Eloi Littner
@EloiLittner
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PhD candidate studying the evolution of integrons @epcrocha lab Microbial evolutionary genomics @institutpasteur @EPFL and @Polytechnique alumni
Joined June 2019
Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the @amazeld lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) https://t.co/OpWbGT45vp
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@RERC_SNCF UN SEUL train au-delà de SQY, et vous le mettez en train COURT ??? 🤣🤣🤣🤣 Vous le faites exprès je ne veux pas croire le contraire
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Our paper is published back2back with one from @amazeld @CelineLoot and Eduardo Rocha, where @BaptisteDarracq & @EloiLittner show that Sedentary Chromosomal Integrons are biobanks of phage defense systems.
science.org
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes,...
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With a bit of a lag for X... 🧪 Finally out after peer review, our work showing that "Mobile #Integrons carry Phage Defense Systems" is now published in Science 🎉 Short 🧵 https://t.co/afknW0ezz3
science.org
Integrons are bacterial genetic elements that capture, stockpile, and modulate the expression of genes encoded in integron cassettes. Mobile integrons (MIs) are borne on plasmids, acting as a vehicle...
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White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the @amazeld lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones.
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Again, many thanks to all the authors involved. Especially to the best co-first author @BaptisteDarracq, our supervisors @epcrocha, @CelineLoot, @amazeld, @FredoLeRoux, @BikardDavid, @AudeBer
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The thread of the preprint is available here, and the discussion also continues on the other blue platform!
Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the @amazeld lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) https://t.co/OpWbGT45vp
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White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the @amazeld lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones.
science.org
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes,...
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Excited to share our last collab paper, now out in print @ScienceMagazine!🎉 We reveal how dITP synthesis activates a SIR2 NADase effector to block phage infection! 🛡️🧬 https://t.co/pcBDNqW9zq
science.org
Signaling from pathogen sensing to effector activation is a fundamental principle of cellular immunity. Whereas cyclic (oligo)nucleotides have emerged as key signaling molecules, the existence of...
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Question for phage aficionados: We have some phages that are each interesting, e.g., because they target a novel receptor or are only distantly related to any other viruses. What would be a good journal to publish small papers with a basic characterization for each of them? 🤔🧬
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And here it is, the completed BASEL collection finally published as early access in @PLOSBiology - see the thread for more details. 🤗🧬🎣
🚨 🧬 Updated preprint on the completed BASEL collection - what's new? Some fun with bacterial immunity and a new P22 relative infecting E. coli K-12. A thread 🧵
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CURIOUS ABOUT PHAGE BIOLOGY!? CPIC lab at @Helmholtz_HZI is recruiting in the call +++ CURIOSITY IS INFECTIOUS +++ https://t.co/E5Y37LcLhv Did you spot the phage? Please share!
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Exciting times! Our latest preprint is now live 🤩! I truly believe this is one of the most significant contributions we've made. It offers fresh hypotheses about how pandemic Vibrio cholerae spreads globally. Let’s dive in!🧵..1/n https://t.co/1SfPNSzJsd
biorxiv.org
Our understanding of the factors underlying the evolutionary success of different lineages of pandemic Vibrio cholerae remains incomplete. Interestingly, two unique genetic signatures define the West...
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Emergency bulletin! 14 journals have co-published an urgent call for the deployment of microbial solutions against climate catastrophe, by @peixotors et al. https://t.co/yYQZO4Gm6b
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For the past two years, we have been working on a novel approach to identify origins of transfer by conjugation in plasmids from any bacterial species. We are thrilled to see this work now published in @NatureMicrobiol after thorough peer review! https://t.co/TpTxRy7jjd
nature.com
Nature Microbiology - Characterization of known plasmid oriT features facilitates identification of 21 oriT-containing sequence families which, alongside candidate sequence validation, expands our...
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Special kudos to the great @epcrocha and @NucciAmandine for their amazing support and contributions! For additional info, don't miss this thread on the work: https://t.co/nI048QckK3
New preprint alert! 🚨 Our latest work on plasmid mobility with @epcrocha & @NucciAmandine is now available. Identification of novel origins of transfer across bacterial plasmids. Read the full paper here: https://t.co/Ww8KuXyNZf Thread🧵below!
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Exciting news! I started the junior research group 'Complexes in Phage-infected Cells' at Helmholtz Centre for Infection research @Helmholtz_HZI looking forward to explore new jumbo phage biology. We’re hiring! Join us for a PhD position.
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OUT NOW 🦠 Prediction of strain level phage-host interactions across the Escherichia genus using only genomic information, by @AudeBer @hugovaysset @MDMlab_Paris @iame_center @PhagePasteur
https://t.co/76OT6aORBK
nature.com
Nature Microbiology - Phage–host interactions are computationally predicted using only genomic information, highlighting future research directions and enabling generation of custom phage...
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Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at @institutpasteur . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.
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Our IBEID S2I fellow Jorge Moura de Sousa from the lab of @epcrocha is now presenting the inter-host diversity and mobilization of #bacteriophages and their satellites. #science #genetics #infectiousdiseases
@doctor_jams @institutpasteur
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Why do #bacterial species' #TransformationRates vary so dramatically? @epcrocha @labXC &co show that #Legionella & #Acinetobacter transformation rates evolve by sudden changes, likely caused by conflicts between #MGEs and the host bacterium #PLOSBiology
https://t.co/odHj02Kjws
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