Gargi Mishra
@garginotgarjee
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Intn’l MD-PhD Student at SUNY Upstate| AHA predoctoral fellow @AHA_Research| Powered by @mtholyoke| she/her
Joined April 2011
Can’t wait to hop on this in May 2028 😤 👏🏽
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“just look at the degree on that chick”
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As an MD/PhD, I'm probably biased here, but I find these oversimplified generalizations hard to understand. A quick look at any list of influential biomedical scientists (Nobel laureates, leaders across fields, big pharma CSOs, biotech founders) shows that MD/PhDs (or MDs deeply
The physician–scientist track (MD/PhD) in academic medical centers has become one of the great illusions of modern science - a path that promises to unite medicine and science but rarely fulfills either goal. Training stretches on for years as one person is expected to learn two
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imagine going on a hinge date for a lil dopamine and now you’re in your first lady era bc he actually became mayor
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How do dividing cells maintain mtDNA euploidy? Sharing new work by Sneha Rath that shows how the proton motive force (PMF) acts as a "puppeteer" to balance cell proliferation & mtDNA replication to maintain a stable mtDNA copy number.
biorxiv.org
Human mitochondrial DNA (mtDNA) encodes 13 essential components of the electron transport chain (ETC)[1][1]. A typical cell contains ∼1000s of copies of mtDNA, but how this copy number is stably...
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I fear the public will never truly realize the immense damage done to our scientific research system and its consequences. A loss of ~$4.5 billion in frozen or cancelled grants with at least 148 impacted clinical trials = 138,000 patients due to be enrolled or already enrolled.
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The Mitochondrial F-box protein 1 and DJ-1 homolog HSP31 support cellular proteostasis during mitochondrial protein import clogging https://t.co/MUuukXZg1L
#biorxiv_genetic
biorxiv.org
Mitochondrial biogenesis requires the import of ∼1,000-1,500 nuclear-encoded proteins across the Translocase of Outer Membrane (TOM) and the Translocase of Inner Membrane (TIM) 22 or 23 complexes....
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CRISPR came from yogurt bacteria. GLP-1s came from Gila monster venom. Taq polymerase came from hot spring bacteria. As much as we like to think that progress in biotech is driven by human design, our biggest breakthroughs over the years have all originated from nature.
The ocean is one of the last great frontiers of biology. More than 90% of all marine life (an estimated 2M species) have not been discovered. Also, only ~10% of the seafloor has been mapped at 100m resolution, "as compared to 100% of...Mars and Venus." We should sequence
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Today in @ScienceMagazine, we report a new DNA editing technology to seamlessly write massive changes into the right place in the human genome. The reason gene editing hasn't transformed human health is that current gene editing technologies like CRISPR are very limited. The
What if we could universally recombine, insert, delete, or invert any two pieces of DNA? In back-to-back @Nature papers, we report the discovery of bridge RNAs and 3 atomic structures of the first natural RNA-guided recombinase - a new mechanism for programmable genome design
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During my most recent pregnancy I got very sick with protracted high fevers. Tylenol was amazing. I counted down the minutes till I could take each dose. Causing fear over Tylenol use in pregnancy is so fundamentally evil as it causes women to fear essentially the only
🚨 RFK Jr. is about to drop a report linking Tylenol in pregnancy to autism. Sounds dramatic. But here’s the problem: the strongest science says otherwise. 📊 Sweden, 2.5M children. When you just look at population data, you see tiny risk bumps. But when you compare siblings
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bioRxiv has a dedicated section for negative results. Use it. Share negative results. Your colleagues will appreciate it.
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One major issue I have with encouraging students to “do research during med school” to earn a residency spot is that it cheapens what research actually is. It sends the message that research is something you squeeze in between learning physiology, primary care, surgery, and
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Once I… …finish med school …complete residency …become an attending …get that first paycheck after training …become partner THAT is when I’ll happy But then you aren’t. It’s called an Arrival Fallacy, and it impacts most physicians. It’s the idea that “once I get there
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🚨❗ Results of the FIRST EVER trial comparing ultra-processed food (UPF) and minimally-processed food (MPF) diets following healthy dietary guidelines on health (and the longest trial of UPF to date) published today in Nature Medicine What did we find? A Thread… 🧵 1/
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on my 26th birthday, i wrote I Took A Pill in Ibiza...11 years ago. The song became popular several years after i wrote it. This year I celebrated my 37th birthday. I feel proud to look at the song lyrics and know that NONE of them are true anymore. I've grown into a completely
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It is with heavy hearts that we share the passing of Dr. Samantha Garza. In honor of Sam's life, we invite you to donate in her memory to fund brain tumor research. Thank you to everyone who supported Sam throughout her battle. We love you forever, Sam. https://t.co/UY8r8g4MXD
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I never thought I’d live in a world where people were opposed to heating milk to 165F for 15 seconds to kill disease-causing microbes because some podcast bro told them so…yet here we are. Poor Louis. He must be rolling in his grave. 2/
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The solution isn't to ban AI. It's to use it strategically. The choice is yours: Build cognitive debt and become an AI dependent. Or build cognitive strength and become an AI multiplier. The first brain scan study of AI users just showed us the stakes. Choose wisely.
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In the category of "Not all heroes wear capes"... Dr. Peter Gates is an Australian neurologist who wrote the original 2005 paper on the Rule of 4s for localizing brainstem lesions. I first read this paper around 2012 while coaching med students. It was so helpful that I used it
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