Joon An
@joonomics
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Scientist working on autism genetics. Associate Prof at Korea University. family π¨βπ©βπ§βπ¦, swimming ππΌββοΈ but hiking too β°
Seoul, Republic of Korea
Joined January 2013
Dangerous gain-of-function research continues. Chinese virologists have constructed chimeras of bat SADSr-CoVs and SADS-CoV that show up to 10,000x enhancement of viral growth in brain. And have done so using grossly inadequate biosafety protections. https://t.co/YdoSttscIH
A new π¨π³ gain of function study created chimeric coronaviruses that can infect human cells and kill mice (up to 100% mortality). π©"The viral infection [and all animal experiments] were performed in a BSL-2 laboratory"(!)π€¦ββοΈ *The authors thank a.o. Ben Hu & Zheng-Li Shi.
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A massive Danish study of over 1 million children found ZERO link between aluminum in childhood vaccines and 50 health conditions β including autism, asthma, and autoimmune diseases. Real data. Real science. Vaccines remain safe. ππ
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An exome-wide association study of ADHD in 8,895 cases and 53,780 controls from the iPSYCH cohort published in Nature! Congrats to my former colleagues Jinjie Duan, Ditte Demontis, Anders BΓΈrglum and others. Demontis et al. Nature 2025 https://t.co/C1XLzwU7jY
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Thanks to the K-pop boom, we have tons of online sticker shops. Time for lab stickers!
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Proteoforms encoded by the same gene have different interactomes. This challenges: 1β£ The interpretation of data from reagents directed towards shared epitopes. 2β£ The assignment of functions to genes. When will biological research focus on such functional differences?
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Single-cell RNA sequencing shows gene activity in cells, and Nicheformer AI maps them back into tissue to reveal their spatial context and interactions. - @HelmholtzMunich - @TU_Muenchen
rna-seqblog.com
Nicheformer - a new foundation model that reveals how cells are organized in tissues
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Large-scale discovery of neural enhancers for cis-regulation therapies https://t.co/6Rn1VavsKe
#biorxiv_genomic
biorxiv.org
CRISPR-based gene activation (CRISPRa) has emerged as a promising therapeutic approach for neurodevelopmental disorders (NDD) caused by haploinsufficiency. However, scaling this cis -regulatory...
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Updated version of our preprint on how SETDB1-mediated H3K9me3 controls the expression of L1 elements in human neural progenitor cells. The new analysis in this revised version supports a role for active DNA demethylation of L1s in the absence of H3K9me3. https://t.co/q7pXxtcEjb
biorxiv.org
Heterochromatin is characterised by an inaccessibility to the transcriptional machinery and is associated with the histone mark H3K9me3. However, studying the functional consequences of heterochrom...
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Here I share the textbook "AI for Genomic Science" that I'm currently writing. It introduces fundamental AI concepts and computational methods using genomic applications, designed for senior-level biology undergraduates and graduate students. https://t.co/IO1N3XR81R
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Happy to share a free textbook for Human Genetics β Iβll be using this chaek (μ±
, meaning βbookβ in Korean) for my undergraduate course. With Dr. Jeongbin Park and several colleagues, weβre building a series of open-source textbooks across various topics. https://t.co/GPKxlGN3Sb
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β~7900 mothers βNo evidence of association between Tylenol and autism. It seems the larger the study, the less chance of seeing the association. That is a pretty good indicator that there is no real association... https://t.co/iehyIPEPOZ
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Tylenol, or paracetamol, has been used to treat common pains and fevers since 1893, and is one of the safest drugs around https://t.co/RNMosEDZyM
nature.com
Nature - Acetaminophen is one of the safest drugs around, but scientists still donβt know how it reduces pain and fever.
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