Jonathan Henninger
@jehenninger
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Assistant Professor @CarnegieMellon | RNA-directed control of transcription and cell fate | Biomolecular condensates
Joined December 2014
Check out our review on an RNA-centric view of transcription and genome organization in an #RNA-focused issue of @MolecularCell! It was a delight to write with @youngricka. https://t.co/uxUeUa9705
cell.com
RNA molecules are involved in diverse regulatory mechanisms that contribute to gene activation, gene repression, and genome structure. Henninger and Young discuss how the more traditional DNA-prote...
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Final version of our L2G paper is now published at @TmlrOrg! Kudos to @WenduoC for leading this work. Paper:
openreview.net
Pre-trained language models have transformed the field of natural language processing (NLP), and their success has inspired efforts in genomics to develop domain-specific foundation models (FMs)....
Can we skip genomic Foundation Model pretraining? Our work L2G repurposes language LLMs for genomics via cross-modal transfer, matching fine-tuned genomic FMs. Kudos to @WenduoC & amazing collab w/ @atalwalkar. L2G, language to genome; L2G, life’s too good
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Happy to see this coming out at JCB!
Rongwei Zhao et al. @lab_zhang @CarnegieMellon show that, in #cancer cells using the alternative lengthening of telomeres (ALT) pathway, #SUMO levels at #telomeres influence the formation of ALT-associated PML bodies. https://t.co/AtBR771FBw
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Deadline coming up for this fantastic meeting!
The initial programme for our Genome Regulation Through #RNA conference has been released🙌 All remaining slots will be filled from talk submissions - register and submit by 04 September to be considered! 💸 Grants available to support attendance For application details & a
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Latest work on RNA condensation from the Banerjee lab, led by a superstar graduate student, Tharun Mahendran. Biomolecular condensates can enhance RNA percolation, leading to the emergence of multi-phasic RNA condensates. https://t.co/SyfgJfAvFf
nature.com
Nature Chemistry - Pathological aggregation of repeat-expanded RNA is implicated in neurodegeneration. Now results demonstrate that biomolecular condensates can promote irreversible clustering of...
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So fortunate to have Mike Rosen as the Keynote speaker at our 2nd Annual Steel City Condensate Symposium. The day was filled with great science from biologists, chemists, physicians, and computer scientists from CMU, Pitt & NYU. Condensates continue to surprise us in many ways!
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I am excited to share our review, published online today @NatRevMCB. Pilong Li, Gaofeng Pei, @Heankel_, and I review the current literature on the regulation of transcription by condensates, large length-scale assemblies of complexes (Figure 1). https://t.co/k5F3HElanv
nature.com
Nature Reviews Molecular Cell Biology - Transcriptional condensates, which are formed through dynamic multivalent interactions between proteins, RNA and chromatin, regulate transcription by...
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Our lab is very grateful for the support from the Kaufman Foundation & @PittsburghFdn! We are excited by the research that this support enables, studying fundamental roles for RNA molecules in regulating their own expression. https://t.co/hX21CnXDMg
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Pre-print alert! With experimental collaborators at the Young lab (MIT), we investigate how (i)active rRNA transcription maintains the size, spacing, and number of nucleolar fibrillar centers, (ii) the consequence of this arrangement on rRNA processing. https://t.co/Pm0FMqPp5G
biorxiv.org
Biomolecular condensates are membraneless compartments that organize biochemical processes in cells. In contrast to well-understood mechanisms describing how condensates form and dissolve, the...
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It was a pleasure working with @dhnisz and @HymanLab on this article for @NatureRevGenet where we review results from experimental and disease genetics that together provide insights into cellular functions and molecular specificity of condensates:
nature.com
Nature Reviews Genetics - Biomolecular condensates are membraneless cellular compartments that concentrate molecules such as proteins and nucleic acids. In this Review, the authors discuss how...
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The Department of Biological Sciences will host virtual information sessions about master's programs and Ph.D. program Oct. 28-Nov. 18. Learn more about the department and its programs: https://t.co/S9SvqWEL7G
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Genetic evidence for functional specificity in biomolecular condensates: https://t.co/aWxFqLLElb Free read only copy: https://t.co/eG3GF4lWlE
@bsabari
@idpsig
@HymanLab
@PappulabWashU
@Pha_Tran_Papers
@NatureRevGenet
@MPI_MolGen
#Condensates
#IDR
nature.com
Nature Reviews Genetics - Biomolecular condensates are membraneless cellular compartments that concentrate molecules such as proteins and nucleic acids. In this Review, the authors discuss how...
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Excited for 1st paper from our lab - led by the amazing @RyanKrue in collab. with @BrennerGroup1. How do we design intrinsically disordered proteins (IDPs) that lack a stable structure and are continuously shapeshifting for different target functions? https://t.co/OjIpmOGyZ1
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An RNA-centric view of transcription and genome organization. In this review for our #RNA focus issue, @jehenninger and @youngricka highlight the important roles of RNA in transcriptional regulation.
cell.com
RNA molecules are involved in diverse regulatory mechanisms that contribute to gene activation, gene repression, and genome structure. Henninger and Young discuss how the more traditional DNA-prote...
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Our latest work is now published in @MolecularCell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators.
cell.com
Gosztyla et al. identify the RNAs bound by zinc-finger proteins and demonstrate the roles of zinc-finger proteins in the RNA life cycle. They highlight two zinc-finger proteins of particular intere...
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Checkout the latest work from the lab online today in @MolecularCell where we find that distinct sequence features encoded in IDRs are responsible for targeting proteins to specific condensates. This work was led by @Nancybrillet @Prashan10011102 and @TvReshma .
Online Now: Disorder-mediated interactions target proteins to specific condensates https://t.co/yNMDWlDOLQ
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The Department of Biological Sciences is bringing quantitative biology to the forefront. https://t.co/jdsYumkzJi
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Excited to announce our latest publication from the amazing Ying Xie in @MolecularCell We find that stress granules and P-bodies fluidize the cytoplasm in response to diverse stresses. Tweetorial soon! https://t.co/p8c1uOZkqj
cell.com
Cells must reorganize when exposed to stress. Xie et al. discover that the cytoplasm is initially fluidized in all stress conditions they test. This biophysical change requires polysomes to disasse...
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Excited to share our latest work revealing tissue-specific downstream-of-gene (DoG) RNAs and TOPI's role in regulating DoG production published in @ScienceAdvances. Congratulations to first authors Kouki Abe and @maunze_brian!
science.org
DoG RNAs contribute to transcriptome diversity in human cancers.
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