🚨Thrilled to share our latest work, published online today @Nature in which we decipher mechanisms underlying the enigmatic VEXAS syndrome - a huge team effort @MSKCancerCenter led by superstars @VarunNarendraMD + @das_tandrila 🧵1/ https://t.co/0ubLHCbR9I

We're excited to share that Dr. Omar Abdel-Wahab, a leukemia specialist at Memorial Sloan Kettering Cancer Center (MSK) and Chair of the Molecular Pharmacology Program at Sloan Kettering Institute (SKI), has been elected to the @theNAMedicine (NAM). NAM elects members each year

The 1st Annual Cincinnati Leukemia Research Retreat is off to a great start! We just finished Session 1 on Genetics, Gene Expressions and Functional Genomics.

Dr. Rubul Mout and a team in Dr. George Daley's lab at @HarvardMed designed Notch agonists that drive #Tcell differentiation. 📄: https://t.co/VvAR2LkTYQ 🎧: https://t.co/qb9GVwiipX

Our paper is now out in final form at Nature Genetics! For those who missed the preprint, we used large-scale Perturb-seq targeting transcription factors to push primary fibroblasts into diverse transcriptional states, including those observed in cell atlas studies.

Immune recovery after transplant may rely less on the thymus and more on choosing the right stem cells. A @NatureComms study with @DrMvandenBrink and @MelodySmithMD identifies a unique group of blood-forming stem cells—Kit(lo) HSCs—that significantly improve immune rebuilding

ICYMI: Putting AML Differentiation States on the BoneMarrowMap https://t.co/NvvSAh9sVL @livius_tacitus

The Man Who Never Got a Nobel, But Gave the World Methotrexate — A story of forgotten genius, cancer, arthritis, psoriasis… and hope. 💊💔🧬

Online Now! Non-canonical functions of DNMT3A in hematopoietic stem cells regulate telomerase activity and genome integrity https://t.co/Twl44S84Ps #stemcells

ASH Seeks Fundamental Discovery Science Abstracts for #ASH25 IF the quality is there, the fundamental basic science poster and presentations will E X P A N D at ASH25. Its an experiment! Submit your cool basic science before August 5, 2025, at 11:59 p.m.

Really valuable resource in @NatureCellBio from @Nina_CabezasW and team - Metabolomic and lipidomic profiling of human hematopoietic stem and progenitor cells: https://t.co/l22xKuXt7F

Excited to share our teamwork on spatially profiling human bone marrow trephines is now online! 🔬🗺️🦴 https://t.co/85kSWG6PTE More high-res atlases to come - liquid/solid cancer in bone, cellular therapies settings..💪 #Xenium #myeloma #spatialomics

From Nature Communications - Kitlo hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution https://t.co/e602CJwDqA #bwfpdep

@sunlab @sneha__mitra @MelodySmithMD @DeWolfSusan @AndrlovaHana @StatFei

Kit-low hematopoietic stem cells exhibit distinct lymphoid-primed chromatin landscapes that enhance thymic reconstitution @NatureComms @hrldelias @KharasLab @vandenBrinkLab https://t.co/6NN8HT1V1I

💬 14/ Let’s discuss! What are your thoughts on: 🧠 ZBTB1 as a therapeutic node? 🧬 KITlo HSCs as a regenerative tool? 🧓 Reversing immune aging or mitigating CH? We’re excited to explore this new HSC biology — join the convo below! 👇 🔚 End of thread

13b/ Special thanks: 🧫 @CrooksGay @juliagensheimer Kenneth Dorshkind 📊 Parashar Dhopala & Göran Karlsson 📝 Thanks to @NatureComms reviewers/editors for thoughtful feedback!

💡 Couthors: @sunlab @simongrassman Sneha Mitra, Christina Leslie

🧠 13/ ACKNOWLEDGMENTS Science is built in teams — across labs & institutions. Behind every discovery is a village of minds. Grateful for ours. 👥 Mentors: @DrMvandenBrink @KharasLab @cedunbar80 @Bhandoola_Lab 🏛️@MSKCC @CityofHope @NIH 🧪 Labs: @vandenBrinkLab @KharasLab

🎯 12/ TAKE-HOME MESSAGE Not all HSCs are created equal! KITlo HSCs = an elite, lymphoid-primed subset → Conserved, functional, and targetable across lifespan ZBTB1 = molecular driver behind their immune potential Big implications for aging, transplant, and CH.