Benchmarking of duplex sequencing approaches to reveal somatic mutation landscapes https://t.co/fjE6Ko34fe #biorxiv_genomic

Our Center for Human Genetics & Genomics at NYU is recruiting new faculty investigators:

Please consider submitting to the special issue in Genome Research on somatic mosaicism!

Deadline extended to November 1!

Highly accurate sequencing OR high throughput? We refuse to choose. Introducing paired plus-minus sequencing (ppmSeq), a method built to deliver both. Our latest paper with @UltimaGenomics 👀👀👀 See ⬇️ for a primer on the next frontier of genomics https://t.co/kl2KOaKziW

The cells in our bodies constantly acquire mutations. But what are the patterns of mutations across tissues? How do mutations in normal cells lead to disease? These and other questions we will tackle within the SMaHT Network, now described in @Nature https://t.co/5c1mfZOrOR

Call for Papers! @genomeresearch is now encouraging submissions for a Special Issue on The Genetics and Genomics of Somatic Mosaicism, Guest Edited by Drs. @giladevrony, @EAliceLee2, and @R_Rahbari.  https://t.co/jKuoADbJec #BOG25 #KSMosaicism25 #MITS25 #somaticmosaicism

A new Ultra-Rapid droplet digital PCR developed by @giladevrony & @DanOrringerMD at @nyulangone may help surgeons detect cancer cells in real time. Early results suggest it could make brain tumor removal safer and more precise. Watch: https://t.co/yydYIzW4CP ✍️ @MedCellPress

Congrats to first author Ben Harrison (Rockefeller), and also to Emma Mizrahi-Powell (NYU). See also the concurrent paper by Kuehl, et al. on this new syndrome:

Just published--a new Fanconi anemia syndrome caused by variants in FAAP100 (FANCX)--a wonderful collaboration between our NYU Undiagnosed Diseases Program, the Smogorzewska lab (Rockefeller; @MaintainGenome) and Bruce Gelb and Cassie Mintz (Mount Sinai). https://t.co/UyMKh8Hytq

See also two awesome recent sperm sequencing studies from @R_Rahbari and @aaronquinlan. https://t.co/7w22KrnjYt https://t.co/PaxWwB5uex

Kudos to @Amoolya1199, @CaitLoh, and @meihliu from my lab for their years of work on this, and huge thanks to the research participants, our collaborators, and our funders.

Happy to see our new paper out! A great collaboration with @jeshoag. We collected sequential sperm samples separated by decades, and used high-fidelity sequencing to measure germline mutation rates in individual men. https://t.co/jf9XkaKsZY

@MedCellPress @DanOrringerMD @ZacharyR_Murphy Non-paywalled link:

Our paper on Ultra-Rapid ddPCR (15 min tissue to result somatic mutation quantification) is now in @MedCellPress. A wonderful collaboration with @DanOrringerMD that succeeded because of the intrepid work of @ZacharyR_Murphy, Emilia Bianchini, and the team.

Writing the Fermi Paradox chapter of the book and man that topic just never gets old. Double the length of my 2014 post and updated with all the new ideas that have come out in the last decade. https://t.co/qq2G5IPYPk

Excited to see NYU Langone Health researcher @giladevrony's recent @Nature study highlighted in @NIHDirector's latest blog post! ⤵️

Thrilled to share the culmination of 4 years of #Fiberseq research enabling the accurate quantification of chromatin accessibility across the 6 Gbp diploid human genome with single-molecule and single-nucleotide precision. See thread for the main findings https://t.co/JEaTMohlxK

And here's a non-paywalled PDF link:

We show some new findings since the pre-print, including APOBEC3A's ssDNA cytosine deamination pattern and detection of SBS1 precursor lesions. See our pre-print thread for more info: https://t.co/6OwqHNRaey Congrats to co-authors and thanks to our funders!