Loot Céline
@CelineLoot
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DR2-CNRS. Institut Pasteur Paris. Bacterial genome plasticity and evolution, antibiotic resistance and integrons.
Paris, France
Joined March 2021
A new history of integrons Thanks to: @amazeld @epcrocha @ParissiVincent @TNiault
@EgillRichard @BaptisteDarracq @EloiLittner @fredebibs @HubPasteur @BiomicsPasteur @GenGen_IP G. Millot, J. Cury, C. Vit, B. Néron, D. Lapaillerie.... https://t.co/gMkHdnIfg7
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White smoke, we have not only a new pope, but also 16 new anti-phage systems in integrons ! In collaboration with the @amazeld lab, we show in our new paper that cassettes of these large platforms encode known anti-phage defenses and uncovered 16 new ones.
science.org
Integrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes,...
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Félicitations à nos lauréats du Prix Agnes Ullmann ! @BaharogluZeynep explore l’impact des modifications de l’ARN sur la résistance aux antibiotiques. @ThomasRolland75 contribue dans le domaine la génomique des troubles neurodéveloppementaux. Bravo pour à eux pour ces travaux !
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Exciting update on this study - stop by on the blue side to learn more about it...
Buckle up for your Sunday read on the bacterial integron. Recombination sites come in many different shapes and their recombination efficiencies differ by 5 orders of mag?? Great study now on bioRxiv https://t.co/tdxgHIVOSU by Kate in collab with @CelineLoot and @amazeld 1/4
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Buckle up for your Sunday read on the bacterial integron. Recombination sites come in many different shapes and their recombination efficiencies differ by 5 orders of mag?? Great study now on bioRxiv https://t.co/tdxgHIVOSU by Kate in collab with @CelineLoot and @amazeld 1/4
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Finally out after peer review, our update on the integron model showing that translation rates of cassettes in first position influence the phenotypes conferred by others downstream. Great effort by @AndrePCarvalho
https://t.co/f0j1LreGOU
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Our last contribution to the technology arsenal for Vibrio cholerae by @KDebatisse @CelineLoot
bmcgenomics.biomedcentral.com
Background Vibrio cholerae O1 El Tor, the etiological agent responsible for the last cholera pandemic, has become a well-established model organism for which some genetic tools are available. While...
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Join us in Paris on April 8th-10th for the 2025 Symposium on the Immune System of Bacteria 🥖🍷🦠🧬. Excited to welcome these amazing speakers at @institutpasteur . Registration will open beginning of November. Abstract deadline February 28. Stay tuned.
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Finally out after peer review. The first SuperIntegron-less Vibrio cholerae... and it is virtually identical to the WT!
academic.oup.com
Abstract. Integrons are genetic elements that increase the evolvability of bacteria by capturing new genes and stockpiling them in arrays. Sedentary chromo
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1/ 🧵 Thrilled to share work of @EligoBio just published in @Nature ! We show proof of principle results of efficient base editing performed on E. coli directly in the mouse gut 🦠💡 #Microbiome #SyntheticBiology
https://t.co/efTztuluN9
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15 years after doing my PhD on integrons with @amazeld, I'm thrilled to see my old and new interests united with the exciting discovery of anti-phage genes in these fascinating genetic recombination systems.
Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the @amazeld lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) https://t.co/OpWbGT45vp
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Let's not underestimate Integrons this time. They can bring cassettes from Chromosomal Integrons in many genomes. And you know what? These are packed with defence systems too!!! Check the back-to-back work from @amazeld @CelineLoot @EloiLittner @epcrocha
biorxiv.org
Integrons are genetic systems that accelerate bacterial adaptation by acquiring and shuffling gene cassettes. Mobile integrons spread antibiotic resistance genes among bacteria, while the sedentary...
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Check out our latest preprint! This work was lead by @NicolasKieffe13 with the support of the whole MBA lab, especially @alberto_hca . If you are interested in the intersection between #Phage resistance and #AMR pull the thread! 🧵
biorxiv.org
Integrons are bacterial genetic elements that capture, stockpile and modulate the expression of genes encoded in integron cassettes. Mobile Integrons (MI) are borne on plasmids, acting as a vehicle...
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@MDMlab_Paris @BaptisteDarracq @epcrocha @CelineLoot @amazeld @FredoLeRoux @BikardDavid @AudeBer @weronika_slesak @KDebatisse Finally, have also a look at a related study led by @NicolasKieffe13 from @jaegc's group, released back-to-back https://t.co/biWCE69cio
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One of the cool advantages of working at @institutpasteur is having great microbiologists around. Many 🤯discussions on the theme of anti-phage systems and MGE in the last years with @epcrocha @dbikard @amazeld labs. Awesome review https://t.co/r3HEVh5W3I And now integrons 👇 !
cell.com
Bacteria deploy a broad range of defense systems to protect themselves against viruses and other mobile genetic elements. Here, we review recent work that reveals how most defense systems are carried...
Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the @amazeld lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) https://t.co/OpWbGT45vp
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Sedentary chromosomal integrons (SCIs) are biobanks of anti-phage defence systems! In a huge collaboration with the @amazeld lab, we showed that these flexible genetic platforms encode known defences and further discovered 16 new systems. A thread (1/n) https://t.co/OpWbGT45vp
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New preprint alert!🚀 Excited to share our latest preprint, where we discover a vast arsenal of phage anti-defense proteins using an interpretable machine-learning approach. Big thanks to @MartinPolz, @ShaulPollak, Mariusz Ferenc, and all collaborators! https://t.co/jqw0Z0EiDL
biorxiv.org
Antagonistic interactions with viruses are an important driver of the ecology and evolution of bacteria, and associating genetic signatures to these interactions is of fundamental importance to...
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https://t.co/eDtb7WocfM No more atypical, but still permissive! Kudos @KDebatisse Manuel, Philippe, Pascal and the rest of the Toulousains! even Antoine @Dupont9A 😉
onlinelibrary.wiley.com
While hundreds of mobile genetic elements utilising tyrosine recombinases (YRs) for integration and excision from bacterial genomes have been identified in databases, less than a dozen have been...
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It’s online! Follow up study from my main PhD project where we find how point mutation in the integrase and genomic rearrangements buffer the toxicity associated with cassette excision in the Superintegron in V. cholerae over just a few generations! https://t.co/F1kM9njQ6P
journals.plos.org
Author summary Bacteria have a great capacity to adapt to a wide range of stresses, such as the presence of antibiotics. The molecular mechanisms leading to this adaptation very often result in...
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The follow-up of our January Science advances paper! I am sure that you are all willing to know how survive the superintegron inversion? here it is , congrats @CelineLoot @EgillRichard
journals.plos.org
Author summary Bacteria have a great capacity to adapt to a wide range of stresses, such as the presence of antibiotics. The molecular mechanisms leading to this adaptation very often result in...
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I'm really outraged by the French govt's decision to cut almost €1 billion from the research and higher education budget. We're already far behind Germany, Austria, Belg., USA, etc. (2.22 vs 3.14, 3.26, 3.43, 3.46, etc. Wd Bk data) in terms of % of GDP devoted to research & dvpt
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