Dan Zhou
@zdangm
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Joined October 2017
The China Brain Multi-omics Atlas Project (CBMAP) https://t.co/E2dUveV2OV
#biorxiv_neursci
biorxiv.org
The China Brain Multi-omics Atlas Project (CBMAP) aims to generate a comprehensive molecular reference map of over 1,000 human brains (Phase I), spanning a broad age range and multiple regions in...
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gsMap paper online. Source code: https://t.co/J1YnfnJ1j6. Results visualisation website: https://t.co/mVKmv21wbZ.
Nature research paper: Spatially resolved mapping of cells associated with human complex traits https://t.co/0d0HWN7KpY
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Genetic mapping of serum metabolome to chronic diseases among Han Chinese
cell.com
Cheng et al. present a landscape of the genetic regulation of 2,759 serum metabolites in four cohorts among Han Chinese individuals, offering valuable insights into the role of serum metabolites in...
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📢New from Bledsoe & @egamazon! 📰A transcriptomic atlas of the human brain reveals genetically determined aspects of neuropsychiatric health https://t.co/BiKe4ZWXTz
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Links to the recordings: Day 1: https://t.co/aQVjDIAqNK
https://t.co/feFIb5c2GI Day 2: https://t.co/oUs6natDGg
https://t.co/S7IzT3fguZ
Enjoying re-watching Day 1 of this NHGRI meeting on genetic architecture [ https://t.co/ecVfVUO7HM]. My notes below, with comments in [].
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I'm delighted to release the first half of my new open-access online textbook in human population genetics: https://t.co/GHMPCTv6BL
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Sooo happy to hear that!!
Congratulations to @NancyGenetics, director of the @VUMCgenetics, for receiving the 2023 ASHG Leadership Award from the American Society of Human Genetics (@GeneticsSociety). https://t.co/4LVfOSI5YH
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GxE PRS: Genotype-environment interaction in polygenic risk score models for quantitative and binary traits
biorxiv.org
The use of polygenic risk score (PRS) models has transformed the field of genetics by enabling the prediction of complex traits and diseases based on an individual’s genetic profile. However, the...
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Excited to share our work, just out & featured in @NatMachIntell We develop a ML approach for gene expression imputation across cell types/tissues. With Ramon @bidumit @pl219_Cambridge @chaitjo @DobrikG Phillip @VUMCgenetics @Cambridge_CL @cancer_dynamics
https://t.co/gO4VfnZI8z
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Thrilled to share our latest work! We have generalized the SMR&HEIDI approach to a multi-omics model, which links ~50% GWAS loci to 7 types of molecular phenotypes genetically. https://t.co/gUsH58s0tP
cell.com
Wu and colleagues developed OPERA, a method that integrates genetic analysis of multi-omics data with GWASs to explore the biology of genetic associations. They found that 50% of GWAS signals are...
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My commentary article @Nature, a lot more work to do in the field the Chinese microbiome research in future. Mapping the Chinese microbiome: it’s time for a united effort
nature.com
Nature - Much has been done to investigate the human microbiome. Now, it’s time for countries to dig deeper.
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fastGWA-GE: an extension of fastGWA to test for GxE. Also part of GCTA now contributed by Wujuan Zhong and Judong Shen from Merck Research Laboratories.
academic.oup.com
Abstract. Genotype-by-environment interaction (GEI or GxE) plays an important role in understanding complex human traits. However, it is usually challengin
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I'm very pleasured to announce the publication of our TOP-LD: https://t.co/as0Rf5gcNb. A handy and fast query to search LD information across multiple populations using TOPMed WGS data: https://t.co/cmPOlIXHQR Great collaboration with @AuerPL
cell.com
Current publicly available tools that allow rapid exploration of linkage disequilibrium (LD) between markers (e.g., HaploReg and LDlink) are based on whole-genome sequence (WGS) data from 2,504...
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Check out our press release for the new article in npj Genomic Medicine featuring @zdangm and @egamazon. Cool new methodology and a really neat application. Did you know COVID-19 severity is linked to Neanderthal DNA? Check out the story here: https://t.co/Y2y86PpxAa
#Evolution
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Many many thanks to Eric, the group, and the VGI! Will keep working with them on a lot of shared interests!
Delighted to share our latest @Nature_NPJ on estimating expression-mediated heritability due to a genomic segment (eg regulatory element, stretch of DNA under positive selection, or introgressed haplotype) with @zdangm @VUMCgenetics Software available.
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