Gilad Evrony
@giladevrony
Followers
692
Following
1K
Media
13
Statuses
283
🧬🧠Center for Human Genetics & Genomics @nyulangone | @nyugrossman
New York, NY
Joined September 2013
RT @AlexandrePCheng: Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq)….
0
36
0
RT @TimCoorens: The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutatio….
nature.com
Nature - The Somatic Mosaicism across Human Tissues Network aims to create a reference catalogue of somatic mosaicism across different tissues and cells within individuals.
0
41
0
RT @genomeresearch: Call for Papers! @genomeresearch is now encouraging submissions for a Special Issue on The Genetics and Genomics of Som….
0
16
0
RT @nyugrossman: A new Ultra-Rapid droplet digital PCR developed by @giladevrony & @DanOrringerMD at @nyulangone may help surgeons detect c….
0
5
0
Congrats to first author Ben Harrison (Rockefeller), and also to Emma Mizrahi-Powell (NYU). See also the concurrent paper by Kuehl, et al. on this new syndrome:
0
0
0
Just published--a new Fanconi anemia syndrome caused by variants in FAAP100 (FANCX)--a wonderful collaboration between our NYU Undiagnosed Diseases Program, the Smogorzewska lab (Rockefeller; @MaintainGenome) and Bruce Gelb and Cassie Mintz (Mount Sinai).
2
2
18
Kudos to @Amoolya1199, @CaitLoh, and @meihliu from my lab for their years of work on this, and huge thanks to the research participants, our collaborators, and our funders.
1
0
3
Happy to see our new paper out! A great collaboration with @jeshoag. We collected sequential sperm samples separated by decades, and used high-fidelity sequencing to measure germline mutation rates in individual men.
nature.com
Nature Communications - Mutations accumulate with age in the male germline, and can lead to genetic diseases in offspring. Here, the authors collect from individuals sequential sperm samples...
New paper from my group and @giladevrony’s! . Historically we measured new mutations in humans using trio studies (parents and offspring). This taught us that on average new mutations increase in offspring with paternal age. These trio studies showed.
1
4
16
0
0
0
Our paper on Ultra-Rapid ddPCR (15 min tissue to result somatic mutation quantification) is now in @MedCellPress. A wonderful collaboration with @DanOrringerMD that succeeded because of the intrepid work of @ZacharyR_Murphy, Emilia Bianchini, and the team.
cell.com
Identifying a tumor’s molecular subtype during surgery and rapidly quantifying mutations in resected tissues intraoperatively could guide resection strategy and improve resections. Murphy, Bianchini,...
3
10
45
RT @waitbutwhy: Writing the Fermi Paradox chapter of the book and man that topic just never gets old. Double the length of my 2014 post an….
waitbutwhy.com
The Fermi Paradox: There should be 100,000 intelligent alien civilizations in our galaxy — so why haven't we found any of them?
0
529
0
RT @nyulangone: Excited to see NYU Langone Health researcher @giladevrony's recent @Nature study highlighted in @NIHDirector's latest blog….
0
7
0
RT @stergachislab: Thrilled to share the culmination of 4 years of #Fiberseq research enabling the accurate quantification of chromatin acc….
biorxiv.org
Most human cells contain two non-identical genomes, and differences in their regulation underlie human development and disease. We demonstrate that Fiber-seq Inferred Regulatory Elements (FIREs)...
0
22
0
We show some new findings since the pre-print, including APOBEC3A's ssDNA cytosine deamination pattern and detection of SBS1 precursor lesions. See our pre-print thread for more info: Congrats to co-authors and thanks to our funders!.
🧬 Preprint 🧬.Most mutations begin as a change in only one of the two DNA strands. To see these single-strand precursors of mutations, we developed single-molecule sequencing that achieves single-molecule and *single-strand* fidelity. . 🧵⬇️.1/11.
1
1
6
Now out @Nature, our paper on HiDEF-seq: single-molecule DNA sequencing that resolves single-strand changes (mismatches and damage)!
nature.com
Nature - A DNA sequencing method with single-molecule fidelity detects mismatches and damage present in only one of the two DNA strands with patterns that are both similar and distinct compared to...
18
58
228
We also combined Ultra-Rapid ddPCR with @DanOrringerMD's Ultra-Rapid stimulated Raman histology. Many thanks to all who contributed to this project and our funders. We hope Ultra-Rapid ddPCR enables new kinds of point-of-care diagnostics and molecularly-guided surgeries. 5/5.
1
0
1
We then brought Ultra-Rapid ddPCR into the operating room in brain tumor (glioma) surgeries, with measurements concordant with standard ddPCR. 4/5
1
0
0