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AJ Leonardi, MBBS, PhD Profile
AJ Leonardi, MBBS, PhD

@fitterhappierAJ

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Junior Physician-Scientist Views own

Joined November 2009
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
6 months
In 2020 I claimed covid infections and reinfections would cause T cell exhaustion and harm to T cells. Now, to my minimal surprise, the head of the american association of immunology has published the very hypothesis disparaged and called nonsense below; that covid harms the
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@VincentRK
Vincent Rajkumar
3 years
This is an immunology question. And their answer is correct: It is nonsense.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
4 hours
I admire your resolve in meaningless debates and wish you well with your quest for herd immunity with a pathogen that indeed harms the immune system.
@HelenFa92229708
Helen Farrell
22 hours
@oliver_phil @SalamonSMD @JPWeiland @MackayIM Sorry man. I thought the “Leonardi effect” stuff had been given a decent burial. Best wishes to you but I can see why Ian disengaged.
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@grok
Grok
4 days
Generate videos in just a few seconds. Try Grok Imagine, free for a limited time.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
7 hours
Hopefully advances in technology will reduce water consumption. I think this is a critical area of R and D.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
7 hours
A situation where AI, even if just a tool, competes for resources with life (fresh water) is the worst case scenario. At what point will a prompt be worth more to fulfill than the life of a living organism? The cost of both will be weighed against each other. Dystopian.
@unusual_whales
unusual_whales
3 days
Texas data centers are projected to use 49 billion gallons of water this year, as the state faces a prolonged drought, per MorePerfectUnion.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 days
Oof. Farid believed it was megakaryocyte precursors. What cells?.
@AlbaDocherty
Alba ࿐ ITEOTWAWKI
3 days
"We are seeing true nucleic acid persistence in bone marrow cells in some of our patients with Long Covid.". -Timothy J. Henrich, MD.Keystone Symposia on Long Covid 2025.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 days
RT @_VFK_DAA: 1) Study finds healthy lab-grown muscle exposed to ME/CFS or Long COVID blood quickly loses strength, temporarily boosts meta….
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 days
RT @JackHadfield14: 🔬New @BhupeshPrusty paper breakdown - very cool paper:. The study finds that people with ME/CFS & Long COVID have antib….
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
12 days
In 2020-2023 when I was still a med student, several pompous professors and senior academics chose to epistemologically trespass on the topic of immune harm from covid and punch down, mocking my experience and expertise. I wonder if they believed it or if they intentionally lied
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@mryoung151
Martha-JD, MBA, PCC-😷
13 days
City Doctors Blame ‘Long Covid’ For Severe Viral Infections That Have Laid Kolkata Low. A past history of ‘long or severe' Covid may have led to long-term weakening of respiratory and immune functions, making thousands in the city more vulnerable to recurrent infections, say
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
15 days
This is an example of the limited scientific imagination my detractors seem to have, hiding behind an anonymous account. They don't understand that I saw, based on immunological published phenotypes, clear evidence that covid (a respiratory virus) was harming T cells, and warned.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
15 days
Imagine epistemologically trespassing just to be wrong but being too arrogant to tell like Zeynep and Mark. Imagine commenting on something in your field and being wrong like Marc Veldhoen, Jeremy Kamil, and Antonio.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
15 days
In 2020 and since then, I was eviscerated by many "cautious" professors and scientists for saying Covid harmed the cells responsible for controlling cancers and infections. Marc Veldhoen and Antonio Bertoletti went as far as to call T cells "fit and happy" after covid infection
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@EricTopol
Eric Topol
16 days
We've known that Covid increases the risk in survivors of cancer, but today @Nature a mechanism of reactivation of cancer cells elucidated in the experimental model.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
19 days
I hypothesized and discovered the differentiation of T cells via Fas, which was viewed as a canonical death protein only. It works on cd4s and cd8s and I encourage anyone curious to try it.
@TheMemeticist
Ξpi-Yeti
19 days
@fitterhappierAJ They basically brushed you off as a rando, even though you're far more qualified to actually have an opinion on the matter than Zeynep.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
19 days
Back in 2020 I gave the same warning and carried the same concern that covid was like a cancer. For this claim, many virologists and nay-sayers came out of the woodwork to disparage and slander me because of their lack of scientific imagination and professional contempt, like
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@newstart_2024
Camus
25 days
Dr. Patrick Soon-Shiong Issues Urgent Warning: COVID-19 is Not Just a Respiratory Virus—It’s Like cancer. "This virus has beaten us.". In a chilling revelation, Dr. Patrick Soon-Shiong—renowned surgeon, scientist, and billionaire biotech pioneer—warns that COVID-19 is far more
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
1 month
Holoendemicity creates earlier death than hyperendemicity for all groups due to constant inflammation. When we learned to live with covid we learned to die from its inflammaging.
@TheRustler83
Rustler
1 month
@ONS 10,075 deaths in week 26 of 2025. 8,979 deaths in week 26 of 2020. Why are we seeing 1,096 MORE deaths in 2025 than we were during a ‘PANDEMIC’ even in 2020????
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
2 months
RT @RepJoeNeguse: BREAKING — Senator Lee has just withdrawn his public lands sell-off provision! . Thanks to your efforts, the American peo….
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
2 months
Why did people like Zeynep claim that mecfs and long covid were the same?.
@vipintukur
Vipin M. Vashishtha
2 months
A NEW study reports that a high school student worked w/ researcher of University of Victoria to develop #Mobius, a transformer-based AI model that used blood DNA methylation data from 852 individuals to distinguish ME/CFS, LongCOVID, & healthy controls with 97% accuracy. 1/
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
2 months
RT @DrPatSoonShiong: I wil draft an X article today to discuss this finding that every 10 percent drop in NK and T cells results in 48 perc….
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AJ Leonardi, MBBS, PhD
3 months
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 months
RT @maolesen: Here's really strong evidence of immune damage from COVID among bacterial infections with no vaccines. Look at the sharp clim….
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 months
Older generations default to believing video images. New generations will default to their disbelief.
@abby4thepeople
abby
3 months
A judge is heavily fining a law firm that cited cases that were completely made up by AI. He says that he almost used the case law to write his ruling but luckily decided to check the citations. We are one lazy judge away from having case law that was made up by chatgpt.
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@fitterhappierAJ
AJ Leonardi, MBBS, PhD
3 months
RT @MeetJess: British Airways plane caught fire after pilot mixed up left and right during take-off . Closing Gatwick airport and causing d….
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dailymail.co.uk
The jet had been about to take off from Gatwick to Vancouver when the co-pilot mistook his right hand for his left and pulled back on the lever operating the aircraft's thrust.
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