Patient with Hodgkin Lymphoma post first cycle of chemotherapy presents with these rashes and peripheral eosinophilia.
What's your diagnosis
#medtwitter
?
#hemeonc
NOTHING can make a doctor’s day brighter than sending their patient with leukemia , CANCER FREE home . One such day for us, Dr Aishwarya , Dr Harshal ,me and Dr Souvik are all smiles 😀
PS : picture taken with consent from parents
#leukemia
#hematology
#MedTwitter
#mrdnegative
⚡⚡How to manage anticoagulation in thrombocytopenic patients with cancer?
👉platelets>50000: full dose anticoagulation
👉25-50k: full dose anticoagulation with platelet support or half dose anticoagulation
👉<25000: hold ✋anticoagulation
#medtwitter
#vte
#cancer
#hemeonc
#MedTwitter
#hemeonc
@MedTweetorials
⚡️ Bleomycin Induced Flagellate Dermatitis
⚡️ can occur with any dose/any route of bleomycin
⚡️ bendamustine too can cause this erythema
⚡️ rx: stop bleomycin
⚡️ corticosteroids/antihistamine are adjuncts
⚡️22% has peripheral eosinophilia
📌The current classification and prognostication of AML demands cytogenetics & molecular genetics (WHO/ICC &ELN) and has resulted in incorporating ideal therapy and targeted agents and hence improved outcome in this aggressive disease.
🙃But it is not always that when a patient
I wish my favorite Prof of hematopathology Sumeet Gujral Sir was on twitter
He is so full of positive vibes and happiness and knowledge
#HCC2022
#medtwitter
Hematology is deeply humbling 💛💛,
Mind boggling 🤯
📌Just saw a lady in her 30's with bilateral deep venous thrombosis with history of easy bruising since birth and now diagnosed with Glanzmann thrombasthenia ❗🤷♀️🤷♀️
#MedTwitter
Silvery hair syndrome is a rare syndrome and includes Griscelli syndrome ,Chediak-Higashi syndrome and Elejalde disease.
Here is one case of Griscelli syndrome we encountered, thanks to Indian society of dermatopathologists.
#dermpath
#pathologists
#Pathology
@pembeoltulu
It is important to differentiate between type 1 and 2 of endometrial carcinoma, as they have different prognostic and therapeutic implications.
#gynpath
#oncopath
#pathology
The morphological clues to CLL includes the classic chromatin of the cells which has been compared to
📍cracked mud,
📍 football
📍Ausage and pepperoni etc
Other features are of course smudge cells or Gumprecht shadows.. here is a nice picture of the classic chromatin in CLL.
@OGdukeneurosurg
Primary care physician with his steth , oncologist in the middle with her colored pens so highlight important precautions with chemo and the neurosurgeon in jeans who had used a note pad with painting to assess motor cortical function 😃
Burkitt's lymphoma
Did u know that EBV and Plasmodium falciparum interaction is thought to be responsible for endemic Burkitt lymphoma supporting the the emerging concepts of "POLYMICROBIAL DISEASE PATHOGENESIS"?
#hemepath
#pathboards
A case shared by
@DrGeeONE
.
@pembeoltulu
Some more
#hemepath
non corona academics today
#NCA
Whenever going through morphology of megs, i always tend to get confused.. so here is an infographic of the various morphology of this beautiful cell in various myeloid neoplasms
#leusm
#MPN
#hemeonc
#hematology
Today was a happy day
@SGPGI
We just got 3 brand new certified hematologists + it was a pleasure to interact with two senior lady hematologists as our externals, Prof Tulika ma'am and Prof Maithrayee ma'am 😊
#womeninhematology
Congrats to all 3,
@nihardesai7
@gopinathan
@archit
Histoplasmosis.
Numerous tiny intracellular uninucleate yeast like forms within histiocytes.
Not much of neutrophils or eosinophils.
This case was a skin nodule in a farmer.
#dermpath
#Pathology
#Pathologists
@pembeoltulu
📌Differences in anti CD 20 monoclonal antibodies.
👉Rituximab is a chimeric mAb that is partially humanized with🐀 variable region
👉 Both ofatumumab and obinutuzumab are fully humanized mAbs🧍♂️🧍♀️
👉 Ofatumumab also has a glycoengineered Fc ➡️better binding with immune effector
DIAGNOSING POLYCYTHEMIA VERA 🩸
📌Is bone marrow biopsy always necessary ?
🎯Not necessary in JAK2 exon 12 or 14 mutated patients if Hb > 18.5g/dl in ♂️or >16.5 g/dL in ♀️ as per ICC and subnormal EPO.
✌️Ofcourse a baseline Bone marrow biopsy always is helpful to identify
🚩mini
#tweetorial
on Ph like ALL
1⃣/8⃣
⚡️“Ph-like”or BCR-ABL1-like ALL was described by the COG& Dutch COG by GEP in 2009
⚡️Adopted in 2016 update of WHO as provisional entity
⚡️lacks the BCR-ABL1 translocation but similar gene expression as Ph+B ALL
#medtwitter
#hemonc
#leusm
Eid Mubarak from our family to yours to my twitter fam 😊
May the Almighty bless us all with his choicest blessings, the gift of kindness, happiness, peace and love.
#️⃣COVID-19 AND COAGULOPATHY
▶️ Increased D -DIMER.
▶️MODEST DECREASE IN PLATELET COUNT.
▶️PROLONGED PT
▶️FIBRINOGEN IN THE UPPER LIMIT OF NORMAL AS ACUTE PHASE RESPONSE.
▶️ ⬇️IN FIBRINOGEN SEEN SHORTLY BEFORE DEATH
⚡DO HOW IS IT DIFFERENT FROM DIC OF SEPSIS❓❓READ ON
👉The journey of clonal plasma cells in a video
#mmsm
#leusm
#myeloma
#MedTwitter
1. Primary genetic events ie Ig H translocation/hyperdiploidy ⏭️ initiation of clonal plasma cells in post germinal centre B cells
2.MGUS
3. Smoldering myeloma
4. 🔥 ie Myeloma with CRAB features
📌Chemotherapy Induced Thrombocytopenia(CIT)🧵 ▶️Platelets< 100x10^9 in patients receiving chemotherapy
▶️MC reason of thrombocytopenia in cancer patients ▶️Mechanism: Drug induced myelosuppression/cytotoxicity
▶️Leads to Reduced Dose Intensity⏭️poor outcome
#MedTwitter
#hemeonc
What has changed in the management of the most common Lymphoma in the world ?
Catch me live discussing the recent advances in the diagnosis and management of DLBCL
#MedTwitter
#bloodcancer
#cancer
#hematology
#HEMATOLOGYFACTS
⚡Auer &Mc Crae described Auer rods at the same time& that we dont giv McCrae due credit?
⚡Also both presumed Auer rods R seen in lymphoblasts?
⚡Though virtually pathognomonic of AML, it can also be seen in MDS-EB/ CMML2
#hematology
#hemepath
#hemeonc
#MedEd
Recently one of my papers got rejected! Disappointed, I was googling& stumbled on to this
@bmj
Had my share of laughter and sharing for my favourite twitterati
Rejection of the rejection letter..😉..
Hope u smile amidst all the stress we r in
#MedTwitter
#medjokes
@nihardesai7
📌Therapy in CML has come a long way from Imatinib that made to the cover of the TIME MAGAZINE.
Let us say hi to the two new 3rd generation Tyrosine Kinase Inhibitors💊💊
1 👉OLVEREMBATINIB and
2 👉VODABATINIB
#CML
#TKI
#MedTwitter
@MedTweetorials
⚡️limiting VEN exposure to the concurrent days of AZA (7+7 ) had similar response rates like ven for 28d.
⚡️with this 7+7 scheme&ven at 50mg with posa is going to reduce the costs immensely in India with generics for posa and ven😊
#hemeonc
#medtwitter
Approach to hepatic masses.
#GIPath
Vyas M, Jain D.
A practical diagnostic approach to hepatic
m a s s e s . I n d i a n J P a t h o l M i c r o b i o l
2018;61:2-17
Bizarre leiomyomas are so called because of the "bizarre" cells.
So how to differentiate it from leiomyosarcomas?
Here are a few helpful tips.
#gynpath
#pathology
#pathoaddict
#imagesinhematology
Sharing an interesting case.
⚡13yr old male child with history of seizure disorder presented with fever& peripheral smear (shown below in a speacial stain)90% blasts
#MedTwitter
❓ syndrome?
❓Mutation
❓What is the probable type of acute leukemia?
#leusm
⚡Mechanism of action of hydroxyurea in sickle cell disease
⚡Not only is HU is an Hb F inducer, but it also has vascular effects like ⏬endothelial activation and⏬ vasoconstriction and ⏬thrombosis .
Cheapest yet most effective drug in sickle cell disease
#SCD
#Medtwitter
As everyone rightly said, this was a case of tuberculous ulcer, the most common cause of granulomas in India.
Large confluent granulomas, necrosis,lymphoid cuff,granulomas below the mucosa and submucosal inflammation are few pointers of tubercular etiology.