Dan Okin
@danokin
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Physician Scientist @HarvardPulm @MGHmedicine | Post-doc in @jkagan1 lab | @RMedzhitov alum | Immunology and evolutionary biology
Boston, MA
Joined March 2007
👇🏻👇🏻👇🏻Check out this great study on oxidized lipids and how they control inflammation!! Congrats @Lo_Zanzi !.
#EpigeneticPower! Our #NewPaper @ImmunityCP shows that endogenous oxidized lipids decide whether host survives or dies during #sepsis, #ARDS, or Staph infection! Ox lipids bind & inhibit #AKT, boosting inhibitory H3K27 methylation via EZH2, blocking #IL10!
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Congrats @XuZhouLab on a fantastic study, excited to see where you take this next!.
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH
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RT @NatRevImmunol: BRD4 acts as a pH sensor to tune inflammation
nature.com
Nature Reviews Immunology - A preprint by Wu et al. identifies BRD4 as a sensor of pH, with notable implications for the regulation of inflammatory genes.
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RT @Anh_Immunology: Finally, our study on caspase-11 and its CARD-recognized molecular pattern is out in Science Advances! A small step, bu….
science.org
A bacterial sensory protein detects self- and nonself-lipids by similar mechanisms.
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Congrats on the great story @JelenaLab!!.
The loss of TBK1, or both TBK1 and the related kinase IKKε, results in uncontrolled cell death–driven inflammation. We show that TBK1/IKKε prevent premature cell death by limiting the activity of multiple death pathways in myeloid cells.@FabiAlexFischer
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RT @ItaiYanai: We have to stand up for science! Anyone who can join these rallies and believes that US science must be protected should com….
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RT @VitalikButerin: The more I think about it, the more I think 2013-era morality is pretty much correct:. * free speech good.* starting co….
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RT @darbysaxbe: I need people to understand how difficult it is to get an NIH grant. You spend months writing a proposal, following strict….
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RT @DanaFarberNews: In a study published in @SciImmunology, led by @Dr_KatieM, @DanaFarber researchers have identified key factors that con….
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Wonderful piece @vcunningham and congrats on the new kid! Merry Christmas! 🎄.
i wrote an essay for Christmas. it's about darkness and light, high peaks and low depths, the crooked and the straight—a year of surprises. a little token to stuff your stocking. link's in the next tweet.
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RT @gheimberg: 1/ Introducing SCimilarity, a new foundation model to explore scRNAseq data across tissues and diseases! It learns a common….
nature.com
Nature - In a 23.4-million-cell atlas of 412 single-cell RNA-sequencing studies, SCimilarity query of macrophage and fibroblast profiles from interstitial lung disease reveals similar cell profiles...
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RT @globalimmuno: The recorded video of Dr. Jon Kagan seminar entitled Regulation of Innate Immunity is now available at “Global Immunotalk….
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RT @Lo_Zanzi: #EveryCellIsAnImmuneCell!💥Thrilled💥for our new paper @CellCellPress with @achillebro! We show that, during #IBD, type III #in….
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RT @IshanDeshpande: Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvis….
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RT @FitzgeraldKate: Looking for an up to date review on dna sensors and their role in autoinflammatory diseases check out this review from….
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RT @The_PW_Lab: 🚨Vanderbilt is hiring🚨 Join an incredible community of motivated, creative, supportive scientists (in a super fun city in a….
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RT @HelenBranswell: US government is going to again make #Covid tests available for free, starting in late September. Folks will be able to….
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RT @PennMicro: 🔬Mark your calendars! .The Microbiology Seminar Series returns on Wednesday, Sept. 11th. Please join us for a seminar with D….
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