Gavin Knott
@gavinjknott
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RNA Biochemist | Nucleic Acid Sensors | CRISPR | Lab Head @MonashBDI | Postdoc @doudna_lab | Ph.D. UWA. Views my own.
Melbourne, Victoria
Joined April 2017
Excited to share our new paper describing the structure of an SpCas9 adenosine base editor (ABE) out now @ScienceMagazine! Co-first authored with @Sarkele1, we captured a base-editor in the act using cryo-EM! (1/5).
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These are challenging targets, CRISPR which are large multi domain RNA binding proteins and ChuA - an uncharacterized transmembrane protein. End-to-end design and validation would not have been possible without the hard work of @CyntiaTaveneau @_danielfox and all co-authors!.
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We are excited to share pre-prints describing a successful foray into ML-driven protein design. With @Rhys__G we designed proteins to potently inhibit CRISPR-Cas13 ( or block heme piracy by pathogenic E. coli (:
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RT @PeterFineran: Did you enjoy @crispr2023 or want to come to the next one! The #crispr conference will be in @Christchurch_NZ organised….
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RT @luisarchaeota: Thrilled to share my remarkable journey visiting #MonashUniversity, #Melbourne. Blown away by the exceptional minds at t….
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RT @PeterFineran: Hi #CRISPR enthusiasts. #CRISPR2024 is being hosted in #NewZealand by @dsashital, @gavinjknott, @drbridgetwatson and I. I….
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An amazing opportunity to work with an incredible team on cutting-edge CRISPR research. Would highly recommend working with Audrey and her team at ASU!.
🚨We are hiring!🚨. The Lapinaite Lab is looking for a Postdoctoral Fellow #postdocposition with experience in #CryoEM. Join us and be part of an international team of researchers studying #CRISPR #baseediting #precisionmedicine #RNA. How to apply:.
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RT @NOTDRS_Monash: 📢Seminar alert!! Don’t miss the chance to hear all about life as an overseas post doc from a line up of fantastic speake….
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It’s been ~10 yrs since #CRISPR biotech exploded onto the scene. What’s new in the field and where is it headed? Join us in Berkeley for the 5th International Conference on CRISPR biotechnology to hear answers to these questions and more! More details -
aiche.org
CRISPR 2024 is an exclusive conference that unites leaders from industry, government agencies, and academia to discuss the latest advancements in genome editing technologies.
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RT @lulu_catapano: Coot 1 is out and it’s cooler than ever!🎉 #ccp4 .✅ the GUI has been re-implemented .✅ the graphics has significantly imp….
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RT @wilhelmstore: A-RNA Conference: Registrations open until April 1 and filling fast! The Inaugural Australasian RNA Biology and Biotechno….
a-rna.org
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RT @SnowMedical: Announcing our three new Snow Fellows!. Congratulations to Gavin Knott @gavinjknott @MonashUni, Emily Wong @em6wong @Victo….
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Thank you to @SnowMedical and the Snow family for this incredible opportunity. It’s an honour to be named a Snow Fellow and my team and I are thrilled to enable #RNA research. Also, a huge congratulations to the incredible @em6wong and @Stephintje who received Snow Fellowships!.
Our family is VERY proud to be supporting three more amazing researchers through @SnowMedical… bringing our commitment to medical science to over $90 million
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RT @tomrsnow: Our family is VERY proud to be supporting three more amazing researchers through @SnowMedical… bringing our commitment to med….
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RT @ScienceAU: Up next at #SciencemeetsParliament: Join Australia’s Chief Scientist Dr Cathy Foley @ScienceChiefAu to open our welcome rece….
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RT @mitchellrayoco1: Awesome opportunities to work at the University of Rochester, seeking multiple tenure-track faculty using a cohort rec….
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RT @MonashBDI: Building #mRNA therapeutics & #vaccine innovations in Victoria. Find out more about new grant funding opportunities to build….
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Ever wondered where Cas9 came from? @Sarkele1 and I wrote a 'First Cut' for @CRISPRjournal describing the epic work by @altaetran and colleagues on the origins of Cas9. Our summary: . The epic paper: . Phage be like👇
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Curious to know how the genome editor Cas9 unwinds DNA to "read" it? Check out this great story by @JoshCofsky from the @doudna_lab. When we saw the first cryo-EM maps Josh said: "WOW the DNA is like REALLY bent. This is what comes to mind when I'm thinking about the mechanism:"
New pre-print! While #CRISPR-Cas9 searches through the genome, how does it actually "read" DNA sequence information, which is normally hidden within the double helix? We determined structures of Cas9 in the act of DNA interrogation to find out! Thread below 👇 (1/8).
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Really cool stuff from @raphaeljlt and the team at @StanfordAILab - one step closer to understanding the code that defines higher order RNA structure! Check it out here:
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