Hakim
@hakim034
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RT @SciencNews: Undruggable ‘disordered’ proteins become druggable with new AI techniques from David Baker. @ScienceMagazine . https://t.co….
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RT @WilsonLab2: Preprint from our collaboration with the labs of Gerry Wright and Shura Mankin @shuramankin identifying the first translat….
researchsquare.com
A significant challenge in addressing the antibiotic resistance crisis is identifying new antimicrobial compounds. Although natural products produced by fungi and bacteria, particularly actinomycet...
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RT @mdancho84: Understanding probability is essential in data science. In 4 minutes, I'll demolish your confusion. Let's go! https://t.c….
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RT @ScienceAdvances: A synthetic small molecule, C26, inhibits Salmonella pathogenicity by targeting the disease’s major secretion systems,….
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New research findings! .In a collaborative effort, we report sythetic small molecules that target HilD, the central regulator of Salmonella pathogenicity.
science.org
Synthetic molecules targeting HilD provide an antivirulence strategy to disrupt Salmonella enterica pathogenicity.
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Mitoxantrone targets both host and bacteria to overcome vancomycin resistance in Enterococcus faecalis | Science Advances
science.org
Mitoxantrone represents a promising dual bacterium- and host-targeted therapeutic for overcoming vancomycin resistance.
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Longer life is within reach. But keeping people healthy at 120+ is a whole new challenge. How many of today's rare diseases would peak in the 100-120 age range? How many unknown dysfunctions would emerge at 120-140. Extending life will reveal more challenges than anticipated.
Science is on the verge of eradicating aging as just another disease, bringing humans into a new era of prolonged health, where biological limits will be moldable at will. That's all.
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RT @CoE_CMFI: 🎥CMFI board member @lab_maier recently featured in documentary on bacteria. She and her lab members provide insights into th….
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We discovered new antibiotic resistance breakers. We report lasso peptides that target the histidine kinases VanS and VanSB in vancomycin-resistant enterococci and Staphylococcus aureus. Work done @Universite_Caen @CBSA_Lab. Collaboration with @Le_Museum @CNRS and @CermnUnicaen
Lasso peptides sviceucin and siamycin I have anti-virulence activity and restore vancomycin effectiveness in vancomycin-resistant . #biorxiv_micrbio.
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RT @JeremyFarrar: Blood culture-free ultra-rapid antimicrobial susceptibility testing
nature.com
Nature - An ultra-rapid antimicrobial susceptibility testing method is introduced that bypasses the need for traditional blood culture, demonstrating the potential to significantly reduce the...
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RT @T3SS2: Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity @sa….
biorxiv.org
The enteric pathogen Salmonella enterica serovar Typhimurium relies on the activity of effector proteins to invade, replicate, and disseminate into host epithelial cells and other tissues, thereby...
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Pleased to share our collaborative effort to develop anti-virulence agents. We unveiled a series of compounds targeting the transcriptional regulator HilD. Feedback is welcome!
Discovery of a synthetic small molecule targeting the central regulator of Salmonella pathogenicity #biorxiv_micrbio.
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RT @mark_blaskovich: Very interesting study (with link to overview) that shows that 86% of surgical site infections (spinal surgery) arise….
science.org
A study shows that surgical site infections in spine surgery often stem from the patient’s own microbiome, challenging current prevention strategies.
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RT @HelgeBode_Lab: Finally! After a long journey our latest NRPS engineering story is out at thanks to the hard wo….
science.org
Bioinformatic analysis reveals sequence sites ideal for engineering in enzymes that produce non-ribosomal peptide natural products.
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