Ishan Deshpande
@IshanDeshpande
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Structural biologist & biochemist fascinated by membrane proteins. Principal Scientist at @genentech.
San Francisco, CA
Joined February 2018
We are hiring a postdoc! Fantastic opportunity for a stuctural biologist to tackle important mechanistic questions in inflammatory signaling. Please RT/apply.
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An excellent summary by @EBernard1993 and @broz_lab , contextualizing our recent work.
How is the protein NINJ1 regulated so that cells break open only when they die?
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Obviously, we wont survive with NINJ1 constantly poking holes in our cells. So how is NINJ1 kept on a leash? The answer turned out to be quite simple. NINJ1 autoinhibits in trans by forming a face-to-face dimer. This shields its hydrophilic face (resembling a partner dance) (3/3)
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NINJ1, a tiny membrane protein, ruptures the plasma membrane to amplify the immune response during lytic cell death. Previous papers showed active NINJ1 forms filaments (resembling a river dance) and NINJ1 filaments rupture membranes via an exposed hydrophilic face (2/3).
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Thrilled to share our findings on NINJ1 autoinhibition, now online in @Nature. Big thanks to the amazing team @dixitvishva @Melissa_Truong @DrMCJohnson @AlexisRohou and many others. Video by the talented, twitterless Sergei Pourmal (1/3)
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I'm #hiring a Scientist to solve molecular mysteries in cell death and inflammation at @genentech. Best suited for talented protein biochemists interested in #cryoEM. Please RT! .Apply here:.
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Great opportunity to do impactful work with the amazing @AashishManglik and his team (from personal experience).
We are looking for a research specialist/lab manager at all levels to join our lab! Come learn about signaling, structural biology, and protein engineering. Please RT.
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RT @AashishManglik: We are recruiting for a lab manager/research technician in the Manglik lab! Come join our awesome team interested in GP….
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RT @Myers_lab: We're hiring a lab tech! Great opportunity to study development, cancer, GPCRs, kinases, or all of the above. We have a fant….
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RT @StanfordLPA: Adriana Gonzalez (@AV_GonzalezS) works at @StanfordPeds where she uses her PhD background on epigenetics to explore its ro….
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RT @AashishManglik: @deboramarks A fun collaboration! Our nanobody consortium with #kruselab @deboramarks @aaronmring and @chang_c_liu is r….
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Great work by an amazing team led by @AashishManglik, Peter Walter and Michael Schoof. Looking forward to a favorable outcome in clinical trials.
We're excited to share a preprint from an incredible collaboration between our group, Peter Walter’s lab, the @QBI_UCSF Structural Biology Consortium, @VignuzziLab, and many others to discover potent nanobodies that neutralize #SARSCoV2 infection. 1/15.
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RT @Myers_lab: With great excitement, we present our latest study, focusing on a key question in Hedgehog signaling: how the GPCR Smoothene….
biorxiv.org
The Hedgehog (Hh) pathway is essential for organ development, homeostasis, and regeneration. Dysfunction of this cascade drives several cancers. To control expression of pathway target genes, the G...
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RT @AV_GonzalezS: Super excited, I am a semifinalist in the Biorender contest!!. If you like my Graphical Abstract….
app.biorender.com
BioRender is an online tool for creating beautiful, professional science figures in minutes.
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RT @mbeisen: First 100 signatures on our open letter in support of Zero Embargo #openaccess - only 331,002,551 to go by midnight!! #OAinThe….
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RT @UCSF: How did an epidemic of one-eyed sheep lead to a new avenue to attack cancer? UCSF postdoc @IshanDeshpande explains in less than 3….
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