Jose A Escudero
@jaegc
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Group Leader at Univ. Complutense (https://t.co/PvcZmyaDNe). Interested in #integrons, antimicrobial resistance and the molecular basis of adaptation.
Joined May 2011
A 2 yr postdoc position at the Bacterial Genome Plasticity Unit of the Institut Pasteur (Paris) led by @amazeld in collaboration with Pierre-Alexandre Kaminski, funded by the French National Research Agency 👇
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A new encyclopedic review, for plasmid lovers: https://t.co/2ANVSvbeAX We (Mapi, Eduardo and I) hope you like it!
academic.oup.com
Abstract. Plasmids play key roles in the spreading of many traits, ranging from antibiotic resistance to varied secondary metabolism, from virulence to mut
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For MyD88 lovers... Out today! The first article out of Elba del Val's superb PhD thesis at @unicomplutense. A small step for one woman, a big step for our research on yeast-based SynBio models to understand human innate immune signaling pathways! https://t.co/PSALHrz9lH
link.springer.com
Cellular and Molecular Life Sciences - MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular...
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Nuestro compañero el Dr. Jerónimo Rodríguez Beltrán ha sido distinguido con el Premio Nacional de Investigación para Jóvenes «Margarita Salas» en Biología. Se le ha concedido por su destacada contribución en la investigación sobre resistencia a antibióticos. ¡Enhorabuena, Jero!
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Tenemos un contrato disponible. Si estás interesad@ en la Biotecnología y la Microbiología, vente al @IBVF! @unisevilla @cicCartuja
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🚨🚨New paper out!!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 https://t.co/PXcg5l8oNC
nature.com
Nature Communications - Plasmids exhibit a broad range of sizes and copies per cell, and these two parameters appear to be negatively correlated. Here, Ramiro-Martínez et al. analyse the copy...
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So happy to finally see our paper published! 🥂 If you're interested in plasmid biology, check it out! 👀🧬
🚨🚨New paper out!!! Come for the first large-scale analysis of plasmid copy number across species, stay for one of the most intriguing results of my lab: universal scaling laws in plasmid biology! 📈🧬 👉 https://t.co/PXcg5l8oNC
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📢📢📢 Muchas felicidades a @jaegc y su equipo, compañeros/as de @VISAVET y del Dpto. Sanidad animal @VeterinariaUCM, por su reciente publicación en @ScienceMagazine ✨️Aquí la reseña de @ucc_complutense sobre el hallazgo: https://t.co/XaHDGaDrvz
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@jaegc Como la nombremos una vez más ya serían 3... Y entonces se aparece!
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Today, a decision to increase ERC support for researchers moving to Europe was adopted. On top of normal grants, the ERC offers 'start-up' funding to help PIs establish laboratories/research teams in Europe. This extra is now x2 (up to €2 million!)
erc.europa.eu
The European Research Council (ERC) decision to increase its support for leading researchers moving to Europe has today been formally adopted. On top of its standard grants, the ERC offers additional...
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Next time, if you want the news without the lag, follow @jaescudero where the sky is blue
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This amazing work (and that from Landon Getz in @theMaxwellLab
https://t.co/yKYaQx496A) closes the circle and proves the critical role of integrons in bacterial defense. Enjoy the reading!!
nature.com
Nature Microbiology - Integrons are genetic elements that capture and store gene cassettes in Vibrio species. Bioinformatic and molecular techniques show that these regions can be hotspots of phage...
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Our paper is published back2back with one from @amazeld @CelineLoot and Eduardo Rocha, where @BaptisteDarracq & @EloiLittner show that Sedentary Chromosomal Integrons are biobanks of phage defense systems.
science.org
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes,...
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An important aspect of our work is that the super successful "guilt by association" rationale does not work for Mobile Integrons, where most cassettes are AMR genes.
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They can also combine BRiCs with other BRiCs and AMR cassettes providing multi-phage/drug resistance. So the take home message is: Integrons are Mobile low-cost defense islands.
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The cost of BRiCs is variable and dependent on the genetic context, which can be very important in their spread. Additionally, Integrons can fiddle around with cassettes in the array to modulate the cost of defense systems.
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Now the science!! (no pun intended): we have found 47 phage defense systems among gene cassettes of unknown function (gcus). Most (43) of these Bacteriophage Resistance integron Cassettes (BRiCs) are novel, mobile, and many work in #ESKAPEE pathogens #phagetherapy ‼️
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Also, very grateful to our collaborators Dukas Jurenas @pilardomingoc and @Tom_Jove, and also to Jose R. Penadés for (very) helpful discussions.
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