I'm really excited to introduce our new paper @DulacLab on the neurobiological original of "sociality" (the need of being together), recently published in Nature (see detailed digest below).

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RT @HaoSheng265720: 🎉 Excited to share that my PhD work is now published in Nature!.We used embryonic development to implant ultrasoft elec….

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RT @MCB_Harvard: Dulac Lab Identifies “Loneliness” Neurons in the Hypothalamus @DulacLab @dingliuabc @Harvard @harvardbrainsci @MMostafiz….

And the colleagues from the Dulac lab: @ Mostafizur Rahman, @ Autumn Johnson, @ Zuri Sullivan, @ Nicolai Pena, @ Mustafa Talay, @ Brandon Logeman, @ Samantha Finkbeiner, @ Lechen Qian, @ Athena Capo-Battaglia.

Thank all the collaborators and lab members for their contribution and superb teamwork:.@naoshigeuchida, @ Mitsuko Watabe-Uchida, @ Ryunosuke Amo, @ Iku Tsutsui-Kimura, @ David Ginty,.@SSebastianChoi, @IshmailSaboor.

We also found that touch is a key sensory modality for mice to perceive social environment, with lack of touch sensation leading to the emergence of social need, and its presence providing social satiety.

Projections from Isolation neurons to oxytocin neurons, lateral habenula and arcuate nucleus mediate social drive, aversion and inhibition of eating, respectively. Projections from Reunion neurons to VTA lead to dopamine release during reunion.

We further identified two molecularly defined interconnected neuronal populations in the hypothalamus, one activated by social isolation, the other by social reunion, together mediating a dynamic balance between “social need” and “social satiety” states.

First, we characterized a "social rebound" behavior triggered by social isolation, which suggests a homeostatic regulation of social need. Intriguingly, different mouse strains showed distinct social rebound intensity after isolation, indicating a genetic basis for social need.

RT @takaki_komiyama: 663 days since the senseless tragedy that took An, we present a manuscript that reports some of the discoveries that s….

RT @LiPingWangION: It’s time to work WITH memory!.New work from our lab is out: Extra temporary subspace is necessary for information excha….

RT @neuronair: Beyond grateful to share two co-first author papers that came out in @Nature!! With @AmitVinograd, we provide causal evidenc….

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RT @LChittka: Our new paper is out today in @Nature , showing that bumblebees possess the cognitive capacity for some of the key ingredient….

RT @ardemp: I wrote down my rules on how to Science. I hope you find it useful!

RT @MengyuLiu96: Linlin will be a fantastic PI!.