Callie Glynn
@glynnca93
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Senior postdoc @RosFrankInst with @mcgrange. Structural biologist. Interests cryo-EM, cryoET, amyloid structure, tau, prion, iced tea. (She/her)
Oxford, England
Joined March 2014
RT @JasonSynaptic: Tau filaments are packaged in extracellular vesicles derived from human brains! Congrats @slfwlr . nice to see this fina….
nature.com
Nature Neuroscience - Using cryo-electron tomography (cryo-ET) and proteomics, this study identifies the tethering of pathological tau filaments within defined brain extracellular vesicles in...
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Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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RT @MathiasJucker: "Aged monkeys deposit impressive amounts of aberrant Aβ in the brain, but neither a multidomain dementia-like disorder n….
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RT @rgsheld: My latest bit of work is up as a pre-print. We made an AMPA receptor GluA2 knock-in mouse in order to label and localize endog….
biorxiv.org
Most synapses in the brain transmit information by the presynaptic release of vesicular glutamate, driving postsynaptic depolarization through AMPA-type glutamate receptors (AMPARs). The nanometer-...
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RT @ScienceMagazine: A 2022 Science study takes a close look at why the axolotl brain is so much more capable of regeneration than the mamm….
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RT @smead2: The structural line between prion and “prion-like”: Insights from prion protein and tau. A well written and thoughtful piece ab….
pmc.ncbi.nlm.nih.gov
The concept of ‘prion-like’ behavior has emerged in the study of diseases involving protein misfolding where fibrillar structures, called amyloids, self-propagate and induce disease in a fashion...
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Here @crying_EM and I demonstrate a method for obtaining sub-nanometer #teamtomo structural information from intact hippocampal slices with targeting accuracy into sublayers. No genetic modifications required, applications limited only to imagination.
After thousands of microscope hours and several years of painstaking optimisation, @glynnca93 and I are very excited to share our latest manuscript. We outline our approach to investigate the molecular organisation within hippocampus tissue using cryo-ET.
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RT @LabManka: Chronic Wasting Disease prion structure can no longer hide. Many congrats to Parvez Alam et al at Caughey Research Group | NI….
researchsquare.com
Chronic wasting disease (CWD) is a widely distributed prion disease of cervids with implications for wildlife conservation and also for human and livestock health. The structures of infectious prions...
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RT @SBGrid: New Title Alert: AreTomo3- a multi-GPU accelerated software package that enables real-time fully automated reconstruction of cr….
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RT @MichaelLinLab: Congrats to my friend and colleague Guosong Hong for his stunning and original discovery, published today in Science, on….
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RT @leonardojo: It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file….
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RT @WallaceUcsf: It’s incredible how densely packed the cell is with organelles and other structures! Just seeing a talk from JLS which b….
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RT @AndersSL: Really happy that our paper on solving the crystallographic phase problem using neural networks is out in @ScienceMagazine. T….
science.org
X-ray crystallography provides a distinctive view on the three-dimensional structure of crystals. To reconstruct the electron density map, the complex structure factors F=Fexpiϕ of a sufficiently...
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RT @CryoTUD: We previously showed that a coincident FM-FIB-SEM can be turned into a 4D-STEM system for in situ thickness determination (htt….
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RT @LabStahlberg: It is all a question of strain. This alpha-synuclein fibril "1B" causes Multiple System Atrophy (MSA) in mice. It resemb….
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RT @MichelGoed: V337M and R406W are the first known mutations in the microtubule-associated protein tau gene that give rise to filaments wi….
biorxiv.org
Frontotemporal dementia (FTD) and Alzheimer’s disease are the most common forms of early-onset dementia. Dominantly inherited mutations in MAPT , the microtubule-associated protein tau gene, cause...
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RT @eLife: Researchers present a platform for cardiac tissue cultivation with 3D ring-shaped cardiac tissues generated from human stem cell….
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RT @jpkreysing: @Beck_Laboratory @MPIbp FIB-lamellae benchmarking study by Maarten Tuijtel et al. now out in Science Advances! https://t.co….
science.org
Lamellae can be up to 180 nm thick without losing resolution when performing cryo–electron tomography with subtomogram averaging.
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RT @J0Ferreira: In our new #cryoFIB #cryoET preprint we imaged actin filaments in very fast moving Plasmodium falciparum sporozoites. We sh….
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RT @RosFrankInst: Registration is now OPEN for the Volume EM Technology Forum, taking place in October 2024. The three day conference will….
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