Florian Grebien
@florian_grebien
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Cancer-Epi|Genetics|Genomics|Proteomics and Oncogenic Fusion Proteins @vetmedunivienna @StAnna_CCRI @CeMM_News
Vienna, Austria
Joined May 2009
🧬New strategy to fight #AML: A study led by @florian_grebien & team at @vetmedunivienna, @StAnna_CCRI & CeMM identified the protein SPOP as a direct regulator of the stability of NUP98 fusion oncoproteins, a potential target for new therapies. ➡️ https://t.co/9tLPqUw9XD 📄
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Dear all, We are starting an exciting project with @ClmentCarr5 in Paris, France. A fully funded PhD position is available in my group @VetmeduniVienna Please help us spreading the word! https://t.co/XSe1iMV3iA
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Check out a technology feature in @Nature by @ElieDolgin regarding our recent 'Killswitch' publication https://t.co/pSo1LYEDPn Thank you for the comments and first impressions @youngricka @IsaacAKlein @DanfengCai @SuperSciJew
@dhnisz @YZhang1997
nature.com
Nature - Synthetic peptide fixes biomolecular condensates, revealing how these enigmatic cell structures actually work.
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What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. https://t.co/Ds7i2wgCRT out now in @Nature with @henri_niskanen @dhnisz & team.
nature.com
Nature - Targeting a non-natural micropeptide ‘killswitch’ to several biomolecular condensates altered condensate compositions and revealed condensate functions in human cells
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Seruggia and Grebien labs @StAnna_CCRI all ready and geared up to #KindPhilipp2025 in Wilsede. Looking forward to 4 days of science with friends and colleagues 👩🏻🔬👨🏼🔬
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💡Research team finds CDK12 is a key vulnerability in AML with NUP98 fusions. New hope for targeted therapies in resistant childhood leukemia. Study by @VetmeduniVienna, St. Anna CCRI @florian_grebien & @CeMM_News in Nature Communications >>>
nature.com
Nature Communications - The epigenetic and transcriptional roles of Nucleoporin 98 (NUP98) fusion oncoproteins in driving pediatric acute myeloid leukemia (AML) remain to be explored. Here, the...
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🔬 New @NatureComms study by CeMM Adjunct PI @florian_grebien's team at CeMM, @VetmeduniVienna & @StAnna_CCRI uncovers how NUP98::KDM5A drives #AML via epigenetic rewiring—identifying CDK12 as a druggable target. ➡️ More: https://t.co/mDeGViMkxx ➡️ Paper: https://t.co/NUpKgyYH5D
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🔥New paper alert! Out now in @NatureComms: Using a novel model for targeted degradation of the NUP98::KDM5A fusion oncogene we show that CDK12 is an actionable vulnerability in AML. Proud of @SelinaTroester and the entire team of the #grebienlab! check 📰 and 🧵 👇
Super excited that the work from my PhD is out now in @NatureComms!🎉 We uncovered direct epigenetic and transcriptional targets of the NUP98::KDM5A fusion oncoprotein driving pediatric leukemia & identified CDK12 as a potential therapeutic target! #AML
https://t.co/xGs6YxZaTF 1/
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En route to Malaga for the @EHA_Hematology #ReCon2025. Excited to present recent work from the #grebienlab on targeting fusion oncoproteins in #AML 🇪🇸 🩸@VetmeduniVienna @StAnna_CCRI @CeMM_News
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Collaboration is key to scientific progress! @florian_grebien, PI at St. Anna CCRI, shares why interdisciplinary partnerships are important drivers of innovation and offers advice to young researchers who are just starting to build a network. >>> https://t.co/VV6rCwDUTM
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Abstract submission for the Molecular Hematopoiesis Workshop at @EHA_Hematology annual meeting in Milan is now open! Selected speakers get annual meeting registration; hotel accommodation; & travel reimbursement. More details and abstract submission here:
ehaweb.org
EHA is the leading force in hematology, bringing the community together to share knowledge, collaborate, connect, and grow. Join us now, and enter a world of Borderless Hematology.
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Join us at the 36th #GPOH #KindPhilipp2025 (June 4–7, 2025) in #Wilsede, Germany! Explore cutting-edge #PediatricOncology & #Hematology with top keynote spekeaker @SteidlUli, @ulrichschueller, @K_Imkeller and the Kind-Philipp-Presentation Award. Register: https://t.co/TKcM0LGidZ
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Thank you to our four international speakers—Paola Scaffidi, Alex Kentsis (@oleg8r), Judith Zaugg (@zauggj), and @iannisaifantis1—as well as our PIs, @PKameneva, and @gcresswell, for their thought-provoking and engaging presentations, as well as @MedUni_Wien for hosting us!
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Thanks to colleagues at @StAnna_CCRI for an exciting Epigenetics Symposium and inimitable Ball in Vienna
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In a couple of days at Van Swieten Saal in Vienna: join us for an immersive afternoon with six fantastic speakers and learn more about #pediatric #cancer & #epigenetics.
Join us at the St. Anna CCRI Symposium #CancerEpigenetics and explore groundbreaking research with top experts! Register now >>> https://t.co/ZMPsMUQkYJ 🗓 January 24, 2025, 14:00-17:30 📍 Van Swieten Saal, Medical University of Vienna
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New year - new goodbyes 👋 Thank you, @SelinaTroester for being a role model #PhDstudent for so many others in the #grebienlab over the years. You will be missed! @VetmeduniVienna @StAnna_CCRI @CeMM_News
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🚨Registration deadline for St. Anna CCRI #Cancer #Epigenetics Symposium this Sunday, January 12th! More Info and registration here >>> https://t.co/Vtg1PwwTeY Don’t miss this incredible opportunity—secure your spot now!
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📢Funded #PhDposition! – Pls RT! Looking for a passionate PhD student to explore cellular crosstalk in #TumorMicroenvironment combining #organoids #scRNAseq&high-res imaging. Join us @VetmeduniVienna in a vibrant research environment! #CancerResearch #PhD
https://t.co/47FKo7tkoX
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