Jose A Escudero
@jaegc
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Group Leader at Univ. Complutense (https://t.co/PvcZmyaDNe). Interested in #integrons, antimicrobial resistance and the molecular basis of adaptation.
Joined May 2011
RT @Laura_CorralesG: Tenemos un contrato disponible. Si estás interesad@ en la Biotecnología y la Microbiología, vente al @IBVF! @unisevill….
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RT @paula_micro: So happy to finally see our paper published! 🥂 . If you're interested in plasmid biology, check it out! 👀🧬.
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RT @VictorJCid: Comienza el #CongresoSEM2025 en #Jaen. ¡Todo por la Micro! @SEMicrobiologia @esmisionposible
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RT @UdcVet: 📢📢📢 Muchas felicidades a @jaegc y su equipo, compañeros/as de @VISAVET y del Dpto. Sanidad animal @VeterinariaUCM, por su recie….
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RT @ERC_Research: Today, a decision to increase ERC support for researchers moving to Europe was adopted. On top of normal grants, the E….
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This amazing work (and that from Landon Getz in @theMaxwellLab closes the circle and proves the critical role of integrons in bacterial defense. Enjoy the reading!!.
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Our paper is published back2back with one from @amazeld @CelineLoot and Eduardo Rocha, where @BaptisteDarracq & @EloiLittner show that Sedentary Chromosomal Integrons are biobanks of phage defense systems.
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An important aspect of our work is that the super successful "guilt by association" rationale does not work for Mobile Integrons, where most cassettes are AMR genes.
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They can also combine BRiCs with other BRiCs and AMR cassettes providing multi-phage/drug resistance. So the take home message is: Integrons are Mobile low-cost defense islands.
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The cost of BRiCs is variable and dependent on the genetic context, which can be very important in their spread. Additionally, Integrons can fiddle around with cassettes in the array to modulate the cost of defense systems.
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Now the science!! (no pun intended): we have found 47 phage defense systems among gene cassettes of unknown function (gcus). Most (43) of these Bacteriophage Resistance integron Cassettes (BRiCs) are novel, mobile, and many work in #ESKAPEE pathogens #phagetherapy ‼️
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Also, very grateful to our collaborators Dukas Jurenas.@pilardomingoc and @Tom_Jove,.and also to Jose R. Penadés for (very) helpful discussions.
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So happy and proud of all MBA-lab members that made it possible: kudos to @NicolasKieffe13 and @alberto_hca for leading the effort, and to Laura, Paula, Fran, Patri and @AndrePCarvalho for rowing together. What a team! (.
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With a bit of a lag for X. 🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 .Short 🧵 .
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