Szymon W. Manka
@LabManka
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Structural biology of prions @ImperialInfect views my own
London, UK
Joined June 2023
As ever, beautiful #cryoEM work from the lab of Hong Zhou with field-defining insights using #cryoET: “Kiss-shrink-run” unifies mechanisms for synaptic vesicle exocytosis and hyperfast recycling | Science https://t.co/7mQdMIRHgU
science.org
Synaptic vesicle (SV) exocytosis underpins neuronal communication, yet its nanoscale dynamics remain poorly understood owing to limitations in visualizing rapid events in situ. Here, we used optoge...
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MOSAIC lattice light sheet xy projection over 2+ hrs in human retinal pigment epithelial cells of endoplasmic reticulum remodeling (cyan) and transport of vesicles (yellow) containing β4-galactosyltransferase....
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We're hiring for a Head of Department to lead one of Europe’s largest and most impactful centres for infectious disease research — right here at @imperialcollege. We're looking for a strategic leader with vision and drive. Apply by 15 September👇 https://t.co/qTuQwPuTNy
imperial.ac.uk
Please note that job descriptions are not exhaustive, and you may be asked to take on additional duties that align with the key responsibilities ment...
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Please RT 🙏 If you’re an ECR working in the fields of structural or synthetic biology wishing to start your lab then come join us at Imperial, London. We’re looking to support outstanding individuals for external Career Development Awards/Fellowships https://t.co/Mw7aNCZle5
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🇺🇸 CHATGPT JUST GOT HANDS AND A CALENDAR Forget answering questions. GPT just learned how to do things. OpenAI’s new agent can now browse the web, click, scroll, shop, and even book your boat day in St. Tropez. It plans, compares, buys, and yes, it’ll build your group trip
“HUMANITY HAS PREVAILED (FOR NOW)” - CODER BEATS OPENAI IN WORLD FINALS A Polish programmer named “Psyho” just beat OpenAI’s model in a 10-hour coding showdown at the AtCoder World Finals in Tokyo. The challenge? Code the smartest way to guide a bunch of robots across a grid
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Our chapter focuses on MMP-3, a fascinating, pleiotropic enzyme that may even play a role in neurodegeneration, which is the focus of my current research. Much remains to be explored, as always...
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Pleased to see this chapter finally out - co-wrote it during the COVID lockdowns with my PhD advisor, now Emeritus Prof. Hideaki Nagase. The book took some time to come together, but it’s great to see it in print. https://t.co/CoSOJ3E7m1
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So glad to be invited to speak at the FASEB Protein Aggregation: Polymorphic Species conference - a real privilege to be among such thoughtful voices. Thank you for having me and I am looking forward to the conversations. https://t.co/jXDWWOD8jJ
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Recently out! An awesome commentary on our bacterial ESCRT-III work https://t.co/eUvfQT9jCu - big thanks to John McCullough and Wes Sundquist for this. And of course big shout out to #NSMB for the tasty cover!
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We developed a new siRNA drug candidate for prion disease, a @broadinstitute / @RTI_UMassChan collaboration. We now have an open IND meaning FDA has given us permission to start first-in-human trials. Work remains before trials can launch. The full update:
cureffi.org
FDA has cleared a new drug to advance to first-in-human studies in prion disease patients. Here's what this means.
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Apply by 18 May 2025!
mankalab.org
We are offering a PhD project focused on engineering fluorescently tagged prions in human cells
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12 lessons students learn in the Sinclair Lab: Lesson 1. Write the way you speak
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This may be the structural basis for interspecies transmission barriers, but it also suggests that these barriers are not absolute, and can be overcome.
In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! https://t.co/gfA1NXrjxA
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In this narrative review at @JNeurochem I propose that independent misfolding subdomains in PrP of different host species support prion diversity lacking any universally conserved conformational motifs across those species. Check it out! https://t.co/gfA1NXrjxA
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