Richard H. Ebright
@R_H_Ebright
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Board of Governors Professor of Chemistry and Chemical Biology @RutgersU @BiosafetyNow
New Jersey, USA
Joined June 2009
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Postdoctoral Associate and Research Associate positions available in structural biology of transcription, transcription-translation coupling, and transcriptional regulation.
Cryo-EM and/or crystallography.
CV and cover letter to ebright
@waksman
.rutgers.edu.
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"NEWLY RELEASED documents provide details of US-funded research on..coronaviruses at the Wuhan Institute of Virology..The Intercept has obtained more than 900 pages of documents detailing..work of..EcoHealth Alliance..at the Chinese lab.."
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NIH corrects untruthful assertions by NIH Director Collins and NIAID Director Fauci that NIH had not funded gain-of-function research in Wuhan.
NIH states that EcoHealth Alliance violated Terms and Conditions of NIH grant AI110964.
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The documents make it clear that assertions by the NIH Director, Francis Collins, and the NIAID Director, Anthony Fauci, that the NIH did not support gain-of-function research or potential pandemic pathogen enhancement at WIV are untruthful.
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COVID: summary of lab-origin hypothesis:
1) Pandemic caused by a bat SARS-like coronavirus emerged in Wuhan--a city 1,000 miles from nearest wild bats with SARS-like coronaviruses, but that contains labs conducting world's largest research program on bat SARS-like coronaviruses.
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"Wuhan scientists were planning to release enhanced airborne coronaviruses into Chinese bat populations to inoculate them against diseases that could jump to humans, leaked grant proposals dating from 2018 show."
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"Wuhan Institute of Virology manipulated a coronavirus to generate..10,000 times the viral load, violating provisions of its NIH contract that forbade unregulated research that could make a disease significantly more dangerous or transmissible."
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The NIH received the relevant documents in 2018 and reviewed the documents in 2020 and again in 2021.
The NIH--specifically, Collins, Fauci, and Tabak--lied to Congress, lied to the press, and lied to the public. Knowingly. Willfully. Brazenly.
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The materials confirm the grants supported the construction--in Wuhan--of novel chimeric SARS-related coronaviruses that combined a spike gene from one coronavirus with genetic information from another coronavirus, and confirmed the resulting viruses could infect human cells.
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Senate Report, 10/27/22: "Based on the analysis of the publicly available information, it appears reasonable to conclude that the COVID-19 pandemic was, more likely than not, the result of a research-related incident."
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The materials show that the 2014 and 2019 NIH grants to EcoHealth with subcontracts to WIV funded gain-of-function research as defined in federal policies in effect in 2014-2017 and potential pandemic pathogen enhancement as defined in federal policies in effect in 2017-present.
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"The trove of documents includes two previously unpublished grant proposals that were funded by the NIAID, as well as project updates relating to the EcoHealth Alliance’s research, which has been scrutinized amid increased interest in the origins of the pandemic."
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The nine facts about the origin of SARS-CoV-2 that everyone needs to know are as follows:
1) SARS-CoV-2 is related to bat SARS-like coronaviruses from southern China and northern Laos.
2) SARS-CoV-2 entered humans in or near Wuhan in August-November 2019.
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The materials further reveal that the the grants also supported the construction--in Wuhan--of novel chimeric MERS-related coronaviruses that combined spike genes from one MERS-related coronavirus with genetic information from another MERS-related coronavirus.
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The materials further reveal for the first time that one of the resulting novel, laboratory-generated SARS-related coronaviruses--one not been previously disclosed publicly--was more pathogenic to humanized mice than the starting virus from which it was constructed...
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"Scientists in Wuhan working alongside the Chinese military were combining the world’s most deadly coronaviruses to create a new mutant virus just as the pandemic began."
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The materials reveal that the resulting novel, laboratory-generated SARS-related coronaviruses also could infect mice engineered to display human receptors on cells ("humanized mice").
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There were two funding cutouts between the NIH and the reckless coronavirus gain-of-function research at the Wuhan Institute of Virology: (1) Peter Daszak on NIH grant AI110864, and (2) Peter Hotez on NIH grant AI098775.
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COVID: summary of lab-origin hypothesis:
1) Pandemic caused by bat SARS-like coronavirus emerged in Wuhan--city 1,000 km from nearest wild bats with SARS-CoV-2-like coronaviruses, but that contains labs conducting world's largest research program on bat SARS-like coronaviruses.
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...and thus not only was reasonably anticipated to exhibit enhanced pathogenicity, but, indeed, was *demonstrated* to exhibit enhanced pathogenicity.
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(This had been evident previously from published research papers that credited the 2014 grant and from the publicly available summary of the 2019 grant. But this now can be stated definitively from progress reports of the 2014 grant and the full proposal of the 2017 grant.)
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"China began severely restricting the export of personal protective equipment (PPE), such as gowns and masks, months before notifying..world of..outbreak of Covid-19, it has emerged. PPE exports to the US fell by..50% between August and September of 2019"
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The 2020 "Proximal Origin" paper falsely claimed science showed COVID-19 did not have a lab origin. Newly released messages from the authors show they did not believe the conclusions of the paper and show the paper is the product of scientific fraud and scientific misconduct.…
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"They also planned to create chimeric viruses, genetically enhanced to infect humans more easily, and requested $14million from the [US] Defense Advanced Research Projects Agency (Darpa) to fund the work."
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10) In 2020-present, WIV and its funders/collaborators at EcoHealth Alliance have withheld information, misrepresented facts, and obstructed investigation...even though, if not connected to origin, they most easily could clear their name though cooperation with investigation.
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"Viscount Ridley..called for..investigation..in..House of Lords..'For more than a year I tried..to ask questions of..Daszak with no response. Now it turns out he..authored this vital piece of information about..work in Wuhan but refused to share it with the world. I am furious.'"
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2) In 2015-2017, scientists and science-policy specialists expressed concern that the Wuhan Institute of Virology (WIV) was conducting and contemplating research that posed an unacceptable risk of lab accident and pandemic (;
),
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"Darpa refused to fund the work, saying: 'It is clear that the proposed project led by Peter Daszak could have put local communities at risk', and warned..the team had not properly considered..dangers of enhancing..virus (gain of function research) or releasing a vaccine by air."
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"The bid was submitted by British zoologist Peter Daszak of EcoHealth Alliance, the US-based organisation, which has worked closely with the Wuhan Institute of Virology (WIV) researching bat coronaviruses. Team members included..Shi Zhengli, the WIV researcher dubbed 'bat woman'"
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COVID: summary of lab-origin hypothesis:
1) Pandemic caused by bat SARS-like coronavirus emerged in Wuhan--city 1000 km from nearest wild bats with SARS-CoV-2-like coronaviruses, but that contains labs conducting world's largest research program on bat SARS-like coronaviruses.
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See thread at:
How many times can one grantee violate the Terms and Conditions of one NIH grant without being penalized?
(Apparently, if the grantee is EcoHealth Alliance, the number is at least four.)
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COVID: updated summary of lab-origin hypothesis:
1) Pandemic caused by bat SARS-like coronavirus emerged in Wuhan--city 1000 km from wild bats with SARS-CoV-2-like coronaviruses, but that contains labs conducting world's largest research program on bat SARS-like coronaviruses.
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"The Covid-19 pandemic that has killed millions worldwide 'was most likely the result of a research-related incident' in China, and not natural transmission of a virus from animal to human, ..a new report by..Senate health committee concludes."
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Fauci committed perjury when he testified to Congress that the NIH had not funded gain-of-function research in Wuhan.
Fauci now has been referred to Attorney General Garland for prosecution for perjury.
An impartial Attorney General would prosecute.
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"[A]ccording to new reports this week three separate Chinese government officials have all named scientist Ben Hu, who was in charge of gain of function research at the Wuhan Institute of Virology, as the first human to be infected with the new disease."
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3) In 2017-2018, WIV constructed a novel chimeric SARS-like coronavirus that was able to infect and replicate in human airway cells and that had 10,000x enhanced viral growth and 4x enhanced lethality in mice engineered to display human receptors on cells.
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COVID: summary of lab-origin hypothesis:
1) Pandemic caused by bat SARS-like coronavirus emerged in Wuhan--city 1,000 km from nearest wild bats with SARS-CoV-2-like coronaviruses, but that contains labs conducting world's largest research program on bat SARS-like coronaviruses.
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8) SARS-CoV-2 is the only one of more than 100 known SARS-like coronaviruses that contains an FCS. This is a feature that does not rule out a natural origin, but that is more easily explained by a lab origin. Especially since insertion of FCS had been explicitly proposed in 2018.
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"Fauci likely caused the COVID-19 pandemic, by first opposing, and then repeatedly and flagrantly violating, US-government policies implemented in 2014 and 2017 to restrict gain-of-function research on potential pandemic pathogens"
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4) In 2018, in an NIH grant proposal, WIV and collaborators proposed to construct more novel chimeric SARS-like coronaviruses, targeting chimeras that replace natural spike gene with novel spike genes encoding spikes that have higher binding affinities to human cells.
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Fauci now has lied to Congress three times on the same subject.
Knowingly, willfully, and brazenly.
And, so far, with complete impunity.
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@NickytaLeb
We wait to see whether the Speaker of the House, who consistently has opposed and obstructed a House committee investigation with subpoena power, changes her position.
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9) The FCS of SARS-CoV-2 has codon usage unusual for bat SARS-related coronaviruses and has an 8-of-8 amino-acid-sequence identity to the FCS of human ENaCa. These are features that do not rule out a natural origin, but that are more--much more--easily explained by a lab origin.
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7) In 2019 a novel SARS-like coronavirus having a spike with high binding affinity for human cells, and having an FCS at the spike S1-S2 border--a virus having the properties set forth in the 2018 WIV NIH and DARPA grant proposals--emerges on the doorstep of WIV.
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@andyorange
Shared responsibility.
China (which recklessly performed high-risk research with inadequate safeguards) US (which funded, enabled, and encouraged the recklessness), and US officials and contractors (who violated US policies to fund the recklessness).
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5) Also in 2018, in a DARPA grant proposal, WIV and collaborators proposed to construct novel "consensus" bat SARS-like coronaviruses, and to insert furin cleavage site (FCS) sequences at the spike gene S1-S2 border of bat SARS-like coronaviruses,
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"Fauci had been informed by January 2020 that his institute had funded..discovery..dozens of novel coronaviruses at the Wuhan Institute of Virology, including the closest..virus to SARS-CoV-2, the virus that causes COVID-19, new records show."
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6) In 2017-2019, WIV constructed and characterized novel SARS-like coronaviruses at biosafety level 2, a biosafety level patently inadequate for work with enhanced potential pandemic pathogens and patently inadequate to contain a virus having transmission properties of SARS-CoV-2
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"The German government just placed an order for 10,000 mechanical ventilators. What’s the US government doing about a potential shortage here? Not much"
Ventilator Maker: We Can Ramp Up Production 5-Fold, But Haven't Been Asked
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@ScottGottliebMD
Failure to suppress will result in *complete* healthcare collapse, *complete* economic collapse, *complete* political collapse, *complete* geopolitical irrelevance, and *complete* chaos.
Choice is not bad vs. bad.
Choice is bad vs. catastrophic.
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"Newly unearthed documents reveal 'smoking gun' evidence that the COVID-19 pandemic leaked out of a Chinese laboratory from a synthetic coronavirus recipe engineered by American scientists"
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"What really went on inside the Wuhan lab weeks before Covid erupted?"
"Fresh evidence drawn from confidential files reveals Chinese scientists spliced together deadly pathogens shortly before the pandemic, the Sunday Times Insight team report"
"Scientists in Wuhan working alongside the Chinese military were combining the world’s most deadly coronaviruses to create a new mutant virus just as the pandemic began."
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Nicholas Wade: "In the three years or so since Covid-19 appeared, it has become increasingly clear, despite the protestations of virologists who do this kind of work, that the causative virus was probably the result of genetic manipulation in a lab."
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HHS letter to Wuhan Institute of Virology (WIV), 09/19/23: "NIH determined that..WIV conducted an experiment that violated the terms of the grant regarding viral activity, which possibly did lead..to..unacceptable outcomes"
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"Wuhan Institute of Virology had a 'serious biocontainment' incident' in 2019..according to a Senate report on COVID-19 origins"
"The 329-page report..states..the first death of COVID in China was in September 2019-two months earlier than first thought"
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No person has done more to damage trust in science than Fauci.
Fauci lies even when the facts are in full view and the lies are obvious.
He has no shame, and he has no decency.
Anthony Fauci very concerned about misinformation, still can't admit he promoted lots of misinformation.
Sociopaths never look inward, always project.
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"New documents obtained from a FOIA request revealed a 2018 grant proposal, written by American and Chinese scientists, to use...gain-of-function to...create a virus that can rapidly spread among people upon first contact."
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COVID-19: twelve arguments for lab origin:
1) Pandemic caused by bat SARS-like coronavirus emerged in Wuhan--a city that is 800 miles from wild bats with SARS-CoV-2-like coronaviruses, but that has labs conducting world's largest research program on bat SARS-like coronaviruses.
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@KanekoaTheGreat
"[I]f President Biden, by the stroke of a pen, would issue an executive order today to...reinstate Remain in Mexico,...that would stop the flow by 70%."
"One stroke of the pen by the President. He does not seem to care."
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At this point, there is sufficient evidence to conclude, beyond reasonable doubt, that SARS-CoV-2 entered humans through a lab accident.
This latest leak makes the case for a lab leak almost certain.
A reckless experiment, known at the time to be reckless, probably caused the death of millions of people.
Scientists and the media conspired to conceal the evidence.
Let that sink in.
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David Baltimore: "When I first saw the furin cleavage site in the viral sequence, with its arginine codons, I said to my wife it was the smoking gun for the origin of..virus..These features make a powerful challenge to..idea of a natural origin for SARS2"
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@NAChristakis
Anyone with a functioning brain could have predicted that indoctrinating students in identitarianism, racism, and ethnic division would exacerbate identitarianism, racism, and ethnic division.
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"Fauci emphatically denied that money went toward so-called 'gain of function' research..'That categorically was not done'"
Fauci lied to Congress again on Tuesday.
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"The health official who conspired with Anthony Fauci to downplay suggestions Covid-19 leaked from a Wuhan laboratory has revealed he lies awake at night agonising about the chain of events they set in motion."
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EcoHealth: "We will analyze all SARSr-CoV..sequences for..proteolytic cleavage sites in S2 and for..potential Furin cleavage sites..[W]e will introduce appropriate human-specific cleavage sites and evaluate growth potential in Vero cells and HAE cultures."
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How many times can one grantee violate the Terms and Conditions of one NIH grant without being penalized?
(Apparently, if the grantee is EcoHealth Alliance, the number is at least four.)
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"[T]he project is reasonably anticipated to yield a lab-generated monkeypox virus that is 1,000 times more lethal..than the monkeypox virus currently circulating in humans and that transmits as efficiently as the monkeypox virus currently circulating in humans."
"House Energy and Commerce Committee..today sent a letter to.. Lawrence Tabak,..[acting] director at the NIH, regarding details about a supercharged monkeypox experiment planned by an NIH researcher. "
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"Does it catch fraud..? No"
"Does it prevent..basic errors..? No"
"Does it stop..nonsense..from being published? No"
"Does it consistently chose papers worth publishing? No"
The Absurdity of Peer Review
What pandemic revealed about scientific publishing
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China has performed nearly 200,000 tests.
South Korea has performed nearly 28,000 tests.
Meanwhile, US--with most expensive, but most dysfunctional, healthcare system on planet--has performed just 414 tests and has little or no capacity to perform more ()
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10) A preponderance of evidence, including both the scientific evidence (facts 1-3) and the documentary evidence (facts 4-9), indicates that SARS-CoV-2 likely entered humans through a laboratory accident.
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Hotez reportedly is denying that his NIH grant supported the project by Shi of Wuhan Institute of Virology.
The denials are false:
(1) Funding from NIH grant AI098775 is acknowledged in a research publication by research team led by Shi Zhengli of WIV ()
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Kristian Andersen on the laboratory-accident hypothesis for the origin of COVID-19, 02/02/2020 (i.e., *after* writing the first draft of "Proximal Origins"):
"The main issue is that accidental escape is in fact highly likely–it's not some fringe theory."
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"American scientists planned to work with the Wuhan Institute of Virology to engineer novel coronaviruses with the features of SARS-CoV-2 the year before the virus emerged from that city, according to documents obtained by U.S. Right to Know."
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20 million killed. 25 trillion dollars lost.
Due--beyond reasonable doubt--to the actions of four researchers and research administrators who placed their egos and careers over the lives and interests of 7.9 billion: Zhengli Shi, Peter Daszak, Anthony Fauci, and Francis Collins.
"White House officials told The Telegraph the work did fall under gain-of-function rules and would have required review."
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"US taxpayers supported research in three Chinese labs that included risky gain-of-function experiments with coronaviruses at the Wuhan Institute of Virology, a new government report found Wednesday.
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...In other words, in the years before the start of the pandemic, the Wuhan Institute of Virology had taken most of the steps needed to convert a natural bat SARS-like coronavirus to a novel human pandemic pathogen having the properties of SARS-CoV-2.
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"The evidence that this virus probably came from the Wuhan Institute of Virology is now voluminous, detailed and strong."
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9) From the start of the pandemic, the Wuhan Institute of Virology and its collaborators have withheld information, misrepresented facts, and obstructed investigation...even though, if not connected to origin, they most easily could have cleared their names though cooperation.
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5) Wuhan has labs that, at the start of the pandemic, conducted the world's largest research program on bat SARS-like coronaviruses, possessed the world's largest collection of bat SARS-like coronaviruses, and possessed the world's only sample of a SARS-CoV-2-like coronavirus.
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...In other words, just a year before the start of the pandemic, the Wuhan Institute of Virology and its collaborators proposed to take the remaining steps needed to convert a natural bat SARS-like coronavirus to a novel human pandemic pathogen having the properties of SARS-CoV-2
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@JDiamond1
@ScienceInsider
@maggieNYT
Finally.
A federal appointee who has the honesty and courage to stand up to the brazen lies and shameless corruption of Trump's Covid-19 response.
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...or through a research accident (just as in the second third, fourth, and fifth entries of the original SARS coronavirus into humans, which occurred through a lab accident in Singapore in 2003, a lab accident in Taipei in 2003, and two separate lab accidents in Beijing in 2004)
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@Booker4KY
Why the surprise?
When offered a real candidate vs. the usual corporatist/militarist synthetic swill, rational voters will choose the real candidate.
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@pmarca
Fauci knowingly, willfully, and brazenly lied to Congress on at least three occasions.
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Sen Rand Paul to Fauci:
"The facts are clear: NIH did fund gain-of-function research in Wuhan…Your persistent denials…are…a stain on your reputation…Will you…finally take some responsibility for funding gain-of-function research in Wuhan?"
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Gain-of-function research on potential pandemic pathogens has no--zero--civilian applications. It is not needed for, and does not contribute to, development of vaccines or therapeutics. Its only applications are bioweapons-agents discovery, development, and characterization.
The single most important thing we can do to prevent a next laboratory-generated pandemic is to end gain-of-function research on potential pandemic pathogens
(the useless and reckless type of research that likely caused the COVID-19 pandemic).
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Fauci approved the reckless research that likely caused the COVID-19 pandemic that killed 20 million and cost $25 trillion.
Fauci flagrantly and repeatedly violated US-government policies to do so.
He needs to be held accountable.
Sen. Rand Paul: "[T]he virus came from the lab. But the lab only was able to function because the US funded it…Anthony Fauci approved…it…This is probably the worst decision ever made by a public health official in the history of time.'"
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"Peter Hotez..who has denounced a congressional investigation into gain-of-function research helped fund Wuhan Institute of Virology gain-of-function work"
Critic of probe into gain-of-function research helped fund Wuhan gain-of-function
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Cancel Everything.
Social distancing is the only way to stop the coronavirus. We must start immediately.
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All statements in all posts are demonstrable facts.
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"President Joe Biden missed a key deadline set by a bipartisan law he signed that called for the declassification and release of intelligence on the Wuhan lab and its possible links to the origins of COVID-19."
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Congress is finally investigating the lab accident covid-19 origin theory
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4) Wuhan is located 1,000 km from the nearest wild bats with SARS-CoV-2-like coronaviruses.
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@DrRobDavidson
Four individuals are responsible for--and need to be held accountable for--the lack of tests in US: President Trump, HHS Director Azar, CDC Director Redfield, and FDA Commissioner Hahn.
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