David A Knowles (@davidaknowles.bsky.social)
@david_a_knowles
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machine learning and functional genomics at @Columbia and @nygenome. he/him/his. @[email protected] @davidaknowles.bsky.social
New York, NY
Joined August 2015
Free in-person registration is open for #MLCB2025! Sept 10-11 at @nygenome and online at Paper/abstract deadline is June 1, more deets including our fantastic invited speaker lineup at Please RP.
mlcb.org
The 20th Machine Learning in Computational Biology (MLCB) meeting will be a two-day hybrid conference, September 10-11, 9am-5pm ET, with the in-person component at the New York Genome Center, NYC....
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RT @AJHGNews: 📣New from @david_a_knowles & co!.📄Leveraging functional annotations to map rare variants associated with #Alzheimer disease w….
cell.com
This study introduces genome-wide rare variant enrichment evaluation (gruyere), a Bayesian framework for rare variant association studies that improves variant prioritization by learning a trait-sp...
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Blazing-fast image creation – using just your voice. Try Grok Imagine.
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RT @SuryaGanguli: *Every single* cure for a disease ultimately flowed from basic exploratory research. Stopping basic research is like sto….
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RT @sebatlab: explainer for the tech bros. 60% is added on top of direct cost (and equipment are not included). So for every dollar that go….
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RT @sebatlab: Your math is wrong dude. Let me get this straight. All this time you thought a that an indirect cost rate of 60% meant that U….
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RT @nmancuso_: Ok that's it I'm done here. I'll leave this account up to avoid it being eventually commandeered. but will not be posting/in….
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There are 10 days left to submit abstracts to ProbGen Fantastic line-up of speakers and topics.
meetings.cshl.edu
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
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Please could some @PyroAi folks (@ftzo @Tkaraletsos @nmancuso_) give me some insight on what I'm doing wrong here?
forum.pyro.ai
Hi all. I have a model which is a hierarchy of GLMs where I want to test a null vs full model for each sub-GLM (there are params shared between these GLMs in the real version although not in the MWE...
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Our first foray into (noncoding) rare variant association testing! gruyere learns functional annotation importance & finds associations missed by existing methods. @_anjalidas did a fantastic job with model assessment & scaling! Joint w @towfiqueRaj
medrxiv.org
The increasing availability of whole-genome sequencing (WGS) has begun to elucidate the contribution of rare variants (RVs), both coding and non-coding, to complex disease. Multiple RV association...
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RT @david_a_knowles: The fantastic Machine Learning in CompBio #MLCB2024 papers are up at (thanks @lawrennd !) Remi….
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The fantastic #MLCB2024 talks, spotlights, panel & keynotes are now up on our Youtube channel at Please RT!.
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RT @compbiologist: Two @TroyanskayaLab alums — @zhou_jian & @ChikinaLab — giving keynotes at #MLCB2024!. Jian now talking about sequence ba….
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#MLCB2024 kicks off in 22h (9am PST) with keynote from @zhou_jian on DL for transcriptional initiation! Full schedule at and public livestream at Please RT!.
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RT @jmschreiber91: Looking forward to #MLCB2024 later this week! Really happy to see the wide variety of work being done. Sometimes, in the….
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RT @sara_mostafavi: #MLCB2024 will be streamed live from YouTube this week (Thursday and Friday). Get the link from here: .
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RT @HannahPaynePhD: 📢I am elated to share that I will join the Center for Neural Science & Dept. of Psychology at NYU as an Assistant Profe….
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