Andrea L. Benedet
@andrealessa
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Assistant Professor at University of Gothenburg 🇸🇪. PhD in Neuroscience at McGill University 🇨🇦 Working with Dementia: PET and fluid biomarkers.
Gothenburg, Sweden
Joined May 2009
1/2 Today is my graduation day. For obvious reasons the ceremony is virtual, which is a bit frustrating. But I’m happy I’m officially a PhD. It was not easy as everyone knows, but it’s pleasant when you work with amazing people. Thank you @pedrorosaneto for being a great mentor,
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🚨Just published in @NatureNeuro🚨 Led by @jpfsouza33, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to Alzheimer’s disease progression. 🔗
nature.com
Nature Neuroscience - Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to...
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In our new paper, we show that neuroinflammation in Alzheimer’s follows a two-wave pattern of harmful effects: 1️⃣ First wave: triggered by amyloid-β (Aβ) 2️⃣ Second wave: driven by widespread tau pathology 📄
alz-journals.onlinelibrary.wiley.com
INTRODUCTION Current literature presents conflicting results regarding the impact of neuroinflammation on Alzheimer's disease (AD)-related neurodegeneration. While some studies suggest that neuroin...
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Do p-tau217 levels rise without amyloid or tau aggregates? 🐻 In our Acta Neuropathologica paper, we show that 🩸 p-tau217 increases ~300% during bear hibernation, while hibernating hamsters also show ⬆️ p-tau but no changes in MTBR tau. https://t.co/8QgRj9hfR9
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The 2nd year of the LMIC Brain Bank Mentorship Program to support researchers in establishing brain banks is coming! 📅In-person training: April 13-17, 2026 in São Paulo, Brazil. ✈️Travel fellowships available! ⏳Deadline: Dec 15, 2025 Apply now👉
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New paper published today in @NatureAging! This one took some time but it's always a pleasure working hand in hand with @MontoliuGaya and the Gothenburg team. Thanks also to the McGill group for also collaborating with TRIAD data. A 🧵 below. #ENDALZ
🚨New publication in @NatureAging🚨 Co-led between @MontoliuGaya and @gesalbla. We measured several tau peptides in blood and assess their different relationships with Alzheimer’s disease stages. https://t.co/L3ieR6wLrz 🧵
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I’m proud to share our systematic review & meta-analysis of plasma p-tau diagnostic accuracy studies :) https://t.co/zXOs1Yu6uF Some highlights:
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🇧🇷🧠 A força da ciência brasileira em peso no #AAIC2025! Mais de 100 clínicos e pesquisadores reunidos mostrando o impacto do Brasil na luta contra as #demências. Orgulho, conhecimento e colaboração transbordando! 💪✨ @ISTAART @CaramelliPaulo @zimmerlab1
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Thrilled to share that I’ve received my very first research grant! It will support my PhD project on developing fluid biomarkers.🧠🩸Huge thanks to my incredible supervisors @andrealessa @NicholasAshton @erzimmer
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Fluid biomarker discovery in Alzheimer's and neurodegenerative diseases using Nucleic Acid Linked Immuno-Sandwich Assay @AlamarBio @andrealessa
https://t.co/PZTKwEjqyW
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I’m proud to share the first PhD paper of my first (formally) PhD student Ilaria Pola, where we investigated proteins associated with TSPO PET imaging. 🥳 We are now already working on the extension of this work, so stay tuned! 🧠💧🩸 @NicholasAshton @mcgillu
New paper out! We explored immune-related proteins in CSF and plasma in Alzheimer's disease, linking TSPO PET to neuroinflammation. Highlights: CXCL1 and TNFRSF11B in CSF show strong links to TSPO and AD pathways. Check it out!
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Scientists use tau pathology markers in plasma and CSF to stage #alzheimersdisease. This could help identify and monitor people who might benefit from therapy. @goteborgsuni @mcgillu @lunduniversity @wustl
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Big thanks to the whole team at @goteborgsuni and @mcgillu!
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It's out! Our study evaluated early, intermediate and late AD pathology biomarkers and their relationship between CSF 💧and plasma 🩸across the AD "progression". Can these quantifications be used interchangeably between fluid matrices? Check it out 😉 https://t.co/vQbYejchL6
link.springer.com
Acta Neuropathologica - Recently, conceptual systems for the in vivo staging of Alzheimer’s disease (AD) using fluid biomarkers have been suggested. Thus, it is important to assess whether...
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The incredible @andrealessa! Congratulations—your work has inspired me, Brazilians, and people around the world! 🌎
I am very honored to have my work recognized by the AAIC Neuroscience Next! Thank you to all my mentors, colleagues, and friends who have been incredibly supportive along the way. @alzassociation
@goteborgsuni
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I am very honored to have my work recognized by the AAIC Neuroscience Next! Thank you to all my mentors, colleagues, and friends who have been incredibly supportive along the way. @alzassociation
@goteborgsuni
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and now the paper is out... https://t.co/8cXZYHjcoI 📣 33 different ways to measure #blood #pTau 👉Mass Spec, semi & fully-auto immunoassays 🩸#pTau217 consistently best 📈Corr. between #pTau217 assays = optimism for standardisation @jmschott @AshviniKeshavan @wagnersbrum
pubmed.ncbi.nlm.nih.gov
Paired plasma and cerebrospinal fluid (CSF) samples from twenty-five Alzheimer's disease (AD) and 15 non-AD patients were measured blind. Thirty-three plasma assays were compared, for phosphorylated...
🚨 Available as a preprint – The @alzassociation #pTau round robin study 🚨 📣 33 different ways to measure #blood #pTau 📣 Mass Spec, semi & fully-auto immunoassays 📣 #pTau217 consistently best 📣 Corr. between assays = optimism for standardisation https://t.co/ixEOOBXtT6
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📢 Publication alert 👉🩸 Thrilled to share our latest findings from the #DROPAD project on using capillary finger #blood for the detection of #progranulin that can identify mutation carriers in FTD! #Biomarkers #DROPAD
https://t.co/3RMGBrY3WM
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🚨 Available as a preprint 📝 The Impact of Kidney Function on Alzheimer’s Disease Blood Biomarkers: Implications for Predicting Amyloid-β Positivity 🧠 🩸 🤝 @MCSA_Montreal
@goteborgsuni
https://t.co/ej1kAHbuke
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🚨 Available as a preprint – The @alzassociation #pTau round robin study 🚨 📣 33 different ways to measure #blood #pTau 📣 Mass Spec, semi & fully-auto immunoassays 📣 #pTau217 consistently best 📣 Corr. between assays = optimism for standardisation https://t.co/ixEOOBXtT6
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Showcasing the new data from @AlamarBio
@andrealessa @JoelSimren @goteborgsuni @lunduniversity @OskarHansson9 @Imaging_AD
https://t.co/KsLfRmWaWW
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