PROMISES MADE, PROMISES KEPT. Today, President Donald J. Trump met with freed Israeli Hostages: "You’re not a hostage anymore…today you’re HEROES."🎗️🇺🇸

Incredibly important data! Tradeoffs of PSA screening markedly improve with additional follow up @MoniqueRoobol @NEJM Nice editoral by @VickersBiostats https://t.co/oFYJJe4NCO https://t.co/ojWVGTYofK

ONE MESSAGE: RELEASE THE HOSTAGES NOW.

This study examines national trends in sedation use for prostate biopsies, identifying key predictors and analyzing insurance and patient costs. Insights may inform practice and policy decisions.

Exciting collaboration with @AlexandrePCheng @landau_lab @UltimaGenomics @nygenome @WeillCornell : ppmSeq, a dual-strand ultra-low error whole-genome sequencing(WGS) technology. We applied it to tumor-uninformed WGS ctDNA from patients with urothelial cancer by focusing on the

Data from a recent study showed that 1 in 6 men with GG1 prostate cancer ultimately had higher-risk disease when other clinical features were considered, indicating that biopsy grade alone may underestimate disease risk. @BashirAlHussein @jeshoag

After analyzing insurance claims from 172,148 prostate biopsies (2016–2021), we found that sedation rates increased from 16% to 25%. 📈 A history of prior biopsy, saturation code, and MRI guidance were the strongest predictors🚨 Full article: ⬇️ @CaseUrology @jeshoag

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature https://t.co/5c1mfZOrOR

Many men who survive cancer go on to become fathers; however, the effects of the treatment on sperm was unknown. @Shanypi1 @Camiloareg @jeshoag & team discover chemotherapy exposure is associated with an increase in new mutations in sperm of humans and mice:

The study utilized high-fidelity duplex sequencing on chemotherapy-exposed individuals and controls. Results showed a marked increase in sperm mutations among those treated with chemotherapy.

Our new paper in @JCI_insight reveals that chemotherapy significantly increases the somatic mutation burden in sperm, raising important considerations for male cancer survivors regarding fertility and potential risks to offspring.

@UHhospitals @jeshoag shares expertise with @WSJ on debate about former President Joe Biden's late-stage prostate cancer https://t.co/vANXyKImsk via @WSJ

So proud to see some of our work finally out! This project meant a lot to me—it taught me so much, from IRB navigation to international collaboration and translational science. Grateful for the mentorship of @jeshoag. Coming back soon! @CaseUrology

@UHhospitals @UH_RE_Institute @DanSimonMD recognizes Urology Institute faculty David Sheyn @randy_vincejr @drrpope @HijazAdonis @jeshoag @LPonsky at 2025 UH State of Research Address. Together with industry, government and an innovative clinical and research staff, they lead the

Happy to see our new paper out! A great collaboration with @jeshoag. We collected sequential sperm samples separated by decades, and used high-fidelity sequencing to measure germline mutation rates in individual men. https://t.co/jf9XkaKsZY

https://t.co/s1kxMVNXwE

Links to preprints of these other studies below https://t.co/s1kxMVNXwE https://t.co/q9HIZgBlU8

New paper from my group and @giladevrony’s! https://t.co/AGS3p55Qap Historically we measured new mutations in humans using trio studies (parents and offspring). This taught us that on average new mutations increase in offspring with paternal age. These trio studies showed

Out of press! 🚨 Prebx MRI use for PCa detection skyrocketed from 1.5% in 2012 to 30% in 2021—hitting 59% in men with prior bx! 📈 But access remains limited in rural areas. We also need clearer guidelines for bx-naïve patients!! @CaseUrology @jeshoag @JackMillot_