Too happy to share my main 1st-author paper from my PhD, fruit of a fantastic collaboration with @AnaBoskovic18 🥳 Protein glycosylation is abundant in mouse embryonic nuclei after EGA, but its functional significance in vivo had never been tested 🧵1/8

Migrated! @sformich.bsky.social #Bluesky.

Thanks to the organizers of such a nice meeting bringing together different aspects of embryo development🔝& v happy to start meeting more scientists of the lively DevBio French community! #FromCellToOrganism2024.

Ps: super happy to apply for #MSCA and #EMBO postdoc fellowship, which without losing competitiveness admit candidates w first-author pre-prints 🌞 . because some little changes are happening already 🙃 let's speed them up!.

I am willing to put a lot of effort to evaluate my peers in the future, to give and improve this community. But let's start to make us feel more valued also from the top. Or more and more talented young scientists will leave academia (as already happening around me!).

This of course requires an application evaluation process that is a bit more time consuming i.e. actually reading more carefully the biorxiv instead of screening based on published/unpublished and where. But, other humble opinion, I think we deserve it.

Humble opinion of a fresh postdoc who loves waking up every day to do research: What should be valued is WHAT we achieved and HOW we achieved it, not HOW FAST and in which journal it ended up (v much depending on biology. which is unpredictable!).

Fundamental research, if courageous enough to take risks as I believe PhD works should be, can lead to many years of negative results. Mouse work takes time. Fresh DATA: 34% of EMBL PhD have 1 st author paper at the time of the defense.

I really believe my postdoc project - interdisciplinary and frontier-research - should deserve the possibility to get funding, as well I am v proud of the work of me, my fantastic supervisors and collaborators that led to the 2 publications under review.

Woo my LOI got selected for full application of #humanfrontierscienceprogram #postocfellowship (#HSFP ) Ah no wait, I cannot apply because my two papers under review since January are still not ACCEPTED FOR PUBLICATION. Is this OK? 1/7.

Ps: super happy to apply for #MSCA and #EMBO postdoc fellowship, which without losing competitiveness admit candidates w first-author pre-prints 🌞 . because some little changes are happening already 🙃 let's speed them up!.

I am willing to put a lot of effort to evaluate my peers in the future, to give and improve this community. But let's start to make us feel more valued also from the top. Or more and more talented young scientists will leave (as already happening around me!).

This of course requires a review process that is a bit more time consuming i.e. actually reading more carefully the biorxiv instead of screening based on published/unpublished and where. But, other humble opinion, I think we deserve it.

Humble opinions of a fresh postdoc who loves waking up every day to do research: .What should be valued is WHAT you achieved and HOW you achieved it, not HOW FAST and in which journal it ended up (v much depending on biology. which is unpredictable!).

Fundamental research, if corageous enough to take risks as I believe PhD works should be, can lead to many years of negative results. Mouse work takes time.

I really believe my postdoc project - interdisciplinary and frontier-research- should deserve the possibility to get funding, as well I am v proud of the work of me, my fantastic supervisors and collaborators that led to these 2 publications under review.

Back from a lovely weekend in beautiful Stockholm, where I had the chance to present my PhD findings at the "Epigenetic inheritance of disease" meeting in @karolinskainst & meet great scientists! Thanks to the organizers @QiaolinDeng @PerriLab Susana Lopes 😃

This project would have not been possible w/o the incredible gene editing facility of @EMBLRome, following our craziness to make 7 (!) mouse models🤠.

Ofc this is a first molecular characterization of these mice & again we leave many new open questions, but hopefully u find this useful & intriguing 🧐 8/9.

3. to reveal perturbation of silencing of transposable elements during embryonic development! TE reactivation upon O-GlcNAc perturbation had only been shown in vitro so far (10.1073/pnas.1912074117, 10.1101/2024.01.31.578097). 7/9.

. and in both Ogt-hypomorphic blastocysts and placentae, gene expression differences pointed to a slight developmental delay <-- this is what found much more clearly in the other paper! 6/9.