Joe Chambers
@je_chambers
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Researcher @TheCIMR @Cambridge_Uni @MarciniakLab interested in cell biology, especially proteostasis and the ER. More active @joechambers.bsky.social
England, United Kingdom
Joined July 2017
Our paper is now out in @ScienceAdvances ! https://t.co/mX05lMhSR7 We found that the disease-causing “Z” mutant of α1-antitrypsin “gums-up” the endoplasmic reticulum (ER) by forming a solid matrix, shown here by hypotonic shock… 1/8
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I have a BBSRC CTP PhD on protein kinases & cancer therapies available to start in Oct 2025. It is a collaboration between my lab @BabrahamInst and @CR_Horizons @BabrahamUK We're a friendly bunch. We like cake. What's not to like? Please RT https://t.co/i7sG6gA5DL
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Our new paper is out, https://t.co/gsfDCeZHHX📄 on how a membrane-curving protein RTN4/Nogo links neurite regeneration and the tubular ER🕸️🧠 It's all about how it narrows tubules, slows luminal transport, restricting Ca2+ supply for the outgrowth puffs ☁️🧑🤝🧑@koslovergroup 🧵
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🚨With @AbellJonny & @Kosloverlab we are excited to organise “The Endoplasmic Reticulum Structure and Function Across Cell Types” session at #cellbio2024 #ASCBEMBO! If you are interested in ER, its cellular functions, send us your abstracts by Aug 6🔬 https://t.co/6eq3cyGlVZ
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Brilliant news! Congratulations Marina!
Congratulations to Marina for being awarded the Corday-Morgan #RSCPrizes for the development of unique probes and methodologies in fluorescence imaging! 🎉🔬
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Only two days left to apply to join my new lab at the University of Manchester @MCF_UoM @FBMH_UoM! #PleaseShare #Applynow
My lab @MCF_UoM is #hiring a Research Technician. I'm looking for someone with experience in #iPSC & #microscopy. You will be trained in #proteomics and the project will tackle the mechanisms underlying rare neurological diseases. Apply now! https://t.co/YIAYh70a85
#pleaseshare
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We're starting to recruit postdocs to work on this exciting ERC (now UKRI) project. Please get in touch if you would like to join us, or spread the word. #phosphatases #redox #Tcells @SFRR_Europe @ListerInstitute @EMBO_YIP
NEWS | Congratulations to Dr Hayley Sharpe @Sharpe_Lab @EMBO_YIP on the award of her @ERC_Research Consolidator grant to study the unsolved mystery of T cell signalling.
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Fantastic opportunity to work with a brilliant scientist using really innovative approaches. Apply!
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I am hiring a research assistant for my lab working on host-pathogen interactions of bacterial infections. Please send to anyone who might be interested. https://t.co/yyTQSd6QqK
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If you're interested in ER morphology and lysosome function in neurons then check our new BioRxiv paper out: Atlastin-1 regulates endosomal tubulation and lysosomal proteolysis in human cortical neurons
biorxiv.org
Mutation of the ATL1 gene is one of the most common causes of hereditary spastic paraplegia (HSP), a group of genetic neurodegenerative conditions characterised by distal axonal degeneration of the...
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Delighted our paper on oxygen tension in cell culture is now out in @embojournal. Particular congratulations to @joycelyntsi (see her🧵here). Thank you to our many collaborators, and to funders @wellcometrust @The_MRC @TheBHF 👇 https://t.co/mBTcGhwmYm
link.springer.com
The EMBO Journal - The in vitro oxygen microenvironment profoundly affects the capacity of cell cultures to model physiological and pathophysiological states. Cell culture is often considered to be...
Beyond excited to share my first paper from my PhD @DPhaz Lab @IMS_MRL now out in @embojournal! Special thanks to Sam from @TVPLab and @dougall_norris for co-leading this project with me. We found that many cell culture models, despite living in 18% oxygen, are hypoxic! 🧵below:
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Our📰 in PNAS now on how the ER shaped as nanoscopic pipework powers Ca2+ firing Explains why ER is shaped as a tubular network🕸️🔬and how ER defects cause neurodegeneration🧠? It’s all about Ca2+ Led by @CecileCrapart 👭👬@koslovergroup @AvezovL
https://t.co/mbM153ULCe 1/4
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Luminal transport through intact endoplasmic reticulum limits the magnitude of localized Ca2+ signals | now our in PNAS https://t.co/mbM153ULCe Additions include analysis of what happens to Ca2+ releases from sheets and ER misshaping effects on the Ca2+ releasing ip3 receptor
pnas.org
The endoplasmic reticulum (ER) forms an interconnected network of tubules stretching throughout the cell. Understanding how ER functionality relies...
Our new preprint on how the ER's structural integrity impacts localized Ca2+ signals: Changes in ER shape limit the efficient release of Ca2+ due to hindered luminal transport, Underscores the functional significance of the ER's normal architecture. https://t.co/XIZc5pJAns
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Come and work with an amazing scientist on amazing questions at the amazing @TheCIMR. It's a no-brainer! Apply!
🚨 JOB CALL!!! 🚨 If you’re interested in neuronal cell biology, come and work with us to use custom imaging and omics tools to study organelle contact sites in neurons. Please RT friends‼️ Open calls for a @wellcometrust funded Post doc and RA position listed below…
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If you're interested in doing a PhD, postdoc or looking for an RA position in Germany doing fun microscopy and cool immunobiophysics, have a look at my lab in Würzburg:
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Thrilled to see Jonny getting his lab up and running! Exciting times ahead, so keep your eyes peeled if you're in the market for PhD, postdoc or technician positions to do great science!
🍻🍻🍻Well folks…some great news to share. Incredibly happy to announce that I’ll be starting my group @TheCIMR in Feb2024 with funding from a @wellcometrust CDA. A massive thanks to CIMR and my various mentors @ProfKHarvey, @JLS_Lab, Craig Blackstone and Peter St George Hyslop!
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So incredibly excited to join @TheCIMR as a @wellcometrust funded CDA fellow. Cannot express my gratitude enough for the support from CIMR colleagues throughout the funding application. It’s an honour to be joining you!!
Delighted to be welcoming two new PIs to CIMR! Both Jonathon Nixon-Abell and @melissagammons1 are recipients of @wellcometrust Career Development Awards; we're looking forward to working with both https://t.co/rkyXkzXsIM
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We’re excited to share our work describing how formation of fluid assemblies called biomolecular condensates buffers intracellular water potential, published today @Nature. A thread: 1/9 [ https://t.co/ylQtbZ76MJ ]
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In a departure from biological rhythms, we’re excited to share our work describing the role of macromolecular assembly & condensation in the acute buffering of cellular water potential, published today @Nature. A thread: 1/16 https://t.co/4UPHq7vXZ3
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Incredible work from the @DeriveryLab, led by @_JosephWatson & @Lara_K_Kruger ! Summarised in this great thread.
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