Karen Maxwell
@theMaxwellLab
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Phage biologist focused on virus-host interactions and bacterial pathogenesis.
Toronto, Ontario
Joined January 2016
It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS, indeterminate dendritic cell histiocytosis
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New paper with @theMaxwellLab : Phage reprogramming of Pseudomonas aeruginosa amino acid metabolism drives efficient phage replication https://t.co/XBDPHTpe6K
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There are people that submit their grants more than 8 minutes ahead of the deadline???
If you submit your grants last minute, you're in good company. Half of the applications were submitted in the last two days, in the 2005 NIH Pioneer grant cycle. The red bars indicate the awardees; one of them submitted just 8 minutes before the deadline.
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🚨New preprint from our lab! We map the RNA interactions in E. coli infected by lambda, revealing an RNA-driven regulatory layer in phage-host dynamics. We find a phage-encoded sRNA hijacking host replication machinery, impacting the phage cycle.#microbiology #phages @MeetingRna
Phage-encoded small RNA hijacks host replication machinery to support the phage lytic cycle https://t.co/b7RrzcsNWy
#biorxiv_micrbio
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We’re here at @WCHospital for the #GairdnerScienceWeek Women of Gairdner Event! High school students, researchers and local faculty are here with 2024 Canada Gairdner Award laureates Drs. Meghan Azad, Gagandeep Kang, and 2022 #GairdnerAwards winner Dr. Deborah Cook Watch the
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Please RT. 1x postdoc and 1xPhD position available in our group to study the role of NLR-like proteins in cellular development and antibiotic production in Streptomyces. Postdoc: https://t.co/1dxVBIizvm PhD position: https://t.co/W8DjdW3Brd Email me for more information.
biodtp.norwichresearchpark.ac.uk
SCHLIMPERT_J25DTP
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This was a wonderful meeting @SPP2330 again! Great kick-off of our second funding period! Amazing science going on in the phage field and great to see students/postdocs from the first funding period starting their independent labs. @dfg_public, @fz_juelich, @HHU_de
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Julia Frunzke @FrunzkeLab opening the annual @SPP2330 meeting! Looking forward to 3 exciting days of science! @dfg_public
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We are ready to go for the Annual SPP2330 Meeting on “New Concepts in Prokaryotic Virus-host Interactions”! With a fantastic line up of speakers: Alexander Harms @AHarms485, Karen Maxwell @theMaxwellLab, Samuel Kilcher @SamuelKilcher, and Mathias Middelboe @mmiddelboe1
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Rare opportunity to join my team, as the @PLOSBiology in-house editorial team is growing! It's a great team in a great journal, if I say so myself 😆 Please reach out if your have Qs & apply if interested!! UK or US; assoc or senior Please RT https://t.co/hzAuin4pRS
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A supervisor, postdoc and the new PhD candidate https://t.co/xUXtWJiI4M
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Congratulations to @UofT_dlsph postdoc fellow @michelle_olding on receiving the 2024 EPIC Career Transition Award to lead an independent project looking at the role of prescribed safer supply programs in improving access to HIV and HCV care! Read more: https://t.co/O0aqTCOyH3
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Anti-phage defence through inhibition of virion assembly @theMaxwellLab @pramalpatel
#phages #antiphage #prophages #phagedefence
#bacteria #microbiology #virology
https://t.co/GmDTGXTBKA
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This is definitely one of the longest running projects in the lab b/c we were stuck in a trap of thinking about Sie proteins blocking competing phages. But wasn't a satisfying answer to fit the biology we observed - kudos to @vee_coli for persevering and figuring it out!
New prepint alert @themaxwelllab! 📢 📢 📢 Superinfection exclusion (Sie) proteins aren’t just for defence – they also ensure the spread of viral progeny! Prophages that lack Sie proteins devour their young via a process we call the Kronos effect. https://t.co/uxv42rYPoJ
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New prepint alert @themaxwelllab! 📢 📢 📢 Superinfection exclusion (Sie) proteins aren’t just for defence – they also ensure the spread of viral progeny! Prophages that lack Sie proteins devour their young via a process we call the Kronos effect. https://t.co/uxv42rYPoJ
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I am thrilled to share our work on a novel prophage-encoded phage defence from @theMaxwellLab: Anti-phage defence through inhibition of virion assembly https://t.co/qgzR97s4KH
nature.com
Nature Communications - Bacteria have evolved various defence mechanisms to protect themselves against viral infection. Here, Patel et al. identify a type of antiviral defence that blocks virion...
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This old dude band’s cover of Tiffany’s “I think we’re alone now” https://t.co/b50UMTVmi4.year.
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Out today in @MolMicroEditors: Inhibition of PQS signaling by the Pf bacteriophage protein PfsE enhances viral replication in P aeruginosa https://t.co/TkZkgMeWer With our 🇨🇦 friends @DezielEric and @theMaxwellLab
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Congratulations to Gary Bader, Benjamin Blencowe, Timothy Hughes and Mikko Taipale on their chair appointments! 👏 The appointments will support research in disease biomarkers, gene regulation and host-pathogen interactions. #UofT Learn more 👉 https://t.co/v0ei69Y7Sw
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