Poh Luting
@LutingPoh
Followers
5
Following
46
Media
0
Statuses
29
PhD student working on Vascular Dementia
Joined August 2020
Congrats @LutingPoh for an excellent review
Our latest review article provides a comprehensive insight into the molecular and cellular mechanisms involved in the pathogenesis of Chronic Cerebral Hypoperfusion (CCH)-induced inflammasome signaling in Vascular Cognitive Impairment (VCI). https://t.co/LjwTWEruCS
1
1
3
The capstone of @joycejoy22 PhD with @NUSMedicine is a great review not only of the recent advances in blood biomarkers for AD but also of the technology behind the high sensitivity. Everything you wanted to know about techniques but were afraid to ask!
0
3
8
Glad that together with @HilalSaima @CamStroke @ISD_Research @DondersInst et al, we have established the OPtimising mulTImodal MRI markers for trials of Vascular Cognitive Impairment due to cerebrAl small vesseL disease collaboration and its 1st paper https://t.co/RmusYf1nIy
pubmed.ncbi.nlm.nih.gov
Our results support a central role for WM alterations in dementia pathogenesis in all cohorts. DTI measures such as MD median may be a useful clinical risk predictor. The contribution of other MRI...
0
5
13
Another excellent paper from @LutingPoh and @garriearumugam on how hypoperfusion activates the inflammasome even in the cerebellum https://t.co/VNdOxTM7I8
pubmed.ncbi.nlm.nih.gov
Vascular dementia (VaD) is the second most common form of dementia and is caused by vascular pathologies resulting in chronic cerebral hypoperfusion (CCH)- induced brain injury, and ultimately...
0
2
4
Our Healthy Longevity programme featured by @NUSMedicine. Thanks for highlighting the SINGER multiple lifestyle intervention study! https://t.co/D0RHKFMLIF
medicine.nus.edu.sg
When I was younger, I thought the term “ageing gracefully” had a nice ring to it. I rather liked the idea of someone describing the 70-year-old me this way as I sipped chamomile tea and knitted a...
0
2
9
Congratulations on emphasising the close links between brain health and heart health
In this study @AgingMacc @HilalSaima we showed the association of blood-based cardiac biomarkers (NT-proBNP, hs-cTnT, and GDF-15) with cognitive decline, incident cerebrovascular disease, vascular events and mortality over the follow-up of 3 years in a memory clinic population.
0
2
2
So stunned by this incredible illustration of our work at the @ARUK_ODDI on NLRP3 inhibitors as Alzheimer's Disease drugs. Thank you to @JackBrougham for the illustration and the ECR funding awarded by @ARUKThamesV. #NLRP3 #DrugDiscovery @ARUKscientist #AlzheimersResearch #ECR
1
14
35
Excellent paper on how Sydenham was right to observe that we are as old as our arteries
Our new paper published in @GreenJournal examines the neuropathology correlates of aortic stiffening ( https://t.co/THZfdnOudv) - a necessary step in understanding how vascular disease affects the brain and #Alzheimers disease. Takeaways below. @VUMCNeurology @VandyAlz (1/8)
0
2
2
From finger to singer : establishing a global evidence base for multiple lifestyle interventions
1
3
12
Well done @LutingPoh and @garriearumugam for showing that Intermittent Fasting attenuates the inflammatory response and cell death pathways in the brain following chronic hypoperfusion in a mouse model of vascular cognitive impairment (VCI). https://t.co/oxHXMdXWAa!
1
6
15
Blood Phosphorylated Tau181, Neurofilament Light Chain, and Neurodegeneration in Alzheimer Disease
jamanetwork.com
This cohort study uses data from the Alzheimer’s Disease Neuroimaging Initiative study to investigate if blood-based biomarkers can be used to monitor the progression of Alzheimer disease neurodege...
0
12
15
I am very happy to be part of this excellent work published in Science Advances. Our data establish the influence of O-GlcNAcylation on Aβ accumulation and neurodegeneration, suggesting O-GlcNAcylation–based treatments as potential interventions for AD. https://t.co/C5itg4FQPr
0
6
7
Pushing the boundaries further
Clinical Relevance of Cortical Cerebral Microinfarcts on 1.5T Magnetic Resonance Imaging in the Late-Adult Population by @HilalSaima et al #MRI #stroke
https://t.co/xX6mEHuucT
0
3
7
congratulations to @YuekLing_Chai for her work on circulating osteopontin, a marker for inflammation, as a biomarker for cognitive impairment and dementia as well as MRI changes https://t.co/E9HwB30GqM
pubmed.ncbi.nlm.nih.gov
Cerebrovascular disease (CeVD) and neurodegenerative dementia such as Alzheimer's disease (AD) are frequently associated comorbidities in the elderly, sharing common risk factors and pathophysiolog...
2
2
5
Excellent first paper by masters student Mervyn Lim supervised by @HilalSaima on the effect of intracranial stenosis on executive function over time https://t.co/w2U3zYfYXf
pubmed.ncbi.nlm.nih.gov
Intracranial stenosis was independently associated with worse executive function across all time points, and cognitive decline in memory and visuomotor speed over 3 years of follow-up. This suggests...
0
3
3
Another important consequence of cortical cerebral microinfarcts which are associated with incidence and progression of geriatric neurobehavioral disturbances, independent of conventional SVD markers.
pubmed.ncbi.nlm.nih.gov
Cortical cerebral microinfarcts are associated with incidence and progression of geriatric neurobehavioral disturbances, independent of conventional small vessel disease markers. The impact of...
0
1
2
Great paper by @joycejoy22 with @NicholasAshton @TommyKakari and colleagues in Gothenburg on how useful blood biomarkers are in Asians with cognitive impairment and dementia https://t.co/lvghYMQoEf
pubmed.ncbi.nlm.nih.gov
Plasma P-tau181/Aβ42 ratio may be a noninvasive means of identifying AD with elevated brain amyloid in populations with concomitant CeVD.
1
6
20
Grateful to our Singaporean and regional colleagues, in particular the late and much missed simeon marasigan, for conducting this clinical trial in post stroke cognitive impairment https://t.co/wsed8leVu6
pubmed.ncbi.nlm.nih.gov
Whilst MLC901 appears to be safe, there was no significant cognitive benefit from MLC901 in the study population. Post hoc hypotheses generating analyses suggest that VCIND patients with existing...
0
2
8
Please let us know what you think of the beta version of our new website https://t.co/Olj1gk4WS5
medicine.nus.edu.sg
The Memory, Ageing and Cognition Centre (MACC) was established in 2010. The MACC aims to investigate and provide novel insights into the risk factors and biomarkers for cognitive decline and dementia...
1
2
6