Krishna Shrinivas
@shrinivaslab
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Asst. Prof of CBE at Northwestern @nu_chbe Scientist and engineer interested in how living cells work @shrinivaslab.bsky.social in the other place
Evanston, IL
Joined December 2008
Excited for 1st paper from our lab - led by the amazing @RyanKrue in collab. with @BrennerGroup1. How do we design intrinsically disordered proteins (IDPs) that lack a stable structure and are continuously shapeshifting for different target functions? .
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RT @LomvardasLab: Read this #preprint on @researchsquare: DNA sequence-induced solid phase transitions as a solution to the genome folding….
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RT @KalkiKukreja: Our paper on the role of cell division in early embryonic development is out online! Lot more co….
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RT @chrisfrank662: Finally, out in @ScienceMagazine today, our work on de novo protein design. Together with @HattoriLab , @sokrypton & @….
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I am super excited that my friend and collaborator @wilton_snead will be in the Chicago area soon. He is a thoughtful, careful scientist and a supportive mentor. Excited about all the amazing things from the future Snead lab & for more fun science-ing together :).
I am very excited to share that I'll be starting as an assistant professor in the Department of Cell & Developmental Biology at Northwestern (@NU_CDB) in 2025!.
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RT @LucksLab: Exciting time for #synbio education @NUSynBio! @shrinivaslab and I are revamping the intro to synbio course and incorporating….
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RT @biorxiv_biophys: Generalized design of sequence-ensemble-function relationships for intrinsically disordered proteins .
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RT @BiologyAIDaily: Generalized design of sequence-ensemble-function relationships for intrinsically disordered proteins. • The paper prese….
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Coarse-grained molecular simulations have emerged as good models of the sequence-ensemble map (Mpipi, Calvados, and more). So - we bridge ML & stat. physics to directly invert simulations to design IDP sequences with tailored ensemble functions incl. sensors, binders, and loops!
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In recent years, we have major advances for designing folded proteins (ref Nobel 2024 + Baker lab, AlphaFold, ColabFold etc.) that rely on accurate ways to map (and invert) sequence to a static structure. However, these don't apply to IDPs that occupy a huge structural ensemble.
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to….
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A thing every interdisciplinary scientist hears: "how is this X?" (X=physics, math, chemistry. ). Here is Hopfield's (thoughtful) perspective from his fabulous essay "Now What".
And the 2024 Nobel Prize in Physics does not go to physics. .
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An amazing and well-deserved recognition. Highlighting Hopfield's introspective meditations on the scientific path - an essay that I find deeply motivating and inspiring.
BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfield and Geoffrey E. Hinton “for foundational discoveries and inventions that enable machine learning with artificial neural networks.”
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RT @NobelPrize: BREAKING NEWS.The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Physics to John J. Hopfiel….
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RT @NobelPrize: BREAKING NEWS.The 2024 #NobelPrize in Physiology or Medicine has been awarded to Victor Ambros and Gary Ruvkun for the disc….
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RT @RosyCers: If you are an assistant professor whose group uses AI/ML for chemical or materials problems, join our slack! It's a way to as….
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RT @LindorffLarsen: Very nice article by @dmgerhard on . “The Dynamic Lives of Intrinsically Disordered Proteins”. with quotes from @G_T_He….
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RT @shrinivaslab: Come be a fellow at @NITMB_Chicago if you are interested in math, theory, or bio (or any combination)! . Great opportun….
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