Jerrin Thomas George
@jerrintgeorge
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Postdoc at Wiedenheft Lab 🥼 | Former HFSP postdoctoral fellow at Sternberg Lab| 🧬 CRISPR-Cas enthusiast | Interested in mobile genetic elements
Bozeman, MT
Joined November 2019
I am super excited to share our work uncovering the structure and mechanism of an ATPase-associated reverse transcriptase (RT) involved in prokaryotic antiviral defense, now available as a preprint on bioRxiv!🧬🦠🔬.🧵👇.
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RT @GraceKC: Can we use RNA to insert kilobases of DNA into the human genome, opening up a new way to engineer cells or treat disease?. Exc….
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RT @biorxiv_micrbio: Identifying phage proteins that activate the bacterial innate immune system #biorxiv_micrbio.
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RT @RafalMostowy: What determines who a phage can infect?. We tackled this question for temperate phages of Klebsiella — a bacterial pathog….
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RT @SantiagoFrangos: New cryo-EM structures shine light on key steps in CRISPR-based adaptive immunity!.Viral DNA induces a structural chan….
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RT @WenwenFang2: Excited to share our work on the structure of a natural RNA nanocage formed by the ROOL noncoding RNA, originally discover….
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RT @ScienceMagazine: "If my career has taught me anything, it’s that resilience alone doesn’t guarantee survival. But sometimes, it gives y….
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RT @fthoffmann: Excited to share my last major PhD work from the @SternbergLab. We discovered a mechanism that initiates transcription at p….
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RT @SternbergLab: The lightning (Cas12f-Sigma) does strike twice today.⚡️See below for a thread by our collaborators @LeifuChangLab describ….
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RT @kellogg_liz: Despite the chaos and turmoil, our lab is blessed to have 3 new postdoctoral fellow openings and we would welcome scientis….
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RT @stephentang23: Excited to share our newest paper, online today @Nature! We report the discovery of a highly unusual mechanism of antivi….
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RT @SternbergLab: Our latest story is now online @Nature! We discovered a phage defense system that deploys kilobase-long DNA homopolymers….
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RT @SternbergLab: Coverage of our collaboration with the Liu group. ' “This is crazy directed evolution!” - Makoto Saito'..
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Been eagerly awaiting this one—never expected 30% efficiency! 🤯 Incredible work, and huge congrats to all the authors from @SternbergLab and @davidrliu Labs!.
Today in @ScienceMagazine we report the development of a laboratory-evolved CRISPR-associated transposase (evoCAST) that supports therapeutically relevant levels of RNA-programmable gene insertion in human cells, a collaboration with @SternbergLab. 1/13.
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RT @BKleinstiver: In @nature we describe the use of scalable #proteinengineering & #machinelearning to predict millions of bespoke CRISPR-C….
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RT @omarabudayyeh: Inserting large, scarless DNA sequences is a major hurdle for gene therapy. We explored if site-specific retrotranspos….
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RT @ScienceMagazine: Bacteria may have adapted to oxygen well before Earth’s atmosphere was saturated with it, according to a new study in….
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RT @biorxiv_micrbio: Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery .
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RT @phagedirectory: .@liyuping927 (@UCSF) and colleagues published a new paper on a bacterial immune system targeting jumbo #phages, showin….
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I'm incredibly grateful to Blake Wiedenheft for being an amazing mentor throughout my time in his lab. Huge thanks to the @WiedenheftLab—Senuri, Murat, Quynh, Royce, Adelaide, Hannah, Ava and our newest faculty Steve—this work wouldn’t have been possible without your support,
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