Gene Yeo’s Lab at UC San Diego
@yeo_lab
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Gene Yeo's Lab: RNA regulation, technologies, disease models and therapeutics
La Jolla, CA
Joined May 2013
Our follow-up work on neuronal stress and aging is now online @biorxivpreprint! Led by postdoc @kevinrhine_, we found that double-stranded RNA activates the chronic stress response in aged neurons. Thanks to all of our collaborators at @UCSanDiego .
biorxiv.org
Neurodegenerative diseases are linked with dysregulation of the integrated stress response (ISR), which coordinates cellular homeostasis during and after stress events. Cellular stress can arise from...
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Congrats @KevinRhine_ and collaborators @UCSD @manorlaboratory, Eric Bennett, Rob Signer and John Ravits.
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These factors, such as ALS and AD linked TDP-43, mislocalize to the cytoplasm in aged neurons and leads to widespread splicing defects. Age-linked deterioration of RNA biology is a key driver of poor resiliency in aged neurons.
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I am excited to share UC San Diego's press release on our study that shows aged neurons are depleted of proteins that manage the transcriptome, particularly splicing factors.
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Our rapidly aging population poses the largest health challenge in our generation. Aging is a key determinant for neurodegenerative diseases such as Alzheimer's, ALS and Parkinson's, however the mechanisms underlying neuronal resilience in the context of aging are mostly unknown.
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Excited to share our story "Molecular Stress in Old Neurons Increases Susceptibility to Neurodegenerative Diseases"
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UC San Diego Ranks 9th in the World for Most Influential Researchers. Thankful to my previous and current lab members for the work and continued support for my making the cut again this year.
today.ucsd.edu
UC San Diego has the highest number of influential voices in the University of California system and tied for 9th highest among universities and institutes worldwide, according to Clarivate’s 2024...
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Grateful to UCSD for sharing our story "Key Pathway Leading to Neurodegeneration in Early Stages of ALS Identified"
today.ucsd.edu
Researchers at UC San Diego identify a key pathway leading to neurodegeneration in early stages of ALS, hinting at the potential for short-circuiting the progression of the fatal disease if diagnosed...
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Excited to share our paper showing that lowering SmD1 or inhibition of SMN complex leads to nuclear entry of CHMP7 a key protein in nuclear pore homeostasis. Expression of SmD1 reverse TDP-43 dysfunction in ALS patient-derived IPSC-motor neurons.
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Excited to be part of a new $12.7M Grant to Establish New CIRM-funded Center to Investigate Genetic Basis of Autism and Schizophrenia
today.ucsd.edu
Funded by a California Institute for Regenerative Medicine grant, researchers in the UC San Diego Verge Center aim to uncover the genetic mechanisms behind neuropsychiatric disorders.
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RT @MolecularCell: Online Now: Integrated multi-omics analysis of zinc-finger proteins uncovers roles in RNA regulation .
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🚨Excited to share another paper in @MolecularCell!🚨 In collab w/ @Columbia’s Marko Jonvanoic, Lena Street, & @HoustonMethodist’s Kris Brannan, we mapped RNA-aware, RBP-centric protein-protein interactions (PPIs) across the mRNA life cycle in human cells!.
cell.com
Street, Rothamel, Brannan, et al. generate an RNA-aware RBP protein-protein interactome across the mRNA life cycle in human cells, leading to the discovery of previously unknown RBP interactions and...
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@MolecularCell @MayaGosztyla Thank you to the labs of Eric Lecuyer, Daniel Dominguez, Marko Jovanovic, and @GraveleyLab for their important contributions to this work!.
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Our latest work is now published in @MolecularCell! We discovered new RNA-binding zinc finger proteins and demonstrated their functions in RNA splicing, stability, and polyadenylation. Congrats to 1st author @MayaGosztyla and our fantastic collaborators.
cell.com
Gosztyla et al. identify the RNAs bound by zinc-finger proteins and demonstrate the roles of zinc-finger proteins in the RNA life cycle. They highlight two zinc-finger proteins of particular intere...
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RT @ucsd_rna_center: 🚨 Reminder! 🚨 The registration deadline for the RNA & AI Symposium is just 2 weeks away! 🌟 Check out our impressive sp….
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🎙️ Check out the DASL Podcast , a platform dedicated to amplifying the voices of underrepresented trainees in academia! 🎙️ Tune in to hear the first 3 episodes filled with inspiring stories. Don’t miss out! #DASLPodcast #AmplifyVoices @czi @ucsddasl.
🎙️ Excited to introduce the DASL Podcast, a platform dedicated to amplifying the voices of underrepresented trainees at UCSD! We dive deep into stories of resilience, overcoming challenges, and navigating the complexities of academia. #DASLPodcast
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Excited to share our work in collaboration with @_KevinCorbett on detecting protein-RNA interactions with RNA-base editing in situ in fixed cells and primary tissues. Congratulations @Lisa_Liang13 and Tao in our lab! Thank you @czi for the support!
nature.com
Nature Communications - Retrieving interactions between RNA-binding proteins (RBPs) and RNA in endogenous biological contexts remains challenging. Here, the authors develop INSCRIBE (IN situ...
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Congratulations @MayaGosztyla and @Lisa_Liang13 on successful PhD defenses last and this monday! @MayaGosztyla has characterized the RNA binding activities of ~100 zinc finger proteins in cells, and @Lisa_Liang13 has developed in situ STAMP (INSCRIBE) stay tuned for their papers!.
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