflammation and increased blood-brain barrier permeability in patients with cerebral small vessel disease. Both processes could serve as potential therapeutic targets. https://t.co/BipkrXG5dS
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Congrats to our PhD student Luting and close collaborator @garriearumugam for publishing: "AIM2 inflammasome mediates hallmark neuropathological alterations and cognitive impairment in a mouse model of vascular dementia" in Mol Psychiatry. Read here: https://t.co/zVlcfJGfit
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Congratulations to our SINGER team on our pilot study paper showing that multi lifestyle interventions are feasible and acceptable to Singaporean elderly https://t.co/UMYG2EE0TJ
pubmed.ncbi.nlm.nih.gov
This study is the first to compare the feasibility of multi-domain interventions adapted to local culture with the FINGER interventions. The findings will be utilized for a larger study to provide...
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